Dr. Ross Pelton on Tuesday, June 21, 2022. PEARL Webinar is one of the few experts addressing the issue of rising lipid levels. (I was directed to the webinar by"Agetron )
He suggests that if your cholesterol levels rise, your dose is too high and you should back off.
Symptoms of an overdose: anemia, low iron, elevated cholesterol and triglycerides levels.
Dosing and side effects at 25:50.
Since I have been dosing at rather high levels and my cholesterol has been much higher than my normal levels I think I will back off. Fortunately, I have blood tests taken over the years and just before taking rapamycin.
I didnāt actually recognize this as an adverse side effect when adjusting my dosage to the highest levels without adverse side effects.
This was a great webinar and covers several other anti-aging topics besides rapamycin.
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MAC
#449
This is a human imposed restrictionā¦how does this ātoo high limitā prevent our ultimate goal, lifespan extension in humans? The innate laws of physics, biology, science, in this case, longevity extension, do not care about external limits. Clearly, if standard playbook dosing protocol causes a reduction in mortality via side effects, this obviously defeats the purpose.
This is a massive unknown gap in translationā¦the elephant in the room.
Wait a minute. I thought you were in the lower is better camp.
You do know pessimists and cynics donāt live as long? Right? (LOL)
MAC
#451
No, I am in the higher systemic and higher in the brain whilst minimizing side effects via hacking delivery method (s). Maybe thereās another paradigm for rapamycin to optimize human longevity?
Iām an engineer/inventor/citizen-scientist, I am intensely curious at re-appplying myself to leverage biological science (not my training) for optimal health benefit. But a realist by nature; the facts, known and UNKNOWN, help ground my thinking.
But I agree with you, optimists do live longer. So hereās to rapamycin, the magic bullet!
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I believe that heās a pharmacist and may have a different perspective. I havenāt listened to the podcast but if heās generalizing like that and not taking into account the details, then I canāt agree.
First off, the Mendelian randomized study that I posted showed no significant risk for CAD from lipids if elevated after the age of 70.
What does he define as an elevation? To what extent and which lipid subgroup?
A drop in iron may be beneficial. How low is he talking about?
He may be correct but is there Any human study to support this advice?
MAC
#453
For Rapamycin, even Dr B says in a few of his papers that if lipids rise, take a statin. Dr B also says glucose should not rise but if it does, itās benevolent, but he demurs and says just take metformin.
This is standard lipids (and glucose) playbookā¦extended to a rapamcyin side effect, conventional cardiovascular disease management. And weāve already thrashed this subject for some time as to itās need/efficacy.
Your questioning the need for a statin is still valid, but you also come from a ādifferent perspectiveā and bias.
We do not know if Rapamycin alters the normal CVD dynamics. Two cardiologists might possibly disagreeā¦one who goes by AMA playbook vs one who looks at the entire risk profile, including say CAC.
By different perspective, I merely mean that itās not unusual for doctors and pharmacists to view certain things differently. Not that one is necessarily right. In fact, Iām usually wrong.
MAC
#455
Agreed, but I think your true inquiry is whether the perspective is grounded in some ārapamcyinā specific attribute or knowledge, or just standard lipids playbook of which you are completely versed.
I will venture to say itās the latterā¦standard lipids playbook because we truly do not know.
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I would agree. We certainly donāt know.
So before Rapamycin my LDL was above 130ā¦then since being on Rapamycin the past two years my LDL has gone up even higher (enough it was a topic at each 3 month blood review). It has stayed these numbers consistently.
With my Cardiac Calcium scoring of absolute 0 zero. Discussion of my LDL no longer a concern.
Before Rapamycin
After Rapamycin
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MAC
#463
Since we want you to remain ageless, and longevity is all about reducing all cause mortality, have you ever had a colonoscopy, youāre 62 yes?
Any family history? This is yet another very simple screening tool like CAC (ok, a bit more invasive!), and given your carnivorous diet (a major colorectal risk factor), highly recommend you get one. And yet, so FEW people get them as a screening tool. The earlier you catch it, the better your prognosis.
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Very interesting data. Thanks.
Once again lipids do not = death. They are 1 risk among many.
And by many
Smoking, BP, genetics, sleep, stress,exercise, air pollution, age, gender,diet, telomere length, diabetes, past history of heart disease, alcohol, Etc.
Iād love to be a fly on the wall when your PCP sees your labs and hears your diet. He/ she will be the one with the heart attack.
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I agree that the goal is to prevent all age related diseases. Prevention and early detection.
I like colonoscopy and also the yearly second generation FIT stool exam if colonoscopy is negative.
Mammograms are useful, but many false positives.
PSA and free PSA are less certain in my mind . Iām never sure what to make of the results. Many false positives. Might get a prostate MRI. Newer urine tests are encouraging.
Iām really thinking about Prenuvo screening. I heard about it some years ago on an Attia podcast. The false positives are very low and you can catch things very early.
All of that being said, I feel very confident that rapamycin is cancer protective to a large degree.
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Colonoscopyā¦ a bit invasiveā¦ brahaha!
So like my research with Rapamycinā¦ so was it with this procedureā¦ recommended at age 50 to 55 years?
Saw my wife go through thisā¦I was not about to have itā¦ had to be something better. No colon cancer or issues in my parents or grandparents living into late 80ās and early 90ās.
Researched Cologuardā¦ was almost as effective in detection of cancer as colonoscopyā¦talked to my doctorā¦ he thought I was nuts. But years of research was there. Wife told me to just do the colonoscopy! I said nope! Reluctantly he signed the order. My new physician padt 3 yearsā¦obviously listens to me, on TRT, Metformin and Rapa. Says my health is amazingā¦ the physical change ā¦2 different people.
Nobody knew what Cologuard wasā¦ much like Rapamycin todayā¦lol. FDA approved it mid-August 2024ā¦by Novemberā¦I was signed upā¦I was around Cologuard user 432. Yep!
Today it is standard screeningā¦ over colonoscopy. Because I was one of the firstā¦and it can be done every 3 yearsā¦ had my 3rd screening in February 2022. Negative.
In March 2022 another kit arrivedā¦ ??? Couldnāt figure out why I had another one ā¦ wifey saidā¦ āthatās her kit!ā Hahaha.
She got a positiveā¦ negativeā¦ had to do the whole colonscopy route. Karma.
Link:
https://www.cologuardhcp.com
https://www.cologuardhcp.com/about/clinical-offer?gclid=EAIaIQobChMIyoK7lPLI-AIVMhh9Ch1ZzgCMEAAYASAAEgI_HfD_BwE&gclsrc=aw.ds
So I will stick with Cologuard.
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Thereās something else Iām noticing in your data. Your granulocytes are at the lower end of normal. The major component of them are neutrophils. Neutrophils are necessary, but can be nasty and contribute to a whole variety of evils, including CAD, especially NETs
Rapamycin May have an inhibitory effect on neutrophils leading to suppression of the innate immune system and possibly increased bacterial infections. But, like everything with rapa, thereās a silver lining perhaps.
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