It’s so wonderful to hear your old girl is doing great! My old pit-boxer boy, Flapjack (not the one with the sarcoma), is almost 17, and I can really tell the difference when he’s not on Rapamycin. He’s about 75 lbs, going blind, and a bit wobbly, but he still goes on 45-minute walks every day and 2-hour walks on weekends. We also only feed once a day and low carb. My cancer patient eats different proteins and we try hard to keep it low carb as well. He became very picky after he had a seizure-like event on Mother’s Day. We now believe it may have been due to the pheochromocytoma condition, although I didn’t do the $600 test to confirm the diagnosis. About the palpable tumor, have you tried a stasis breaker? My 17-year-old is covered in lipomas, but he also has some huge hard neoplasms that I never had the vet check. The vet said if they were malignant, he would most likely be dead by now. They started to soften with a Chinese herb extract called “Dissolve Mass”. They now hang like old sacks. My husband jokes that he needs a bra. Poor kid, lol. I purchased this extract from bestchinesemedicine.com. Unfortunately, it did nothing for the lipomas, but the neoplasms were huge. The largest one was just over 4" in diameter. I don’t know if they will disappear completely, but the largest one is at least half the size now. I still give him the Dissolve Mass to him daily.
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KarlT
#22
How’d you come up with this dosage? Thanks.
Dr. Kevin Toman. Longevity vet in California. We do zoom consultations with him off and on.
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All drug dosages were recommendations from different vets. The supplements I figure out the old woowoo way: applied kinesiology. Lol. Most docs, other than chiropractors and naturopaths don’t like this process, but it has worked for us.
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Beth
#25
@Mdecrasto and anyone
All of you have me wondering about giving my cats Rapamycin, but I would not know about dosing or if there are any contraindications.
I realize no one ‘knows’ but let me run their stats by you incase you have heard one way or another.
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Dewey has a heart murmur, but otherwise healthy, on Solensia arthritis medicine
15 1/2 yo
Aprox 14 lbs
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Sylvester has CKD, gets subq fluids, is on an acid blocker (famotadine), porus one, and is about to switch from palladia to Imatinib (gleevec) for her mast cell tumor, aprox 1 seizures per mont or two, on solensia for arthritis
16 1/2 yo
13 1/4 lbs
(She sounds like a hot mess but she is so happy and acts like she is in better health than she was 2 years ago!)
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Scooter has CKD and gets subq fluids and has a heart murmur.
17 1/2 yo
8.25 lbs
Dr. Kevin Toman can help. He’s a longevity vet in CA and does phone consultations. He gave me the rapa dosage, and the vet oncologist gave me the fenben, Ivermectin, and Metformin dosages. As far as CKD goes, the Five Leaf Pet Protocol is amazing, and if you contact them, they will let you know their experience with felines, if any. I added Azovast and a phosphate binder to it. Rapa may help the heart, BUT my 64lbs and 75lbs boys did well with high dose CoQ10, 600mg daily for 2 mos, and now, 600mg alternating with methylene blue. I only give 2mg of pure methylene blue, but I’m always concerned about serotonin syndrome, so I try to avoid multiple serotonergic meds/supplements on the same day. Be careful because some vets do not know how some drugs work. My vet-oncologist prescribed a very high dose of methylene blue for my boy with hypertension, so I lowered it on my own because MB can cause temporary hypertension. When I asked him, he said he had to double check with his team. I’m not sure he knew, and that’s okay. Dr. Kevin may know about the CoQ10 for cats as well, but not sure. Best of luck!
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Ludovic
#27
I have been searching for a human fenben / ivermectin protocol from Dr. William Makis, but it seems to be hard to find. ChatGPT refers me to this video…
Beth
#28
Thank you so much! I’ll look up five leaf.
I randomly sent my IM vet an article incase she was curious, but it turns out she has some dogs on rapa, knows all about the dog aging project, and the work going on at Stanford (I’m learning there is nothing she doesn’t know!)
The shared this study from last year regarding cats on rapa
The cats started on DR rapa .5mg and then progressed to 1mg.
I have to read through this study a few times to have it all sink in, but assuming I want to start, how do people handle giving split pills? I can order a delayed release capsule and put it in there, or any other methods?
javma-javma.23.04.0187 (1) Rapamycin HCM.pdf (885.8 KB)
I think they have pill pockets for cats. My small girls take split pills in pill pockets. I started them in very small doses 1.5mg per week in 3 dosages, Mon, Wed, Fri. My girls are 13 and 15lbs now. Holidays weight gain. Lol.
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The average human ivermectin dose is 1mg/kilo/day. This is from Dr. Makis. I’m trying to attach a screenshot of his email but don’t know how. Some folks take more. I’m also trying to find the fenben info. Tippens protocol starts at 222mg and goes up to 444mg, but my old dog started at 15ml per day OR 1500mg. It’s high, but it worked fast and it didn’t affect his liver. Is it possible to attach a pic here?
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Beth
#31
Oh thank you! I put their pills inside empty capsules and then hide in treats. (They don’t like pill pocket, sigh).
I thought I read something about not cutting a rapa, but if you do it, I’ll assume it’s ok.
What is the reason behind dosing 3x per week, when we, as humans, tend to take it weekly?
I had no other way to admister to my girls because the 1mg tablet is the smallest dosage I could find. I checked for warnings on the bottles, and there’s nothing that mentions not cutting it, so I do. I could be wrong. Dr. K did recommend putting the tablets in acid-resistant capsules, which I do for my big boys, but not the little girls. I need to get smaller ones for them.
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Dr. Kevin follows Dr. Kaeberlein’s recommendations, I believe. Dr. K is the one who recommended 3mg 3x week for the dogs. I was taking 1mg/week myself, and now 3mg. My boys take 6mg more than I do per week. Flapjack is almost 17, which isn’t bad for a boxer-pit, so I keep him on this dosage.
Jay
#35
From my point of view reporting on things that work is always welcome. You have a complex list of things you’re doing, but the Fenbendazole is very recognizable from the Joe Tippen’s story about how he put his lung cancer into remission, for years at this point. He has a protocol he continues to use that includes Fenbendazole as a key ingredient. It’s an interesting read at this location: The Blog – Get Busy Living
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Beth
#36
It’s interesting to learn Kaeberlein is doing 3x per week dosing for dogs. He takes it weekly, and so did the cats in the study. There is obviously a good reason he’s doing it differently, so I’d love to learn his thought process. Maybe there is some calculation relating to the lifespan of a dog.
Funny they take more than you do. I take 6mg per week.
Davin8r
#37
His first smaller study was 3x weekly, but the Dog Aging Project is a once weekly (0.15mg/kg I think) protocol.
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Maybe Dr. Kevin can answer that question for you. I think he follows the Dog Aging Project. Again, I don’t know for sure, but my old boy has been taking it for years and does really well on this dosage and frequency.
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Beth
#39
I just gave all 3 cats rapa!
@Davin8r, I’m glad you included Kaeberlein’s .15mg/kg. I do remember he said he went on the low side to be extra safe.
The .15mg is lower than they used in the cat study, and because it was the first time, I just had all 3 cats split 1mg to be extra safe… that, and I’m up to my eyeballs in cat care and can’t deal with any side effects, even if small!
And @Mdecrasto, I’ll order some delayed release capsules, so thanks for sharing about the acid resistant capsules. It makes perfect sense because cats can eat raw because their stomachs are so acidic. I’ll choose DR because that is what they used in the cat study. If I didn’t have my vet, who I cherish, I’d reach out to Dr Kevin.
Also, for anyone giving cats pills, I recently discovered a new method. I use a Churu tube of goop, I then stick the capsule in the hole on the top, and I have them eating the goop out of the tube as I squeeze the product out of the tube for them… and with it, they eat the capsule.
This is what I found on Dr. K’s website about the dosage and frequency differences:
