I have a long answer, but am at a conference for a couple of days. I hope to respond to this later.
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Thank you for responding when so busy — much appreciated.
Research supporting our findings 
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Good find!
A atividade do mTORC1 regula negativamente o crescimento e a pigmentação do folículo capilar humano
A desregulação da atividade do alvo mecanístico do complexo de rapamicina 1 (mTORC1) está comumente associada ao envelhecimento, câncer e doenças genéticas, como a esclerose tuberosa (ET), uma doença multissistêmica do neurodesenvolvimento rara caracterizada por tumores benignos, convulsões e deficiência intelectual. Embora manchas de cabelo branco no couro cabeludo (poliose) sejam consideradas sinais precoces de ST, os mecanismos moleculares subjacentes e o potencial envolvimento do mTORC1 na despigmentação capilar permanecem obscuros. Aqui, usamos folículos capilares do couro cabeludo humano (HFs) saudáveis, cultivados em órgãos, para interrogar o papel do mTORC1 em um (mini) órgão humano prototípico. Os HFs cinza/branco exibem alta atividade de mTORC1, enquanto a inibição de mTORC1 pela rapamicina estimulou o crescimento e a pigmentação do HF, mesmo em HFs cinza/branco que ainda continham alguns melanócitos sobreviventes. Mecanisticamente, isso ocorreu através do aumento da produção intrafolicular do hormônio melanotrópico, α-MSH. Em contraste, o knockdown do TSC2 intrafolicular, um regulador negativo do mTORC1, reduziu significativamente a pigmentação da IC. Nossas descobertas introduzem a atividade do mTORC1 como um importante regulador negativo do crescimento e pigmentação da IC humana e sugerem que a inibição farmacológica do mTORC1 pode se tornar uma nova estratégia no tratamento da perda de cabelo e distúrbios de despigmentação.
Full Paper (open access)
https://www.embopress.org/doi/full/10.15252/embr.202256574
Bezesk
#446
“Translationally, our data strongly encourage one to next probe in a clinical trial whether topical rapamycin can significantly retard the graying process or even repigment graying/white hair, namely in younger individuals with recent onset of hair graying, and whether this indeed prolongs anagen duration in vivo.”
How do we get the money for this trial? Maybe we should tweet at Bill Ackman?
No need to wait - lets start getting some biohacker case studies going, which would help a lot in getting people interested in doing a clinical trial.
See @desertshores spray on approach:
I think I posted this before: 30cc Trancutol, 70 cc water, 10 mg rapamycin. Mix transcutol with crushed rapamycin tablets. Let sit overnight to dissolve the rapamycin. Add water, shake and filter. Put it into small spray/mister bottles. Use small mesh metal filters. Do NOT use paper filters.
Source: Rapamycin May Slow Skin Aging (Drexel U. Study) - #28 by desertshores
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@Agetron not sure what color Quercetin will turn your locks but may make more of them. Worth adding to the mixture I bet. https://pubmed.ncbi.nlm.nih.gov/37285263/
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Healthspan just tweeted that they are now selling a Rapamycin lotion for hair growth:
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I have been taking Quercetin as an oral supplement. Never thought of it as a topical.
You are getting good results with it I asdume?
Bezesk
#451
Hopefully, they will fund clinical trials.
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I take it orally too but haven’t put it in the topical. I will in my next batch. Interesting in the study they use DMSO too.
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While in Tokyo, Japan… I decided to go for a younger looking haircut… a fade. Why not?
Less hair to worry about… and I was told I look 10 years younger. Hmmm… now my look matches the extra biological age from rapamycin dosing. Rocking 65-years… ageless!
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Yes pyrilutamide looks promising
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Has anyone done work on or tried thymulin? It is a peptide apparently made in the epithelial cells of the thymus gland, and has potential for hair growth and is also used for anti inflammation (for major cases such as lupus or Lyme diseases).
Pdf of actual research from Australia:
jakexb
#456
Definitely a good haircut!
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jakexb
#457
Trying to catch up through the posts but couldn’t find this consensus: if hair growth needs mtor, is it better to pulse topical rapamycin or should it be applied every day?
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José
#458
The International Spokesperson for Rapamycin.
The most interesting man in the world!
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Actually yeah, I have been a bit of an international spokesperson.
RapAdmin should be noticing a few new members to our group from France, Germany and Japan. While lecturing on American medicine in these places, kept getting asked… whats going on… you are younger looking since pre- covid. So… I share!
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You might try both approaches - take photos, 2 months on pulsed every X days, or 2 months applied twice daily?
The most effective dose (at least for Angiofibromas) was .2% and applications twice daily… but no studies have been done on hair growth, so its all guesswork right now…
When compared with placebo, all concentrations of topical sirolimus did not differ in severe adverse events leading to withdrawal. The ranking analysis suggested topical sirolimus 0.2% as the most effective drug. In conclusion, topical sirolimus 0.05–1% are effective and safe in treating facial angiofibromas in patients with TSC, with topical sirolimus 0.2% being the most effective.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025300/
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Thanks for sharing RapAdmin. I was wondering, is there a formula one can use to work out potency? Most carrier solutions are measured in ML, while pills are in MG.
As far as dosing, in this mouse study they applied every other day. Since this can be hard to remember I would choose odd days or even days so you don’t have to remember if you applied it yesterday:
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