While working on the evaluation to subject myself to Rapamycin for mTOR inhibition for anti-aging purposes, it comes up to my attention that muscle buildup is prevented (1) and (2).
Who is under rapamycin cannot build muscle and can only loss muscle, especially if under additional calories restrictions.
So my take is, for an healthy aging it’s required to have a proper % body fat and adeguate skeletal muscles, but to achieve the first goal calories restriction is required, but under rapamycin it’s difficult to build muscles.
Furthermore in aging 1% of lean mass is lost every year.
Anyone tested out strategies to build muscles under rapamycin?
-hackingbiology
(1) https://www.gssiweb.org/sports-science-exchange/article/sse-123-nutrition-and-the-molecular-response-to-strength-training
(2) The role of mTORC1 in the regulation of skeletal muscle mass - PMC
Hi, welcome to the site. Muscle growth inhibition is not seen in the pulsed dosing strategy that is used in longevity applications (i.e. typically we dose once per week, or longer periods of time).
I recommend you review these threads:
Rapamycin and Exercise / Muscle Growth
Note: All these, and many more common Q&As can be found here: Rapamycin Frequently Asked Questions (FAQ)
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JKPrime
#3
I have been taking 10 mg Rapamycin once a week once a week and at the same time doing 30% CR. I’m in my mid-sixties. I’m not trying to build muscles and don’t go to the gym. That said I’m able to perform one leg squat as in my twenties. Frankly speaking I have so much energy that the exercise ( walking, running etc.) is just an outlet to spend it. My body is pretty much the same as it was in my early twenties and in better shape than majority of twenty year olds. They just seem so slow, inflexible and fat, can hardly move. I wonder that perhaps eating too much including protein ( + food additives ?) is damaging them in early age? In summary, I don’t know if my condition has anything to do with taking Rapa and/or CR or is genetic; however, it appears that neither is negatively affecting me as far as I can tell.
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