#21

I have been on and off on 1mg/day regimen over the past 2 years. No noticable blood work changes. I am inclined to stay with the practice mainly for the reason as we age, our MTOR is chronically elevated with an ever higher baseline per Dr. Brian Kennedy.

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#22

Hi Michele,
I’m a fan of LDN
but I think their mechanisms would be totally different. To my knowledge, LDN doesn’t inhibit mTOR
o induce authphagy.

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#23

Thank you Dr Ross. I am taking berberine on and off and I really like it, also fucoidan and astaxanthin.

#24

Very interesting! I too haven’t had a cold or flu since starting rapamycin about three years ago. Not even the first sign of one. Anecdotal testament to its immune enhancement effects I do believe.

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#25

Same here. Not only cold/flu but even allergies(which used to be bad during spring) have seem to abated. Didnt use flonase for two years.
Quite perplexing though for me is that fact that IGF-1 has gone up from baseline of 74 to 114 agter nearly 7 months of weekly Rapa use!! I do 24 hr caloric fast starting with the dose.
For those of us on weekly Rapa with GFJ hack, how will daily dosing work while rationing Rapa stocks
hahaaa?

6 Likes
#26

Yep
 it is now the season of ragweed. And, as to allergies
 nada past 3 years. Has to be the rapamycin.

Never had allergies until I hit 50 years old. I used flonase for ragweed in fall and cedar spores in spring.

I was on flonase back when it was still gotten by prescription. FYI - flonase went off prescription July 24, 2014. Over 11 years ago.

My wife first started getting allergies a bit before me maybe at 46 years. She isn’t on rapamycin or flonase
 and she continues to get and complain about seasonal allergies. So I know the environment hasn’t changed.

Rapamycin rebuilds the immune system, so I am back to my pre-50 year old immunities issues. Which were none.

Just one of my markers for rapamycin is working.

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#27

does it reduce 8oxog?

#28

Greetings
The rise in your IGF-1 levels may actually reflect better health.
See the attached reference, figure 3a, which plots all cause mortality risk vs IGF-1 level.
The curve is U shaped, with the most favorable IGF-1 level being 140.
Hope that helps

Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis - Rahmani - 2022 - Aging Cell - Wiley Online Library

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Rapamycin induced insulin resistance and drop in testosterone
#29

Excellent paper. That’s the kind of metanalysis I was looking for. Reassuring for me to say the least! Although, what remains unclear is how Rapa would fit in this equation for my IGF-1 trends.
U-shaped association seems intuitive just like many other nutritional markers which tend to be J or U-shaped.
Thanks for sharing it.

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#30

I still get sick even with Rapa 10 mg equivalent weekly. HOWEVER, the intensity of the illness is greatly reduced. I used to get hacking coughs that would last up to 6 months. Now they typically resolve in 1 month or less. I still get COVID every year in the Spring, but it’s less troublesome than the flu nowadays.

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#31

A news article on this research paper:

Ghada Alsaleh, a postdoctoral researcher at the University of Oxford, explained that rapamycin consistently produces the same effect, whether it’s given before, during, or after the damage occurs.

Study co-author Lynne Cox said the effect happens rapidly – within about four hours it appears to influence the DNA damage response and the buildup of lesions.

A cautious endorsement

Matt Kaeberlein at the University of Washington sees the study as strong evidence that rapamycin protects DNA. Yet he emphasizes the mechanism remains a mystery. The next step is to track how the drug changes RNA and protein activity inside immune cells.

In a pilot study, older men given low-dose rapamycin showed less DNA damage in their immune cells without harming overall immune function. This is a critical finding, according to Cox.

Even more intriguing, a longer trial revealed that rapamycin reduced senescence marker p21 while raising levels of p53, a protein that not only manages DNA damage but also fuels mitochondria, the cell’s energy engines. This dual action hints at improved genetic stability and metabolic health.

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#32

Ok that tears it, we’re going back to weekly dosing. Not ready to try 1mg a day yet but biweekly isn’t working for us. My husband and I switched some months ago to biweekly dosing from once-weekly and we aren’t feeling as good as we were. His hair is greying much faster and my “I want to run instead of walk” is much less frequent.

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#33

Interesting paper here:

Space-Earth connection: How space weather fluctuations impact epigenetic aging in an elderly men cohort from Massachusetts, USA

Conclusion: Short-term space weather fluctuations were associated with distinct epigenetic aging patterns in blood, suggesting that, as observed in astronauts, terrestrial populations may likewise show biological sensitivity to space weather variability.

Speaks for itself, but basically they found cosmic radiation like what astronauts are exposed to makes you older epigenetically, whereas solar and geomagnetic activity makes you younger. Most likely by activating DNA repair. Actually I think geomagnetic activity greatly reduces cosmic radiation and that could be having an effect too. They should give astronauts Rapa before liftoff for sure. I would add in melatonin too. I wonder what they do?

1 Like
#34

Interesting comment.

Have been taking Rapa for a couple years, every 2 weeks, 6mg with GFJ. Started 1mg per day a few months ago, I’m not a runner (have never been as I really don’t like it) but this past few weeks I have done a bit of running on my morning walk in the woods. About a week ago my wife commented that the hair on my arms did not seem to be as grey, but the hair on my head doesn’t seem to have improved :slight_smile: I have no grey hair on my arms and chest at this time.

Will be 70 too soon LoL!

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