#321

A pity she didnt say how much she is taking😅

2 Likes
#322

The mice/monkey trials indicate 3-6g are sufficient and 6g is the maximum established daily dose.

#323

“Patients should not go out and start consuming taurine in high levels to help with long COVID,”

6 Likes
#324

Taurine virtually poses no health risk at moderate doses, is very cheap and potentially has a lot of benefits. There’s no reason not to supplement with it.

8 Likes
#325

I think the entire energy drink industry can substitute for a RCT to prove the safety profile of taurine.

Most energy drinks have anywhere from 20 mg up to 2,000 mg of taurine in a 16-ounce beverage.

So at 2g per drink, with some people drinking multiple daily, I have never heard of any adverse taurine outcomes. It’s safe.

7 Likes
#326

I recall Huberman saying he had a bad reaction to taurine so maybe it’s individual.

2 Likes
#327

True. We all have our own unique biologies. I have had adverse reactions to “safe” statins, beta-alanine, and others. What may be good for you may be toxic to others and vice versa.

3 Likes
#328

I’ve been taking 8g per day for a while now and no complaints!

4 Likes
#329
1 Like
#330

Since cysteine is a precursor to taurine, I wonder if its availability support the body’s production of taurine?

Taurine is synthesized from cysteine and methionine, this makes me wonder:

  • If supplementation with acetyl-cysteine will increase the levels of Taurine in the body?
  • If supplementation with acetyl-cysteine, in a meaningful way, will use up some of the methionine and decrease the levels of methionine in the body?

The body’s capacity to convert cysteine to taurine might depend on enzymes involved in this conversion process, so the only way to figure out what is the case, is research. I have not found much research about this. Does anybody know about research in humans, related to these questions?

1 Like
#331

"Cysteine sulfinic acid decarboxylase, a rate-limiting enzyme for taurine biosynthesis, has been cloned and sequenced in the mouse, rat and human. "

"Another key enzyme for cysteine metabolism, cysteine dioxygenase (CDO), has also been cloned from rat liver. CDO has a critical role in determining the flux of cysteine between cysteine catabolism/taurine synthesis and glutathione synthesis. "

I really wonder what impact cysteine supplementation has on the synthesis of Taurine?

Could it be a possible N(1) experiment ? @ConquerAging

3 Likes
#332

Iollo (discusses where on this forum) gives you a measurement of both Taurine levels and Methionine levels (so you could N=1 test is out)

1 Like
#333

If you think about it, that would make no sense. Met is used to make Cys; if you provide some Cys, there’s less need to convert Met to Cys, so if anything it should increase the level of Met in the body.

#334

Just an idea.

Taurine is synthesized from cysteine and methionine.

If supplementation with acetyl-cysteine will increase the production if taurine. Then the body would use more methionine?

1 Like
#335

I take 3g throught the day … 1g with my morning black coffee, second gram with my second mid day coffee and last gram before I go to sleep.

Love Taurine … most beneficial supplement I ever took.

So many life improving changes.

4 Likes
#336

Right. Again, If you think about it, that would make no sense. Met is used to make Cys; if you provide some Cys, there’s less need to convert Met to Cys (to make Tau or for any other purpose), so if anything it should increase the level of Met in the body.

Company X uses steel to make ballbearings, and uses some of those ballbearings to make skateboard wheels. Suddenly it gets a free supply of third-party ballbearings. Then the company would use more steel? No, the company would use less steel, and start accumulating a stockpile.

1 Like
#337

What have you observed?

#338

I agree. you bring up a very possible scenario.

The net result from extra cysteine would depend on:

  • The hypothically increased amount of methionine that is used to produce more taurine when there is excess cysteine in the body.

  • And the amount methionine that is spared because there is no need for it, in the production of cysteine (Since there is already enough cysteine).

Without knowing the feedback loops and the rate limiting enzymatic steps in the conversion processes, it is hard to estimate what the net result will be. But your reasoning make me agree on, that your scenario is more likely than mine.

1 Like
#339

I wonder if you perhaps mistakenly think that the body uses both Met and Cys as direct precursors to make Tau, so more Cys might increase Tau production and require more Met to do it.

This is not correct: the only way that Met is involved in Tau synthesis is by being converted to Cys, which is then oxidized and through several sequential steps converted to Tau. Therefore increased supply of Cys reduces the need for Met metabolism for this and other purposes. See my steel and ballbearings analogy above.

#340

Thank you for taking the time to clarify the above. So the experiment that could be interesting to do, is to see if an amount of 6-7 gr extra cysteine (that some of us here are taking) raise the level of met?