My blood markers were very good before Rapa and did not improve on Rapa. Still, I have eliminated allergies (mild), dramatically reduced joint pain, and have a reason to hope that my immune system improvements will also result in other improvements that will extend my healthspan.
On the blood marker point, I just recorded a podcast Dr Austin Baraki (of Barbell Medicine) on the imperfections of blood tests so no one should take these blood marker calculators as more than directional (at best). I’ll publish it in August.
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Oddly, rapamycin has had nothing but negative effects on my glucose and lipid markers.
I have experienced many positive effects from rapamycin that I have listed in other threads.
So, I use supplements and drugs to keep my glucose and lipid levels down to my pre-rapamycin levels.
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Metformin, Bempedoic Acid and Ezetemibe have countered my hyperglycemia and hyperlipidemia from Rapamycin almost perfectly.
However I wish my HBA1C (5.4) and LDL (65) were still lower…
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jnorm
#24
I took a blood test on 9/19/23 and then, almost a year later on 9/17/24 I tested again. During that year I spent 6 months on a pulsed rapamycin schedule and 6 months off.
Unfortunately my 23’ test wasn’t very extensive, but majority of markers trending in right direction. Glucose went from 94 to 91, LDL from 95 to 83, triglycerides from 58 to 44, IGF-1 from 191 to 178, E2 from 25 to 28.9, and eGFR from 108 to 119.
RDW trended in the wrong direction (12.5 to 13), and NLR increased as well (1 to 1.27).
Ofc it’s impossible to say these changes are due to rapa, and most of them probably aren’t outside of normal fluctuations, but fwiw rapa was the primary longevity drug or supplement I took over the past year. I also hadn’t taken rapa for months leading up to the 2nd test. I did take taurine daily for the past year and glycine for a few months, and briefly used acarbose as well.
One other thing worth mentioning is that I developed a bit of an opiate habit over the past year, that mostly stemmed from a relationship ending. This started with a few months of using kratom daily, which I then quit. However, I then switched to taking 7-HO-mitragynine daily, which is something I’m now eliminating from frequent usage. No idea how this may have impacted biomarkers, although the kratom seems to be more harmful. I found it to cause hair shedding and poorer skin quality which was why I stopped taking it, and I found many similar reports on Reddit. It’s unclear what the cause is, although some have speculated it’s due to heavy metals. 7-HO-mitragynine (which is a minor alkaloid of kratom, and probably the primary pharmacological mediator of its opiate effects) doesn’t appear to affect hair or skin quality.
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