#21

Maybe. According to the PEARL trial data, compounded rapamycin is approximately 1/3 of the serum value of the coated rapamycin. That would mean 45mg compounded translates to 15mg coated.

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#22

Thanks. I will bring that up to my doctor. btw, as a side note… I could easily put the pill in an ‘enteric’ capsule. Would that have the same effect?

#23

There are mixed reports about that, centering on the claim that many commercially available “enteric” coated shells are not in fact enteric in the sense that they pass through the stomach undissolved into the small intestine. But there are ones that supposedly do and are legit - there are threads about it somewhere on this site. In principle, rapamycin in such a legit shell should act just as an enteric coated one. That’s the theory. Who knows what the reality is. For me, I take the rapamycin from Indian pharmacies two major brands Eris/Biocon or Zydus, and I have tested my blood levels of rapamycin 50 hours after a 6mg dose and both showed up robustly, thus telling me that whatever the coating on the two Indian brands, they are absorbed by my body well. Let’s keep in mind that everyone’s absorption is slightly different, so you have to measure to know how it works for you. I take on an empty stomach, because I don’t want any confounders. YMMV.

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#24

Enteric coating or stomach acid is not the issue, it’s solubility.

#25

I have been on 14 mg/week without effect since 3 months. I thought I was at the upper range, I also measured my peak values twice at 1/2/3 hours, I got an avg result of 66 ug/l and my decay values over time (6 measurements) showed an half time of 42 hrs. Another member found 88 hrs . The most quoted value in the literature is 66 hrs. So there is a strong individual variation which is to be expected.
Did you do any measurements of the blood values at 36 mg/week ? That would be very interesting.
What symptoms improved most at 36 mg ?

#26

Here is the Preprint. Note that half the people did not finish the study for economic reasons or non-efficacy.

Rapamycin Simmaron Study 1 Preprint .pdf (7.1 MB)

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