#122

Cancer detection clearly an A.

Dexa and CGM don’t really fit into his categories. Do they work? Absolutely. But do you need them? I question that.

I think the problem is the Matt K. Has made the same mistake as others in that he has decided that since he’s an expert in one area, he considers himself an expert in a much wider area.

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#123

He shared his opinion. Do you have to be an expert to have an opinion? Are you an expert in opinions?

#124

I tend to agree but I personally find it useful to know what a smart well educated well connected person thinks about these things on which I struggle to separate marketing from science. I think he is hurting his credibility but I hope he continues to do it.

#125

I find it is useful that he gives a broader perspective. People who are experts in a narrowly defined subject tend to think that their area of expertise is perhaps more important than would be thought be experts more generally.

#126

One other key question to him is: What are your thoughts on how rapa can be combined with things that offsets the risk of decrease in mTORC2? Eg acarbose, fasting, 16-alpha, other?

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#127

I disagree on Vitamin D. By their criteria it cannot be higher than a B. Now I believe it will eventually be an A , but the data doesn’t support this currently.

I spent 10+ hrs researching the blog and writing this … so I’m pretty confident on that item.

Tend to agree w @KarlT with other stuff

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#128

I am an expert on my opinion lol. He’s an expert on his opinion. But since he’s on YouTube he is essentially selling his opinion and we get to critique it. I am finding that the wider he goes the less impressed I am.

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#129

Thanks! Great blog post on Vitamin D. My tested level was 30 and I’ve been supplementing with 800 IU daily but now I’ll up my supplement to 3000 IU and retest til I get to at least 40.

https://www.grantfrasermd.com/post/neurocognitive-decline-series—vitamin-d

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#130

I learned things researching this as the “party line” is supplementation doesn’t change outcomes. I now think that is wrong.

Also @adssx helped me tidy this up and added some important items!

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#131

The question on vitamin D is what the ideal serum level is. This raises a question as to whether it should cycle during the year. My theory is that the reason many creatures have a metabolism where gene expression is dependent on levels of 25OHD in blood serum is that this enables them to fit their metabolism more closely to food availabiltiy.

Hence it is possible that there is a merit in an annual cycle of vitamin D levels. However, personally I go for just keeping it in the high of normal range. (although it is oscillating a bit because of me varying the supplement regime quite a bit at the moment).

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#132

@Krister_Kauppi - here is more color on some of this: Rapamycin Dose-Effect Relationship - #8 by Neo

It seems to me this is one of the most important questions for a healthy person taking rapa. Do you think you could ask him this question ? It also less of a repeat with other things he has discussed in the past.

@DrFraser do you have any thoughts on this?

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#133

I’m not sure mortality is the only thing to follow, as some days seemed to favor over 50 for neuro cognition. This bit of cushion also helpful for winter

#134

@DrFraser did you look at this study?

image

#135

“since he’s an expert in one area, he considers himself an expert in a much wider area.”
“Since he’s an expert in one area, he is an expert in a much wider area.”
This may or may not be true.

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#136

Don’t think we have discussed this paper? Not the best, but perhaps worth a skim

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

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#137

You are correct or incorrect. ; )

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#138

A very interesting question since many things no longer cycle for humans.

#139

@John_Hemming ive been nearing about mitochondrial differences between people who needed to generate body heat in winter (inefficient energy production) and only get sunshine during parts of the year vs tropical people who don’t need to generate extra body heat but are used to getting a lot of sunshine. If you live in an area with environment vastly different from your ancestors, you have problems. Maybe these problems can be offset somewhat by vit d.

#140

When you provide medical care for decades then yes, it certainly makes your opinion rank higher on relevance of medical interventions than someone that spent decades doing bench research. Most of the Earth’s population gets that concept and choses to go to a medical provider as opposed to a pure researcher.

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#141

The only thing most of the earths population understands are doctors narcissistic need to feel superior. Matt based he opinions on several factors, such as cost. Send me the link when you make ultimate longevity priority video.