#121

Sorry, mis-read your post :slight_smile:

As you have noted there is not a lot of human data on this specific ERRa.

There is a fair bit of interest in ERRa’s though, due to the potential benefits

This is one of the earlier articles I can find on SLU and the link to other studies that reverence this one.

https://pubs.acs.org/doi/10.1021/acschembio.2c00720#

This one may be the first one published

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#122

Instead of looking for its exercise enhancement, the extra energy it may or may not provide, I think I’ll continue to take it at moderate doses and see if it has an effect on metabolic disorders. Many of these increase with age and are easily measurable with a blood test.

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#123

Since you are interested, I have been on Retatrutide for seven months now (1mg MWF so 3mg per week for the vast majority of the time). I am certainly continuing to feel the effects of a reduced (but not suppressed) appetite, which is great since I am not tempted to over-eat anymore. I am still looking more or less the same from a physique standpoint. My resting heart rate continues to be higher by about 10bpm, which I have just accepted.

I have to get some blood tests of Wednesday with an endocrinologist so I can get my TRT prescription renewed, and will ask him to add some things to check to see if there is a noticeable change in my lab work.

I don’t know if you recall, but I had an echocardiogram once month after starting retatrutide and my left atrium measured smaller than usual (which is good in my case), so that could be a result of reta or a result of the technician just measuring it differently since there is always some variation.

Either way, I plan to be on it indefinitely. I just ordered a whole bunch more. I feel good.

To get back on topic, I am really starting to become more interested in SLU-PP-32. The anecdotes people have mentioned about improved lab work is really what catches my attention. Claiming more energy doesn’t really sway me but improved labs does.

#124

I too have noticed a general increase in resting HR, about 6 BPM on average. I just got an Oura ring and my HR during sleep never gets below 73 and it’s only that low for a short time. I don’t know what my HR during sleep was before (didn’t have the Oura) but my resting HR while awake was around 68 pre Reta and now averages 73.

#125

I am wondering if it has an effect on body temperature, which wouldn’t be so noticeable when the air temp is 45 degrees but could more pronounced in the middle of a heat wave. I also take febuxostat for uric acid, which could be a confounding factor, since fever is a potential side effect of febuxostat.

#126

Your small bump in RHR seems a reasonable tradeoff if you’re getting a benefit from reta. For me, and my friends who have Oura rings, the lowest sleeping HR is much lower than the waking RHR. My resting RHR is typically in the low 70s, but my sleeping HR was in the high 50s at its lowest point. I have no idea how to interpret your high heart rate while sleeping, but perhaps others have experience or research with that.

#127

Yes, this makes it more interesting, but I’d have to know the details of what blood work, the baseline, and new values. Let us know if you come across this!

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#128

Thanks for the update! Please share what lab updates you are doing and the results. Inquiring minds want to know : )

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#129

What made you decide to get an echocardiogram? I had my coronary calcium score evaluated, but not an echocardiogram.

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#130

I spent a few years with hypertension in my 20s doing stupid things, so my heart enlarged a little. Enough to scare me into becoming interested in health & longevity. I get annual echocardiograms now.

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#131

Have tried few and I get near zero effect on pain relief and exercise recovery from the peptides I’ve tried. Do you mind sharing which ones you think worked for you?

#132

Do you have any side effects at that dose?(1mg every other day sounds interesting) I tried Reta a while back 5mg once weekly and was good for losing weight, but did make me tired (noticeably). And did you lose any weight at that dose, or you weren’t looking to lose weight?

#133

Resting heart rate higher by about 10bpm. That’s my only side effect. It does not cause me any fatigue at all.

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#134

Let me refer you the long thread on “Pepetides and Bioregulators,” which has a wealth of information. You can find it with the search function. I quote my most recent post:

“For me, TB Frag (1-4) is more effective than TB-500, the final seven-AA sequence, and more effective than the full 43-AA peptide. Dosing Frag (1-4) at 500 mcg per day keeps me pain free for a month, and then I cycle off for a month, during which the pain relief continues.”

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#135

Can someone confirm that exercisemimic.com sells legit slu-pp-332? Did anyone purchase from there? Any other good EU sources?

#136

I was a bit slow at getting this started but I’ve been taking 50mg in one oral dose since Tuesday, July 15.

One thing I have noticed is a bit of anxiety? or tension? about 30 minutes after the dose. It goes away in about 15 minutes. I’ve checked my resting HR when that happens and it’s typically 56 BPM. My blood pressure is also my normal numbers 99/60 when that happens. So I’m not sure if it’s an acclimation thing or what it may be.

I’ve got one other person in my circle doing this and he has not noticed anything negative like that but is super happy with how he feels and has found some extra energy.

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#137

There are several clinical trial doses, some for results, some for safety. SubQ was used for the safely eval. 40mg per day for 12 weeks and then off for a period of time and back on.
https://www.sciencedirect.com/science/article/pii/S1098360024000716

One trial for efficacy they used an IV drip over 2 hours with a "x"mg per kg of bw per hour. Based on that one, I’m going to do 16mg SubQ twice a day until my 1gm is all gone.

32mg x 7 = 224mg > 1000mg / 32 = 31.25 days

I plan to do this in August when I finish my 50mg per day of SLU-PP-332 experiment, now in my second week of that one.

If anyone wants to try a 50mg daily test of SLU-PP-332, let me know and I’ll provide a months worth for the cost of shipping. The “bro-science” dose of 250mcg to 500mcg 2 to 3 times a day isn’t doing anything for me. Oddly, I have several local people who swear by it.

Even taking 100 times the max Bro-Dose every day I’m still not sure, My muscles are may be a bit firmer, I did feel like I had a “pump” in my back the other day and I had not done anything that would have physically provided a pump but I’m still not sure. I’ve got 1 other guy doing 50mg a day.

For reference this is the equivalent of 2 low Bro-Dose bottles per day. Bottles they charge $80 for LoL!

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#138

Good luck, brother. You’re a brave man.

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#139

I ordered from there. Whether it is legit or not I do not know. I ordered the “super extra strength” 200mcg per drop.

I swear I notice a slight difference when I do 200mcg daily consistently. But I often take breaks because I don’t know enough about SLU-PP-332 to want to take it consistently. It’s probably the “craziest” thing I take.

How is 50mg making you feel?

#140

Not sure, I think I have noticed some muscle tone, Nothing much other than that so far but it’s only been about 2 weeks.

I was taking 500mcg 3 times a day for a couple months previously.