Unless the active ingredients are not distributed evenly. Also enteric coating is not the only kind of coating. What of coatings that are put on in order to prevent oxygen or moisture penetration - if you split those, and leave one half for another day, you may be exposing the left over part to moisture and/or air, which may not be desirable; undesirable chemical reactions might take place. There might be coatings that are designed to expose the contents of the pill to the stomach and not anywhere else, so exposing part of the surface to saliva might also not be optimal. There are so many possibilities, that unless I know for sure, I donât just assume pill splitting is always safe.
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AnUser
#82
If they werenât the variation between whole pills couldâve been quite significant.
In addition to the examples @CronosTempi listed, thereâs also extended-release tablets, whose properties could be buggered by splitting; tablets with coatings designed to protect the throat from highly acidic or caustic contents; and nanocrystalline formulations, like the one used in Pfizerâs Rapamune.
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Now I made similar expirience with Brillo EZâŠ
I took half of a Nexlizet tablet (90 mg bempedoic acid + 5 mg ezetimibe) for two months, and it had a measurable impact on my LDL levels (they went from 98 to 66). However, after switching to the same dose of Brillo EZ from Jagdish (splitted tablet), my LDL went back up to 86.
Has anyone else had a similar experience with Brillo EZ? Could this be a matter of splitting, quality, or individual dynamic?
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I used to take 2/4 mg of Pitavastatin along with1/2 Brillo EZ. Changed Pitavastatin to atorvastatin 20 mg with the same 1/2 Brillo EZ. Also added a low dose 45 mg of Fenofibrate. Latest LDL 27, APO b 38. Very pleased. Will repeat in another three months to see if it continues.
Cheers, Mantheunknown
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Davin8r
#86
Yes, I also seemingly have had no significant effect of Brillo EZ from the same source (Jagdish), certainly not the crushing of LDL that I expected since I also take Repatha and eat a low sat fat diet. In my case, though, I never tried the branded version since itâs so expensive and my insurance wonât cover it. Your experience makes me even more suspicious that this product is garbage.
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Iâve seen great results from a full tablet of Brillo EZ from Jagdish. My LDL went from 122 to 68. My father had similar results.
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This could easily be an issue of some medication stored in poor conditions (e.g. very hot) somewhere in the supply chain, while another batch of medications not stored in suboptimal conditions.
This is perhaps one of the biggest risks with purchasing from Indian pharmacies; the opacity of the supply chain and storage conditions since manufacture.
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PBJ
#89
I agree, and the best time to order is now.
Nexlizet (bempedoic acid 90 mg + ezetimibe 5 mg) can be affected by improper storage, including warm temperatures. The manufacturer recommends storing Nexlizet at room temperature (68°F to 77°F or 20°C to 25°C), with permissible short-term excursions between 59°F to 86°F (15°C to 30°C).
Ezetimibe is known to be sensitive to heat and humidity, potentially leading to a loss of effectiveness.
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@PBJ , I am storing it in the fridge by +4 - that should be okay, here are âconditions for safe storage, including any incompatibilitiesâ â ezetimibe
bempedoic acid:
Until now, I have had two batches of Brillo EZ: one bought in a pharmacy in India (phisically in course of business tirp) and one ordered by Jagdish. Neither of them seems to work for me, in contrast to Nexlizet. I will try a full pill of Brillo EZ, as @DeStrider suggested, and if thereâs no impact, Iâll switch back to Nexlizet.
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PBJ
#91
Interesting. I would have assumed excessive heat in shipping caused the issue, but maybe the product is of poor quality or inconsistent.
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That would most likely be my guess. Usually drugs are way more resistant that people or labs can tell, mostly to sell more new when older expire.
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Satchel
#93
I am trying to purchase Brillo EZ / Bempedoic acid but the Indian pharmacies recommended for Rapa donât appear to carry it. Is it possible for someone to post a link for Brillo. 2nd question-do they sell a Bempedoic acid with ezetimibe?(ie Brillo.)
thx in advance
I ordered mine from Keshavdas and sons. They can have every med in India basically, and shipping in fast to France -7/10 days-. Really recommend!
I ordered Brillo from Jagdish in December and received it a couple of weeks ago.
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Both Maulik and Jagdish sell Brillo EZ.
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Satchel
#97
I am sorry to ask, but could you post a http link for me? Google searches for Maulik and Jagdish were very unhelpfull-I realize it is my inability to nail down the right search terms!
Just search here in the forum. Click on the magnifying 
in the upper right corner of the screen to do searches.
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