#21

Well it also doesn’t look like you’ve got any more fat to lose :muscle:

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#22

I’m currently 2lb heavier than when I graduated HS. Pretty happy with where I’m at weight wise.

I do need to get back at the resistance work but I’m doing an experiment and will be stopping the Sloop tomorrow as I’ve started Follistatin 344 today.

I’m interested in exercise memetics to see if they can counteract sarcopenia. I already know exercise will help with that but I want more than basic help :slight_smile:

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#23

Damn stud…
Like night and day… impressive.

Take your shirt off… :wink:

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#24

But then all my lost fat wrinkles might turn the ladies (and some guys) on and I don’t want that responsibility…

LoL!

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#25

This peptide has been exploding in popularity in recent months. I’m not taking it yet but I’m following along for now.

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#26

Steve, weren’t you also taking Ipamorelin/CJC1295 or one of its analogues? What gave you the best results? With or without working out?

#27

When I add something “new” I try not to change any of my baseline, unless there is a contraindication due to the addition. My thought on that is, all that has worked to date shall continue at X and then we will add Y and see what X+Y does.

I’ve been taking a combination of CJC1295 noDAC (250mcg) + Ipamorelin (400mcg) 5 nights a week for 15 months, with a week off every 2 months.

I was not doing this for any “gains” but as part of my modified TRIIM protocol.

My problem is that I do quite a few interventions and can’t fully separate results. We’ll call this the “Bryan J” syndrome, without the testing LoL!

Growth hormone is not strongly anabolic in people with normal hGH levels, and studies indicate it is not great at increasing strength but may increase muscle volume. It does support lipolysis and collagen production.

I think it did help my 69 year old skin shrink a bit better while losing the 55lbs. But my elastin is doing what elastin does for everyone, and there is nothing that can be done about that.

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#28

For fun, I ran this query with OpenEvidence AI (Note: I am leaving out the more extensive calculation for brevity)
To estimate the dosage range for SLU-PP-332 for a 6’ 2" middle-aged male with a Body Mass Index (BMI) of 22, we need to convert the effective dose from mouse models to human equivalents. This process typically involves scaling based on body surface area (BSA).

For a 6’ 2" male with a BMI of 22, the approximate weight is 77 kg (170 lbs).
Thus, the estimated human dose would be:
Total HED=0.81 mg/kg×77 kg≈62.37 mg/day
Therefore, the probable effective dose for a 6’ 2" middle-aged male with a BMI of 22 would be approximately 62 mg per day.
It is important to note that this is a rough estimate based on preclinical data and hypothetical values. Clinical trials are necessary to determine the safe and effective dosage for humans. Always consult with healthcare providers for personalized medical advice.

If this is true, I can’t afford it.
Perhaps some of the more medically educated members might do some more research and give an opinion on whether or not this dose seems accurate.

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#29

The sloop dosage equals the recommended amount of protein for me, a 140-lb male with a BMI of 21 or less. The recommended dose is about 62 g/day. I find this amount to be adequate. I don’t want sarcopenia, nor do I want to overload the kidneys.

I personally have no interest in an exercise mimetic. I like exercise. I enjoy it. A mimetic would be like taking a pill for speed reading or speed sex.

1 Like
#30

That would be a significant injection for me 65kg x 4mg = 260mg!! twice daily!

This does not mean this is the “effective” dose though. It does show a level of safety in mice for a short use cycle but this dose is used on mice to see an effect as quickly as possible.

Other studies of ERR agonists have used much lower doses.

I’m off Sloop in the short term but will circle back to in in a couple months as I continue my personal eval of Follistatin 344. Which has it’s own issues for efficacy.

A bit more info on SLU-PP-332 - this is a PDF download

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#31

There are many benefits from exercise that are not always visible with respect to muscle mass and it appears that SLU-PP-332 provides some of those hidden benefits and perhaps, as we age a little enhancement of those benefits, while exercising, might be a good thing.

From the linked study.

SLU-PP-332 administration mimics exercise-induced benefits on whole-body metabolism in mice including increased energy expenditure and fatty acid oxidation. These effects were accompanied by decreased fat mass accumulation. Additionally, the ERR agonist effectively reduced obesity and improved insulin sensitivity in models of metabolic syndrome.

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#32

Well, consider the millions who cannot exercise for whatever reasons.

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#33

Despite the category of molecule, it’s not meant to replace exercise, it enhances your body’s adaptation to exercise and improves exercise performance.

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#34

As we know, the doses used in mice studies don’t always convert appropriately to best doses in humans. Based on listening and reading testimonials of people who have been using it for a while, the minimum effective dose seems to be in the range of 200 mcg two or three times a day (600 mcg) total. Some people have pushed the three dose per day all the way up to 1500 mcg to see if additional benefit is felt. Still expensive at current pricing but not as as expensive as 62 mg a day :wink:

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#35

Great. Does it prolong lifespan (in mice)?

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#36

In my opinion life span in mice is over rated as a marker. But there are indications it can improve health span in aged mice.

Health span in humans on the other hand is a relevant marker.

Since Sloop has not had any human trials yet, we don’t know how it translates to humans.

https://ajp.amjpathol.org/article/S0002-9440(23)00321-8/fulltext

Results

ERRα and ERRγ Expression Is Decreased in the Aging Human Kidney

Decreased expression of ERRα and ERRγ in the aging mouse kidney is reversed by the dual farnesoid X receptor–Takeda G-protein–coupled receptor agonist INT-767 or CR.12 Furthermore, increased ERR expression correlates with increased mitochondrial biogenesis and function in the treated aging kidneys.12 In light of the role of ERR in mitochondrial biogenesis, the current study determined whether decreased expression also occurs in the aging human kidney. Immunohistochemistry was performed with human kidney sections from young (<20-year–old) and old (>70-year–old) individuals (Supplemental Table S1). The results indicate that both ERRα and ERRγ were expressed in renal tubules and that their expression levels were markedly decreased in aging human kidney

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#37

For people who are really interested in this topic, I can recommend this video;

3 Likes
#38

The challenge for me is determining which of these companies we can truly trust. Many expensive supplements often lack the ingredients they claim to contain.
Any tips for Europe?

Thanks

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#39

That is an issue. All the companies are small unknown brands

1 Like
#40

I got mine from Amino Asylum. They seem to have a good reputation from what I’ve heard (no affiliation).

1 Like