#127

I disagree on Vitamin D. By their criteria it cannot be higher than a B. Now I believe it will eventually be an A , but the data doesn’t support this currently.

I spent 10+ hrs researching the blog and writing this … so I’m pretty confident on that item.

Tend to agree w @KarlT with other stuff

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#128

I am an expert on my opinion lol. He’s an expert on his opinion. But since he’s on YouTube he is essentially selling his opinion and we get to critique it. I am finding that the wider he goes the less impressed I am.

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#129

Thanks! Great blog post on Vitamin D. My tested level was 30 and I’ve been supplementing with 800 IU daily but now I’ll up my supplement to 3000 IU and retest til I get to at least 40.

https://www.grantfrasermd.com/post/neurocognitive-decline-series—vitamin-d

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#130

I learned things researching this as the “party line” is supplementation doesn’t change outcomes. I now think that is wrong.

Also @adssx helped me tidy this up and added some important items!

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#131

The question on vitamin D is what the ideal serum level is. This raises a question as to whether it should cycle during the year. My theory is that the reason many creatures have a metabolism where gene expression is dependent on levels of 25OHD in blood serum is that this enables them to fit their metabolism more closely to food availabiltiy.

Hence it is possible that there is a merit in an annual cycle of vitamin D levels. However, personally I go for just keeping it in the high of normal range. (although it is oscillating a bit because of me varying the supplement regime quite a bit at the moment).

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#132

@Krister_Kauppi - here is more color on some of this: Rapamycin Dose-Effect Relationship - #8 by Neo

It seems to me this is one of the most important questions for a healthy person taking rapa. Do you think you could ask him this question ? It also less of a repeat with other things he has discussed in the past.

@DrFraser do you have any thoughts on this?

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#133

I’m not sure mortality is the only thing to follow, as some days seemed to favor over 50 for neuro cognition. This bit of cushion also helpful for winter

#134

@DrFraser did you look at this study?

image

#135

“since he’s an expert in one area, he considers himself an expert in a much wider area.”
“Since he’s an expert in one area, he is an expert in a much wider area.”
This may or may not be true.

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#136

Don’t think we have discussed this paper? Not the best, but perhaps worth a skim

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

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#137

You are correct or incorrect. ; )

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#138

A very interesting question since many things no longer cycle for humans.

#139

@John_Hemming ive been nearing about mitochondrial differences between people who needed to generate body heat in winter (inefficient energy production) and only get sunshine during parts of the year vs tropical people who don’t need to generate extra body heat but are used to getting a lot of sunshine. If you live in an area with environment vastly different from your ancestors, you have problems. Maybe these problems can be offset somewhat by vit d.

#140

When you provide medical care for decades then yes, it certainly makes your opinion rank higher on relevance of medical interventions than someone that spent decades doing bench research. Most of the Earth’s population gets that concept and choses to go to a medical provider as opposed to a pure researcher.

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#141

The only thing most of the earths population understands are doctors narcissistic need to feel superior. Matt based he opinions on several factors, such as cost. Send me the link when you make ultimate longevity priority video.

#142

@ng0rge I loved doing the research on this, as I was challenged by multiple colleagues on why I was supplementing people for no reason, and then in my chat with Matt K I expressed some reservation around why he would have this as a strong recommendation. Incidentally, I think he is right on this one … I just don’t think we have the clear evidence yet – but if someone would do the right study, I think the evidence will be there. Thanks for reading the blog … it is really long, but I think putting things in context is really important on this topic.

@John_Hemming This is a fascinating issue of whether we do harm to blunt seasonal variation by supplementing. This is where I think the best situation is to try for 3 months to do what you can behaviorally, and then supplement if needed. In this situation, you simply move the curve upward on your level, above a minimal harmful threshold, but should continue to have highs in summer and lows in winter.

@AnUser - I think all cause mortality is a really important outcome. However we have 60,000 IU monthly given, and just don’t know what their levels were. They weren’t selected or monitored based upon deficiency. We know people with high vitamin D levels have worse outcomes - again, it is a serious methodologic error to just blindly supplement when it is so easy to test levels and target to a certain level.

@KarlT - really interesting, I agree, many things that used to cycle, we’ve eliminated by our hardship and environmental changes.

@Dr.Bart Clinicians rule and researchers drool … well they are pretty smart, it’s just a different animal and perspective

@PBJ I think the experience that doctors are narcissistic is unfortunate. I’ll apologize for doctors if that is what you’ve experienced. I’m not, and learn a stack from my well educated patients (less from my patients in the ER).

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#143

@DrFraser It seems you’ve also mastered a happy/optimistic personality (at least in your writing :wink: ) That should add an extra 5-10 years of healthy lifespan. :slight_smile:

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#144

I have contacted them and created a google sheet which I sent to them and tried to group the questions in a good way because this will be multiple episodes with all the questions we have. I have also added your question to the sheet now.

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#145

So you judge people by their ability to produce a “video” :rofl:

Send me a link when you finish a medical school, residency, fellowship, all the licensing exams and spend 25 year providing medical care.

Feel free to put me or any other “narcissistic” providers on the ignore list. Clearly we don’t meet your “standards” for expertise, so why bother being exposed to our opinions?

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#146

Thanks for proving my point.

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