#41

You are never too old to start Rapamycin. My father started at age 77. Dr. Green started around that age as well. As long as you have a pulse (and are over the age of 25) it’s OK to take Rapamycin.

Note: It may be harmful to diabetics to take Rapamycin due to results from studies on diabetic mice.

So older than 25 yo and non-diabetic individuals should be OK to try Rapamycin. There may be other side-effects that may be intolerable but this is up to each individual person’s unique biology.

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#42

The idea for metformin came from the fact that when I was sick with Covid just before my second myocarditis episode, and my disabled brother-in-law who lives with us was also sick (he developed gastroparesis), my husband who takes 2,000 mg metformin for diabetes, didn’t have any symptoms or test positive. I did some research and found studies showing that metformin reduces the risk of post-Covid complications as well as all cause cardiovascular mortality, at least in diabetics. I also found information about the potential health and longevity benefits of metformin on Peter Attia’s site.

After 3 weeks of metformin 500 mg twice a day, the chronic vasculitis-like symptoms that started after my second episode began to improve and mostly resolved after a couple of months. The reason I know it was the metformin is because I developed gastro issues and had to stop, and the symptoms returned within a month. I restarted the metformin, and the symptoms improved, again around the 3-week mark. I went off due to gastro issues, they reappeared. Now I’m taking 750 mg of the ER version twice a day with no gastro issues and plan to continue indefinitely.

I think I had Covid (or the worst flu of my life) in February 2020 before there was any testing available, and really before anyone acknowledged that it was already rampant throughout the NYC region. Other than that, I’m not aware of having Covid before the vaccine.

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#43

My husband is diabetic with out-of-control glucose for the last several years. Got it under control with diet, exercise and acarbose, then started rapamycin, and all his markers are great and continue to improve.

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#44

the answer is much simpler than that. 1mg daily is the dose UTH San Antonio used for all their human studies. So this is the dosing for the Alzheimer’s study. Has nothing to do with blood brain barrier permeability of sirolimus. In Joan’s vaccine study 1mg daily was similar to 5mg weekly

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#45

Another question for Matt:

How low is “low” blood sirolimus levels before the next dose of weekly rapamycin? What should we target for the trough levels of blood sirolimus testing?

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#46

probably better dosing regimen to induce compliance

#47

I did:) I don’t let age stop me in any regard. I have muscle pain, misalignment, fatigue, etc. but nothing I would blame on Rapa. Been on only about 4 months, at 5mg weekly. No symptoms or reactions whatsoever. Female, way post-menopausal, active, keto/IF.

ginny

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#48

Possible Question:
What studies have there been as to the effect of rapamycin on cell division relating to stem cells more generally. There is evidence that Rapamycin reduces nail growth. It is known to hold back cell division as that is the mechanism that gives it the ability to prevent rejection of kidney transplants. Hence it should have a point at which it is reducing stem cell production. What studies are there on that and what does it indicate for dosing both frequency and amount?

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#49

Interesting regarding the nail growth. You mentioned there exist evidence that Rapamycin reduces nail growth, do you have a study supporting this. Curious to read this.

This is aligned with anecdotal report from Peter Attia. Here is a time clip where he mentions it.

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#50

I started a topic on it yesterday

I was wondering what was the factor that caused some people’s biomarkers to go backwards at a higher level of rapamycin. I think this is probably it although obviously immune issues can be as well.

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#51

For Matt:

Should we keep weight in mind when figuring out our individual doses?

I realize no one knows at this point, but perhaps you can assist us with putting together a rough guide, with the caveat that it’s experimental?

It’s been suggested that 6mg is a good target dose, and it’s what my doctor prescribed.

Where did this 6mg suggestion come from?

Can I assume this is for the average sized person, and if so, what does this average person weigh?

If we take one’s weight into the equation, how many milligrams might we consider adding or subtracting for each, let’s say, 10-20 pound-ish difference?

I realize the dosage for many medicines and vaccines are not weight dependent, so how we know when, or even if, we should be thinking this way?

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#52

Another 2 part question:

Is there any evidence of tachyphylaxis and/or tolerance to rapamycin over time?
And if so, would varying the dosage and/or frequency mitigate this from occurring?

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#53

@Dr.Bart Very good question. After almost 2 years on Rapamycin, it doesn’t affect me the same ways it used to. I’m not sure if that’s a good or bad thing. For instance, much fewer side effects both good and bad.

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#54

I find it odd that I’m constantly cutting my fingernails while I’m on rapamycin. And, my hair grows like weeds, I’m getting haircuts every 2 weeks and I’m cutting my nails at the same time. This was not typical pre.rapamycin, so that’s my N=1.

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#55

Think you boost some growth pathways - eg high testosterone? That might be part of the story here?

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#56

Definitely could be… need to add my nails are very thick… and healthy too. Look amazing.

Very different from my before Rapamycin dosing… and even since getting over toe fungus 1 year ago. Toe nails look fantastic. Like a much younger guy.

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#57

Nail growth requires stem cells. Hair growth is only protein.

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#58

Well I do max out on protein. Large quantities most days.

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#59

Stem cell creation needs a lot of protein as well. The main point is that if you have adequate nail growth then Rapamycin is probably not doing that much harm to stem cell production (or indeed the immune system). I have no idea where the balance lies in terms of the creation of lymphocytes vs other new cells, but we should expect rapamycin to affect a range of cell creation (including RBCs).

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#60

I wonder if rate of nail growth can be a metric for health or some element of health. From anecdotal evidence shared on this site it appears that rapamycin adjusts the immune system in some way that restores a more youthful tolerance of allergens.

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