Exactly… I get a little stiffness in wrist too. Pretty minor.
It is suppose to affect bone health… and bone growth… since starting over the past 3 months… I have noticed my teeth’s bite seems a bit out of alignment.
Not sure if there could be some jaw bone growth that is causing a slight change in my bite.
Bite is more to the front not on my back teeth. Just an observation.
I am doing 3 iu daily for thymus regeneration… will do for 6 more months… 9 months total.
Going to do my Gylcan testing for inflammation and methylation dna test in a few weeks. See how hgh has affected biological age.
Based on Dr. Fahy’s trials… should gain back 3 to 5 years… on top of the rapamycin benefits. Hopefully.
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LukeMV
#43
Are you noticing any changes in your physique other than better skin? Or water retention?
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Hey Luke,
Yes… great improvements on skin quality on neck, forearms… tight stomach and chest.
Gained some hard muscle (definitely the TRT and HGH combo). Biceps are firm… lifting a lot easier at gym.
Areas like valley between my pecs… was a bit boney… has filled up… fleshed out. Gained 10 pounds of solid mass… also seems to be shredding what little bit of fat is left.
Euphoria and feeling clear headed and great.
Hopefully my thymus is repairing… will do biological tests in a few more weeks. Excited to see if I improved my inflammation and methylation… which already are great.
Thinking a course of HGH is another good choice… like TRT and rapamycin.
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A few more things.
I gained probably water weight at first… went up to 201 pounds for a week. But, that leveled down to 191 to 192… currently. Have to say was fun being a 200+ big boy… even for a week. But, truth be told prefer the 192 pounds. Feels better.
So that first 2 weeks could feel the hgh acting in my heart… especially on my workout 
days. Very heavy… full feeling in the heart… by week 3 that feeling was gone.
Interestingly… the same feeling happened when I started rapamycin those first 3 weeks.That was 4 1/2 years ago. You don’t forget that feeling. Lol. Why I didn’t worry. I think my heart was repairing.
Also, took the first 9 shots alternating (left… then right) to stomach. Got hot, hard lumps… switched to my butt. Alternating cheeks. Was initially hard and hot… fevered… then stopped having any reaction. Shot and nothing. My body was adapting. Past month and a half no reaction to shots at all. Can’t tell which side got the shot.
Feeling amazing… but felt I should give a heads up on my initial body responses.
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Jjazz
#46
My interpretation of the GH data in longevity is that increased IGF1 and GH are primarily detrimental for longevity due to their negative impacts on insulin sensitivity. There may also be some additional negative impacts during development (as supported by mouse studies), but these are irrelevant unless you are an adolescent or younger.
There can also be a big positive impact from IGF1 on thymus regeneration, as shown in TRIIM and TRIIM-X. Regenerating your thymus could be hugely impactful for longevity, at least as much as rapa. In addition to restarting production of naive T-cells (important for immunity to things you weren’t exposed to as a child), TRIIM also showed a large decrease in circulating CD38+ monocytes. CD38 is one of the primary cellular degraders of NAD+. Thus, restoration of NAD+ levels could be one of the primary reasons why TRIIM showed a decrease in epigenetic age.
So, how do you put it all together? You do what TRIIM did. Take GH or a secretagogue to boost IGF1 levels and regrow your thymus. This takes about a year. Concurrently take metformin/DHEA to mitigate the negative effects on insulin sensitivity. This can help you get the benefits without the downsides. At the end of the year, stop, and work on improving your insulin sensitivity, activating autophagy, etc. Get back to other longevity interventions.
Also, if you are trying to regrow your thymus, don’t take rapa during TRIIM or a TRIIM-like protocol. Rapamycin has potent effects on thymocytes that work against the proliferative effects you are aiming for with TRIIM. You can take rapa when you are done with the 12 month protocol.
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Hey Jon… thanks for your additional insights on Thymus rejuvenation. My TRIIM-like protocol. In several YouTube videos, Dr. Fahy gives pretty easy instructions on what to do. I am under the care of my personal physician.
And yes, as a precaution - I have been taking DHEA with my nightly shot. No insulin issues finishing 3 months of dosing.
Taking two 50 mg pills.
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Jjazz
#48
Are you measuring your IGF1 levels? What is your target?
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Hey Jon my current eGFR is 48 and has been there the past year.
Looking to see if HGH pushes that score up to 90. My goal.
Here’s a more detailed breakdown:
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Normal eGFR: 90 mL/min/1.73 m2 or higher.
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Early-stage kidney disease: eGFR of 60-89.
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Mild to moderate kidney disease: eGFR of 45-59.
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Moderate to severe kidney disease: eGFR of 30-44.
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Severe kidney damage: eGFR of 15-29.
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Kidney failure: eGFR of 15 or less.
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Jjazz
#50
TRIIM did see increases in eGFR of about 10%, starting at a higher baseline though. Hopefully you see some improvements there.
Have you looked into SGLT2 inhibitors? They can also have a nice stabilizing effect on kidney function, with documented results in many more patients than TRIIM.
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I have not… heard lots on this site.
Need to do some research. Thanks.
Neo
#52
It’s interesting
Such an approach could perhaps also be combined with focus on reaching peak strength and muscle size (if the idea that there is muscle memory is correct) and perhaps also optimize for bone density etc
So similar to perhaps avoiding rapa (and fasting, CR and protein restriction?) that year should perhaps also focus more on resistance training and less on cardio…
Any thoughts hivemind?
—
Any thoughts on at what age to do the first thymus regeneration and then how often to do it?
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Hi! Do you know, that eGFR should be corrected for height and weight, particularly in individuals with large or small body surface areas (BSA). The standard eGFR calculation often uses a BSA of 1.73 m2, which may not be accurate for individuals significantly different in size and weight. Or you have exactly reference height/weight… just FYi
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Jjazz
#54
That’s a tough one. TRIIM is accepting patients 40-80 years old, so that must be Fahy’s best guess of who will benefit. Admitting people that won’t show a measurable benefit would be very poor strategy for a trial like this.
Younger patients will benefit from having more thymic mass to begin with, likely leading to a larger growth response. Older patients are likely experiencing more consequences from immune decline, and are thus the most likely to experience related benefits.
I’m 39 and doing a TRIIM-like protocol now.
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eGFR depends on the reliability of the original biomarkers. If you use creatinine and go to the gym on the days before the blood draw then you can improve eGFR by not going to the gym, but that does not mean you have better kidney function.
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Something that is very obvious since starting HGH about 3-months ago is significant and loud joint popping in my elbows. Multiple times a day.
My elbows show no pain or restrictive movement from this - if anything, I am more flexible and absolutely no pain issues. My belief is this change of more frequent popping is an indicator of healthy and a good amount of synovial fluid as a result of HGH effect on one’s cartlidge.
FROM AI:
HGH is known to cause the liver to increase production of Insulin-like growth factor-1 (IGF-1). Circulating and locally produced IGF-1 is known to stimulate DNA synthesis, cell replication, and proteoglycan and glycosaminoglycan synthesis in articular chondrocytes. IGF-1 and HGH have both been shown to stimulate the growth and repair of adult articular cartilage. One reason for this cartilage growth can be that some cartilage cells have HGH receptors.
The most common sources of that telltale pop/crack are synovial joints. Dr. Bang explains that in a synovial joint, the two bones are connected by a capsule or membrane. Inside that capsule is synovial fluid. That fluid also contains oxygen, nitrogen and carbon dioxide. A popping joint occurs as stretches the capsule - the escaping gases in the stretch release and pop. It makes that cracking sound because you’re creating a negative pressure inside of that synovial joint space.
Synovial fluid is like motor oil for our joints, he continues. It provides lots of lubrication, so things are slick and move nicely.
My take is, that synovial fluid is a sign of healthy lubricant for joints. Something we lose with age. More popping is a sign of returned - good synovial fluid health.
Now this too from AI: Synovial fluid generally decreases with age, leading to stiffer and less flexible joints. This decrease in fluid, combined with thinning cartilage and shortening ligaments, can make joints feel less mobile and cause pain. And obviously - less fluid- less gas escaping - less popping.
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