I refuse to calorie restrict. It just sucks. GLP1 agonists allow comfortable reduction in calories, but it doesn’t feel like a restriction.
Rapamycin is great for giving us a lot of the benefits of caloric restriction without having to do it.
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Another approach to mimicking caloric restriction…
A high-fiber diet mimics aging-related signatures of caloric restriction in mammals
Open access paper:
https://www.nature.com/articles/s41467-025-61046-z
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And yet another approach to obtaining some of the benefits of calorie restriction: intranasal insulin. After several months, I can report that IN insulin decreases appetite without any of the nausea or other negatives of GLP-1. I tried rybelsus and was so sick --and lost too much weight, too fast, and got gallstones. But with IN I have lost just a few pounds and definitely feel that I am eating less --just don’t want as much food.
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Jonas
#24
How about taking a handful of barberries with your meal? You can get them on Amazon or local Iranian stores.
It says to improve digestive health, regulate blood sugar, and potentially benefit cardiovascular health
Rapamycin (to a larger extent) and Rosuvastatin (to a smaller extent) could potentially cause glucose dysregulation in some people (it certainly does in my case). I would think that Acarbose & Metformin (on their own, or in combination with high physical activity level) would ameliorate drug-induced or generic-related Insulin Resistance / Impaired Glucose Tolerance… So the stack seems to make sense, and is supported by mouse studies
Denet
#26
Other Options? Apple Cider Vinegar? Bitter Melon? Cinnamon? chromium and vanadium? Cold Plunge? a walk after a meal?
None are as effective as metformin/berberine.
Cinnamon is interesting, but not something I rely on. I do use psyllium husk.
