Prevent and cure cancer

[RapAdmin]

[AnUser]

I asked ChatGPT with reason and search (o3-mini) about this with good evidence and it suggested a couple of preventative strategies:

Breast cancer: tamoxifen, raloxifene
Prostate cancer: finasteride, dutasteride
Lung cancer: smoking cessation
Colorectal cancer: aspirin

Liver cancer: hepatitis B vaccine or antivirals with chronic infection.

Seems legit, prompting matters a lot. I used Claude 3.5 to help create the prompt.

[Bicep]

My daughter has been looking at these glucans and whether it is a reasonable strategy, both for cancer and infectious disease:

1327.full.pdf

I’m in over my head. Does anybody have thoughts? Seems like for somebody that doesn’t have cancer it would cause inflammation?

[Davin8r]

@Bicep

Seems like for somebody that doesn’t have cancer it would cause inflammation?

Apparently the beta glucans generally have anti inflammatory effects, even as they can enhance immune function, but of course it’s complicated. Dr. Oracle seems to have a reasonable summary:

Question: Does beta glucan increase inflammation?

Beta Glucan and Inflammation: A Complex Relationship

Introduction

Beta glucan, a polysaccharide found in various sources, has been the subject of numerous studies investigating its effects on inflammation in the body. The relationship between beta glucan and inflammation is complex and context-dependent.

Anti-inflammatory Effects

Reduction of Pro-inflammatory Cytokines

Beta glucan has demonstrated the ability to reduce pro-inflammatory cytokines in several studies:

• In a mouse model of inflammatory bowel disease, dietary beta glucan reduced the expression of pro-inflammatory cytokines (21434779)
• Beta glucan treatment in sepsis-induced lung injury completely blocked the elevation of TNF-α, IL-1β, and IL-6 (17414422)

Attenuation of Inflammatory Responses

• Beta glucan administration led to less inflammation within the colon in IL-10 deficient mice (21434779)
• In ob/ob mice, yeast beta-glucan decreased pro-inflammatory modulators such as TNF-α, IL-6, IL-1β, CCL2, and SAA3 (29285925)

Immunomodulatory Effects

Enhancement of Immune Function

While beta glucan can reduce certain inflammatory markers, it also has immunomodulatory effects that may enhance immune function:

• Beta glucan acts as a biological response modifier, promoting dendritic cell maturation and cytokine secretion (37376063)
• It can stimulate immune responses while simultaneously inhibiting inflammation (29285925)

Regulation of Gut Hormones

Beta glucan consumption influences gut hormones, which in turn can affect immune responses:

• Enriched beta glucan food consumption influences levels of peptides such as YY, ghrelin, and glucagon-like peptide 1 and 2, which can impact innate and adaptive immunity (28964548)

Considerations and Caveats

Dosage and Source

The effects of beta glucan on inflammation may vary depending on:

• The source of beta glucan (e.g., yeast, cereals, microorganisms)
• The dosage and duration of administration

Individual Variability

• The impact of beta glucan on inflammation may differ based on an individual’s health status and underlying conditions

Potential for Increased Inflammation

While most studies indicate anti-inflammatory effects, it’s important to note that:

• In some contexts, beta glucan’s immunostimulatory properties could potentially lead to increased inflammation in certain individuals or conditions

Conclusion

The evidence suggests that beta glucan generally does not increase inflammation in the body. In fact, it often demonstrates anti-inflammatory properties. However, its effects are complex and can vary based on the specific context, source, and individual factors. Further research is needed to fully elucidate the relationship between beta glucan and inflammation in various health conditions and populations.
[Answer generated by www.DrOracle.ai]

[Davin8r]

Sources for the above AI search (unfortunately I can’t get rid of those two icons partially blocking the final reference):

[Bicep]

Thanks for doing this, it helps quite a bit. Hard to believe it actually works. I still have reading to do.

[KarlT]

Removal of fallopian tubes almost completely eliminates women’s chance of ovarian cancer.

[RapAdmin]

Pancreatic cancer linked to obesity, high fat diet and high stress levels

Researchers at University of California Los Angeles (UCLA) found that stress-related neurotransmitters and obesity-related hormones activated CREB (cyclic AMP response element-binding protein), which was shown to promote the growth of cancer cells in the pancreas.

In the study, mice that ate a high-fat diet were more likely to develop precancerous lesions. When stress levels were also raised through social isolation, the lesions grew even more.

The stress-related cancer risk was more pronounced in female mice.

Based on these findings, the researchers suggested exploring the use of existing medications to reduce the risk of obesity- and stress-related cancers.

Deadly cancer type linked to obesity and high stress levels

Chronic stress and obesity work together to accelerate pancreatic cancer...

Research Paper:

More information: Xiaoying Sun et al, Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer, Molecular Cancer Research (2024). DOI: 10.1158/1541-7786.MCR-24-0785

[mccoy]

I asked Deepseek for a concise explanation with scientific articles on the immunomodulatory effect of Reishi mushrooms. That’s maybe the most effective medicinal mushroom (for prevention) if you must choose a single one.

Reishi mushrooms (Ganoderma lucidum) exhibit immunomodulatory effects through bioactive compounds like polysaccharides (e.g., β-glucans) and triterpenes. These components regulate immune responses by:

1. Enhancing Immune Activity:

   • β-glucans bind to immune cell receptors (e.g., dectin-1, TLRs), stimulating macrophages, natural killer (NK) cells, and dendritic cells, boosting phagocytosis and cytokine production (e.g., TNF-α, IL-6) [1,2].
   • Polysaccharides increase T- and B-lymphocyte proliferation, enhancing adaptive immunity [3].

2. Suppressing Overactive Immunity:

   • Triterpenes inhibit pro-inflammatory pathways (e.g., NF-κB), reducing excessive cytokine release and inflammation, potentially aiding autoimmune conditions [4].

3. Balancing Response:
   Reishi modulates Th1/Th2 balance, promoting appropriate immune reactions depending on physiological needs [5].

References:

1. Batra et al., J Pharmacogn Phytochem (2013) – Medicinal properties.
2. Lin et al., Int J Med Mushrooms (2003) – Cytokine induction.
3. Wachtel-Galor et al., Herbal Medicine: Biomolecular and Clinical Aspects (2011) – Clinical effects.
4. Cheng et al., Phytochemistry (2010) – Triterpene anti-inflammation.
5. Jin et al., Int Immunopharmacol (2016) – Dendritic cell modulation.

(For full access, consult the cited journals or books.)

[Neo]

https://www.nejm.org/doi/full/10.1056/NEJMoa2407934

[adssx]

If one has already sequenced their genome, can they calculate this score by themselves? Or is it proprietary / unpublished?