Agetron
#738
Hey Erik…sounds like you have a solid plan… I understand micro-dosing to keep a constant level.
Personally, I hate shots… lol.
So once a week injection works for me.
After 6 years… no real extremes highs or lows… I will stay the course. Appreciate the inquiry.
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Ulf
#739
A biceps muscle injury that had persisted for six months was resolved with TB-500. I injected straight into the muscle around 20 times.
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Was that tb500 or tb4? At least in the grey world, it is a consensus that all TB-500 is really tb4
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Excellent, I stand corrected then . Thanks for the clarification , @Steve_Combi!
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Davin8r
#743
TB 4 is the full, naturally-occuring 43 amino acid molecule and is almost always what is currently (and incorrectly) marketed as “TB-500”. Actual TB 500 is the 17-23 frag and is very rare.
Ulf
#744
I believe TB-500 is superior to thymosin beta 4 for wound healing.
From perplexity.ai
TB-500 is a synthetic derivative of thymosin beta-4, a naturally occurring peptide found in human and animal cells. While thymosin beta-4 is a 43-amino-acid protein encoded by the TMSB4X gene, TB-500 is a smaller peptide fragment derived from it, specifically containing the actin-binding motif (LKKTETQ). This motif allows TB-500 to replicate many of thymosin beta-4’s functions, such as promoting cell proliferation, differentiation, and migration, which are critical for wound healing and tissue repair123.
The primary difference lies in their origin and scope of activity. Thymosin beta-4 is naturally produced by the body and has broader biological effects, while TB-500 is synthetically designed for targeted applications like enhancing healing and reducing inflammation. Both peptides share similar mechanisms, such as regulating actin polymerization and promoting angiogenesis, but thymosin beta-4 has a wider range of functions beyond those of TB-50023.
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The GLP-1 -secreting L cell is an inflammation sensor and once again GLP-1 levels correlate with the severity of acute illness, here respiratory failure.
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Bruce
#746
Tim, if you get some lidocaine to inject near and around the bunion you can eventually get it fully numb.
I treated my wife.
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Palatin Announces MC4R Agonist Bremelanotide Co-Administered with GLP-1/GIP Tirzepatide Meets Primary Endpoint in Phase 2 Obesity Study?
FYI, bremelanotide is pt-141. They used a low dose of that along with tirzepatide (2.5 mg) which resulted in additional weight loss vs tirzepatide alone.
40% of combination patients achieved ≥5% weight loss versus 27% on tirzepatide alone (p<0.05) indicates a substantive therapeutic benefit.
They also claim that pt-141 stops the rapid weight regain from halting tirzepatide.
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Davin8r
#748
Also makes you nauseous and horny! It wouldn’t be my first choice of meds to combine with tirz, but I guess more options aren’t a bad thing.
Bremalanotide/PT-141 also requires a once daily injection since half life is short, so this doesn’t seem like much of a practical solution for the average person.
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Yep, that’s I what I thought was so funny about this stack. It’s used to raise libido.
I think.ñ pt-14 was in pill form in the study, so it will just be a daily pill that people take.
Davin8r
#750
There’s no oral version of bremelanotide/PT-141. It’s a daily injection:
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Thanks for the correction! I could have sworn it was a pill. Wishful thinking…
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Why halt tirzepatide and then start another peptide just to get the same effect?
I assume to show that it is effective against weight regain induced by stopping tirzepatide.
Pt-141 is cheaper than tirzepatide, so if you can maintain most of your ideal weight while not having to pay for tirzepatide, you save money.
Early on peptide path, I “micro-dosed” PT141 in combination with our night time combo of Ipa+CJC did that for a couple months. That is a 5 night a week shot. We did that at bedtime and slept through the “side effects” that might be derived from PT141.
My interest in that little experiment was dopamine related.
It seemed to work but I may have had the dose a bit high for my intended purpose. It was 120mcg per dose. I think I’ll revisit that and use a 60mcg dose added to our nightly shot.
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I looked back through my email with my supplier on this. I had asked for TB500 and the first question was, which “version” (there are 3 versions of TB500), I decided on the frag 1-4 version.
The real name is not TB500 it’s…
Goralatide, cas# 127103-11-1
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Tim
#756
I have it in vials of lyophilized powder, which I converted to an intranasal spray. The effects, including the side-effects, are increased.
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Good to know! I didn’t realize there could be differences between delivery methods. One person told me that selank subq didn’t work for them, but was so much more effective in a spray. Just interesting.
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