#406

USA has many FDA hoops to jump through before market approval and commercialisation. It’s discussed a bit here:

You could always reach out to the supplier and ask for infobon the source. But the site specifically mentions it’s the trademarked brand so presumably they’re using Sederma’s Silverfree unless they’re falsely advertising.

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#407

Hi dhanny. Have they said if they are doing clinical trials to verify safety and efficacy at this time? This product looks quite promising.

#408

Do you mean FDA trials for Greyverse? Not that I’m aware of. But you can still buy products that contain it in the US they’re just not FDA approved.

#409

I’m pretty sure it won’t work. Looks like only cancer meds or immunosuppressants might help. I think topical BMS-202 is our best bet.

#410

What are the potential side effects of using BMS-202?

#411

This is an anti-cancer drug, so the side effect is reversal of grey hair. This is the writeup that got people excited about it: Hair Repigmentation During Immunotherapy

In cancer treatment I think BMS-202 is being investigated as an anti-cancer drug taken orally. I think people are planning to use it as a topical agent to see if we get the same results as oral, but without the systemic effects. I don’t think we have enough information to know if there are other “side effects”, but I’m thinking that as a topical drug the side effect risk seems pretty low (but I’m not a dermatologist).

See discussion and links here: Group Buy for Hair Loss, Gray Hair Reversal, and Anti-Aging

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#412

@Bezesk There are a few links to studies either in this thread or on the Rapamycin for Hair Growth and Hair Pigmentation thread that seem to support the efficacy of a-MSH’s as a topical agent to help reverse gray hair. But the success stories seem far and few between so I agree that immunosuppresants are likely the best way forward. There just isn’t data/ info on their application specifically for hair repigmentation with control groups to support their safety at this point. Hurry up Eirion!

#413

I’ve been using a hair lotion with palmitoyl tetrapeptide-20 and Melitane for years, and it’s not doing the trick. And it seems like the guys trying out topical rapamycin aren’t getting their full hair color back. As for TM5614, it helped someone get some color back, but it wasn’t a game-changer. I want my hair color back now, not in decades when new treatments might be available. So I’ll give BMS-202 a shot.

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#414

@Bezesk - love it. Maybe a combination of treatments? Pease document your experience.

#415

Actually, to be clear, from what I’ve read on and understand from this thread and the other “hair growth/color” threads in this forum:

  1. many people here have tried simple topical Rapamycin to regrow hair and to restore hair color, and it appears to mainly be a dud (I mean ONLY Rapamycin topically in some medium such as DMSO).

  2. And people who are taking Rapamycin orally don’t see meaningful hair growth or color changes unless they are taking organ-transplant concentrations of rapa.

  3. But when they combine it with minoxidil, finasteride, and other compounds which are well-documented to regrow hair their hair regrows (with some color), and many studies have shown that this happens without rapa, so I assume the rapa might benefit skin quality/etc but may not really be doing much for hair regrowth nor color. (I’m sure @Agetron and @desertshores may have better insight)

This isnt an n=1: it is only a voracious “literature reading” of the posts on this and other threads. Is this correct?

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#416

What is taking Eirion therapeutics so long to start clinical trials? Funding issues? They have a patent from a few years back stating that they have already tested out their ET-02 on human subjects and it worked in reversing grey hair and very well in hair growth. So as it sounds like a gold mine potentially cure for both hair loss and grey hair, what is taking so long for them to bring it to market or even start a phase 1 trial :confused:

#417

ET-02 (TM5441) and TM5614 are both readily available and fairly safe. TM5614 is just a stronger version.

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#418

Will you go topical or oral?

#419

I’m definitely taking it orally.

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#420

Another study on Greyverse if anyone is interested.
Efficacy and safety of hair serum containing Greyverse, EUK 134 and Amisol trio in premature greying of hair | International Journal of Research in Medical Sciences

#421

Found a source in USA. New product

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#422

I’m only 1/4 through this thread, but I searched for “Amazon” and didn’t find mention of the Amazon Clinic as a prescription source of low-dose oral Minoxidil. Last week, I did a text telehealth visit with a random doctor from the alpha clinic for $29. After uploading photos of my hair and explaining my symptoms (diffuse thinning), she wrote prescriptions for 1 year of 1mg finasteride (not sure I’ll take it), and 6 months of 2.5mg oral minoxidil. My local pharmacy with GoodRx was cheaper than Amazon’s pharmacy, so I had the meds sent there. Of the 4 available clinics for my state, only the alpha clinic will prescribe oral minoxidil. Forgive me if this was already posted somewhere and I missed it in my search.

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#423

This is the grean tea extract that acts a hair dye? Sorry I haven’t been on for months, and there are so many messages in this thread…

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#424

The capsule green tea EGCG mixed in equal amounts… with the Reveratrol when combined makes a color of a reddish brown with blonde hint. The DMSO saturates into the hair shaft… makes it permanent… doesn’t wipe off.

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Took this pic just now. A nice healthy color… hair feels healthier. Pardon the messy morning hair… it is 6 am… flying out of Milano, Italy. Lol

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#425

Lol. Thanks, good to know :grin:

For now, my aim is the maintain my own color or reverse the partial graying “endogenously”.

1 Like