Pre Rapamycin Lab Work Recommended?

[Sasa_Loncar]

Hey Guys.

Thinking about starting Rapa this month.

Gonna go slow, 1/2/3… weekly just in case.

My question is: what blood work prior Rapa to take?

Thanks in advance!

[RapAdmin]

Hi Sasa, welcome to the forum. That’s a great question. The more data the better - so its partly budget related, how much do you want to spend?

I would think at a minimum you want to track similar blood work as is being done in the PEARL rapamycin trial - see listing here on the bloodwork and comment by participant. My understanding is that they are doing these measures:

Complete Blood Count (CBC), comprehensive metabolic panel (CMP), lipids, insulin, A1c, Vitamin D, DHEA, uric acid, C-reactive protein (CRP).

Many of these are available for about $35 as listed here (other labs to check on for pricing are walkinlabs, Ulta Labs (ultalabtests :

Chemistry Panel CBC | Blood Test - Life Extension

C-Reactive Protein | Blood Test - Life Extension

Part of the goal would be to do a pre-test Levine phenotypic age calculation as outlined here:

A Friendly, Biological Age Reduction Competition?

[bioage2] What do you think about the idea of a friendly, “biological age reduction” competition that helps us all get healthier and more knowledgeable… This week I saw that one person has reported great results with rapamycin in terms of biological age reduction: Has anyone lowered their levine age or aging.ai through Rapamycin? yes, had blood tests and epigenetic age test done before starting rapamycin and after. Took rapamycin at 6mg/week for 4 months. 13 years improvement by Levine calcs as well as epiagingusa test. To be honest, I’m very surprised by this result because the study on the rapamycin treated marmosets showed negative results. But - as many researchers pointed out - it was one type of epigenetic test (and in general people are still questioning the value of these te…

Perhaps tests like these:

IL-6/IGF-1 | Blood Test - Life Extension

and Dexa scan to check on your lean body mass:

https://www.bodyspec.com/what-is-dxa

https://www.dexafit.com

I also recommend you check out these past discussion threads related to the issue of blood testing while on rapamycin:

What blood tests are people taking?, Any rapamycin specific ones?

How to get a Rapamycin (sirolimus) Blood Level Test

Rapamycin / Sirolimus Blood Test - My Results

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Also - if you are relatively new to rapamycin, I recommend you review our FAQ (Frequently Asked Questions) - lots of good information from other members there:

Rapamycin Frequently Asked Questions (FAQ)

[RapaFAQ] Rapamycin: The Gold Standard of Life Extension Drugs Rapamycin is by far the world’s leading candidate for an effective and accessible anti-aging drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of people already using it to improve their lives. At a minimum, you probably want to learn as much as you can about it and keep a close eye on the research going forward. Rapamycin is considered by many geroscience researchers to be the “gold standard” of anti-aging drugs; the lifespan improvement seen in animal trials are consistently the best of any drug (15% to 30%). It increases healthspan and lifespan in every organism its been tested in - from yeast, to flies to worms to mice (over a billion years of…

[Agetron]

You might want to do an epigenetic test to see if your DNA methylation changes… improves.

Gives you a baseline fir noting changes.