Radiata
#441
Tyrosine supplementation may also help
Looks like there are potential interactions between Tyrosine and mTOR:
https://www.nature.com/articles/cr2015134
3 Likes
scta123
#442
Ingredients:
Aqua, Isopropyl alcohol, Glycerine, Biotin, Ammonium Chloride, Inositol, Ammonium Acetate, Palmitic Acid, Polysorbate 20, Tyrosine, Burdock Root Extract - Articum Lappa, Gallic Acid, Sulphur, Horsetail Extract, Parfum.
I checked the ingredients and marked the possible active ingredients. Since Ammonium Acetate is usually used in less than 1% in hair and Ammonium Chloride is used in 1% concentration in hair leave in products this gives some idea about composition.
Anyway, I ordered first bottle on promotion, 15% off 
, will report back.
5 Likes
sev
#443
I can’t tell you how it works because I honestly don’t understand it. But it doesn´t replace the melanin from the roots because if you have gray hair and you use it for a few days the greys will disappear, but it isn´t that the hair grows without gray hair but rather the hair that was white a few days before is now your original color.
One way to test it is on the beard, if someone has gray hair and uses it and then shaves, when it comes back they should no longer have gray hair, but I doubt that is the case.
2 Likes
cl-user
#444
Here is another l-tyrosine based grey hair restoration product for the DIY minded HydroSal® Hair Color Restoration
L-tyrosine is a non-essential amino acid that occurs naturally in your body and produces melanin, the pigment that determines skin and hair color. L-tyrosine taken as a supplement may help prevent graying and return hair to its original color.
Research shows that gray hair is caused by a buildup of hydrogen peroxide in the hair shaft, a natural occurrence in aging. When the hydrogen peroxide accumulates, it damages the melanin responsible for giving hair its color. The higher levels of hydrogen peroxide that occur as a result of lower levels of catalase reduce levels of tyrosine as well, inhibiting its ability to produce melanin.
Hair Anti-Aging Conditioner Formula
| Ingredients |
(W/W %) |
| HydroSal® Hair Color Restoration |
2.00 |
| HydroSal® Hemp |
1.00 |
| Oryza Sativa (Rice) Extract |
2.00 |
| Glycerin |
3.00 |
| Behentrimonium Chloride |
4.00 |
| Cetearyl Alcohol |
1.50 |
| Glyceryl Stearate |
0.50 |
| Cocos Nucifera (Coconut) Oil |
1.00 |
| Squalane |
3.00 |
| Argania Spinosa Kernel Oil |
3.00 |
| Helianthus Annuus (Sunflower) Seed Oil (and) Rosmarinus Officinalis Extract |
0.50 |
| Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol 1.00 |
1.00 |
| Fragrance 0.20 |
0.20 |
| Water (Aqua) 77.50 |
77.50 |
That one on amazon has a pretty similar composition to GR7: ANTI GRAY HAIR FOR MEN AND WOMEN - tyrosine natural - gray hair color
4 Likes
Paul_2.0
#445
It’s just replacing the pigment on the hair follicle. It’s not permanent but it’s flooding the hair-shaft with tyrosine, which is what is present in a hair with a functional hair bulb. It’s a dye in the sense that it is mimicking the contents of a healthy hair.
2 Likes
Thorin
#446
Certain types of anabolic steroids are DHT-based. This type of steroid will increase muscle mass. It will also cause balding in anyone with a propensity towards male pattern baldness.
Anyway, I don’t think we can say it has no role in adult males. Increasing the levels (together with strength training) does result in increased muscle mass. It is not an inert substance.
I have no idea what it would do in adult women, but … probably not a good idea!
1 Like
Thorin
#447
The paper says: “The 20-week study of 102 healthy men examined the effects of high-dose (2.5 mg per day) dutasteride (a 5α-reductase inhibitor) and testosterone enanthate compared with placebo and testosterone enanthate. […]. Each arm was also subdivided into four dosage branches based on the testosterone dose given (50–600 mg per week).”
600 mg per week of testosterone…!!! In a medical study. Wow. That is a dose that a steroid using body builder would use while on cycle. Who would expect muscle mass reduction in that scenario? Even at 50 mg per week, probably most men won’t see any reduction in muscle mass over 20 weeks.
I would not expect suppressing DHT for 20 weeks while administering testosterone would reduce muscle mass. I would anticipate an increase in muscle mass at the higher dose, and no observable effect in such a short period in the lower dose.
3 Likes
Agetron
#448
Sounds good. I do like my tonic.
I went off my hooch tonic for 5 months… and loss my gains… fine thicker hair. Went back on 3 weeks… and yep…it does grow hair and it gives me a color that’s natural to my own color.
1 Like
I guess it would make sense that they could develop it to work in that way. I think also of note is that it’s developed by Northwestern University who have done a lot of work with PAI-1. So it may become a research focus area for them. Good find @AndyR00.
3 Likes
DrT
#450
I wonder what form the sulphur is in?
(Some users have commented on the smell.)
Elemental?
H2S?
Ludovic
#451
I use the product Dutasteride AB. AB stands for Aurobindo, the pharma company. It’s a 0,5 mg soft capsule which a gel like liquid
2 Likes
Ludovic
#452
Thanks for this info. I have my 23andme data and will try if I can do something with this first. What advice did they give you based on your genes?
Exogenous DHT is a different story than the DHT we produce ourselves.
scta123
#454
Would you care to colorize this statement?
1 Like
sol
#455
Tyrosine is easy to come by. As is NA-L-Tyrosine.
If that’s the active ingredient, why not just DIY it? Combine with transcutol, maybe? Some ointment/water carrier, and apply? Would be cheap.
ANyone think this might work? Anyone tried it?
1 Like
Bicep
#456
Don’t forget Burdock and horsetail. Both weeds here, but possibly important to the formula.
1 Like
It may just be the lighting in the photos, but it looks more like a richer brown on the right compared to the left. Did you notice it change the overall colour of your hair, or just the gray hairs and the rest was unaffected? Also, did you notice any staining during application?
There’s no staining. It’s a clear liquid. It may just be the light, but they do say that the when the color begins to return to the follicle it starts out blonde and will get darker. This was only about two weeks in and it’s recommended to do it for three. Honestly, though I can’t tell the difference.
3 Likes
sol
#459
Quoting myself here, to try to get additional comments and perspectives. Given how expensive hair and skin care products are, I’m interested in DIYing it, if tyrosine has some possible positive effect (on skin or hair) and is safe to use topically. (I already take it as a supplement.)
But I was unable to find research indicating that tyrosine (L or D) helps with hair color. I admit that some of the NIH papers I found are a bit over my head. (Attempted humor. Still waking up.)
Anyone?
