#41

Could a simple calculation be then that a vaccination is preferred if the vaccine that is taken will prevent at least (1) infection within the immune period? If the efficacy is 50% for example, then it would be (2) infections. Since the pathogen is worse than the vaccine, maybe 40% for a young person it could be 0.6 and 1.2 infections instead, maybe. It depends how solid the Alzheimer’s data is for example as well. What would your numbers be?

How do you stand with regards to Valaciclovir, an antiviral, taken as a prophylactic to prevent infection from the herpesvirus family (Shingles - Alzheimers, EBV - Multiple sclerosis, etc)?

#42

Very interesting:

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Microbes, including fungi, routinely infect the brain, but specific immune pathways are undefined. Wu et al. show that Candida albicans activates microglia through two mechanisms involving the production of amyloid b-like peptides that signal through TLR4 and candidalysin that activates CD11b, together promoting clearance of albicans from the brain

https://www.cell.com/cell-reports/pdf/S2211-1247(23)01252-4.pdf

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#43

Michael Lustgarten has a video on Rapamycin and Candida that shows huge effect on Rapamycin and Candida infections in the brain, basically if you use Rapamycin you will have very little Candida growth and almost none in the blood stream witch equals much lower incidences of Alzheimers. Coincidence, I don’t think so.

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#44

Can you please post the video?

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#45

I don’t have it, I cam across it on youtube a couple of months ago. But it is not like his typical videos, it’s a stand out. I will try to find it later today.

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#46

Here is the video:

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#47

More: Google Scholar

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#48

Won’t an aspect like the reduced risk of Alzheimer from some vaccines, if this is causal, be likely to more then offset the effect of reduced immunological space?

#50

“We then show that receiving the herpes zoster vaccine reduced the probability of a new dementia diagnosis over a follow-up period of seven years by 3.5 percentage points (95% CI: 0.6 – 7.1, p=0.019), corresponding to a 19.9% relative reduction in the occurrence of dementia.”

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#51

In many people yes, but in others no. It depends on your relative risk of Alzheimer’s vs your risk of respiratory infections like pneumonia.

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#52

Olafurpall:

Besides probably causing a reduction in Alzheimer, the vaccinations guard against the diseases they are meant for. Can’t the combined effect be likely to yield a net benefit to most people?

#53

Yes, in most people it probably is a net benefit.

#54

Any opinion on taking an antiviral as well?
Because I have an APOE4 allele, about 3 x causal increase in risk for Alzheimer’s - it is very worth it to me with vaccines.

#55

Antivirals could be of benefit and they would not cause a reduction in immunological space. They might have some other side effects though. I can’t say I have looked into them much at all so I can’t give a good opinion on them.

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#56

The BCG (Bacillus Calmette-Guérin) vaccine was developed against Tuberculosis over 100 years ago, but it is known to protect against other infectious diseases as well. A Phase III randomized clinical trial from Harvard shows that multiple doses of the BCG vaccine protected adults with Type I diabetes from COVID infections better than the initial mRNA COVID vaccines. It also protected this group against other infectious diseases. The BCG vaccine worked against COVID variants Delta and Omicron in this study.

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Vaccines for longevity
#57

Apparently even freeze dried BCG has cold storage requirements. Though I see some conflicting evidence of this online.

This study indicates it does seem to lose potency, but should still be effective up to 2 months at room temperature.

https://www.sciencedirect.com/science/article/abs/pii/S0007097163800078

Other sources from googling all state it must be kept in cold storage.

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An anti-aging vaccine: BCG turns back the clock on remyelination failure