If i am right that many senescent cells are those which have failed to differentiate from stem cells because of a failure of gene expression, then improving gene expression will make them function. My experiments point to this being true. One route to this is through HDAC inhibition through molecules like fisetin, curcumin and pterostilbene. It also takes CRP down as a biomarker.
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Jay
#113
Terri, That is an interesting method. I wonder why Dr. Green chose that method? I’ve been doing a senolytic therapy method of 100 mg Dasatinib + 1 gram of Quercetin three days in a row every three months. It looks like I may have to research this topic again.
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Jonas
#114
does follow-up have to be in person?
Senolytics, which remove old zombie cells, prove safe and beneficial in non-human primates. Another step closer
Key Paper: http://tinyurl.com/34zuv4vw
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Terri
#116
No, we spoke over the telephone. He puts a lot of stock in one’s HOMA-IR, so I made sure to have bloodwork prior to our call.
SUMMARY: It’s better and more effective to prevent senescent cells using taurine or rapamycin than to remove them later using senolytics. But, you could probably do both (taurine + senolytics) and the benefits would probably stack. Probably Rapa and Taurine as well.
If senolytics are good, then taurine is even better.
I liked the study from the video below where they tested mice for senescent cells. They had three groups - control, senolytic, and taurine dosed. The control group had a normal senescent cell load (no surprise). The senolytic-treated group had fewer senescent cells and a longer lifespan (~10% longer). The surprise was the taurine-dosed mice had fewer senescent cells than either of the other two groups along with a much longer lifespan than the others (~37% longer!!!).
Reference Video (time 5:50):
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You’ve sent me down the rabbit hole. Very quick, dirty googling tells me taurine supplementation is pretty good for people before considering the impact on senescent cells.
Taurine and the renal system - PMC.
The beneficial effects of taurine in alleviating fatty liver disease - ScienceDirect.
Taurine and inflammatory diseases - PubMed.
What I heard in your video link is doses of 3 to 6 mg daily.
Now to find out the drawbacks.
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In addition, the Columbia U study was suggesting 3 to 6 g of Taurine daily. That also showed improved life expectancy from Taurine supplements. Taurine is inexpensive and effective.
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I’m down to my last “hit and run” dose of fisetin. Taurine in the future.
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CTStan
#121
https://www.science.org/doi/abs/10.1126/science.abn9257
The authors concluded: “Taurine abundance decreases during aging. A reversal of this decline through taurine supplementation increases health span and life span in mice and worms and health span in monkeys.”
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Since mice, monkeys and humans all show a decreased level of taurine in old age (20% of youthful levels) AND supplementation of taurine in mice and monkeys extends lifespan and healthspan AND supplementation of taurine in old humans has shown positive effects on healthspan, I think it’s safe to make the jump to assume taurine will extend the lifespan of humans significantly. Plus it may prevent cells from becoming senescent.
Taurine is inexpensive and doesn’t have any significant side effects. It’s a no-brainer addition to my supplement stack.
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Are you going to take all of it in one dose or spread it throughout the day?
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I dump the whole dose in my morning coffee along with Glycine and Collagen. I heard Taurine may interfere with sleep so I want to take it as early as possible.
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How big is that coffee? I usually dose glycine powder (9 g) at night mixed in water with flavored magnesium citrate powder and use that to wash down my collagen pills (and the rest of my evening stack). Maybe it is cold liquid vs hot liquid, but I have to stir a lot. It’s worse when I add creatine (5 g) to the mix.
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And while we’re at it, which taurine powder are you using?
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I use just a normal mug of hot coffee. Most of the powders dissolve well although I do add some hot water afterwards to get more of the powder that doesn’t dissolve.
I use this brand for taurine
https://www.amazon.com/BulkSupplements-Taurine-Powder-500-grams/dp/B00ENSLW7U/
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I like what I see on this… I just ordered 2.2 pounds. Thanks for all the research and link … all at one’s fingertips. I am done with Fisetin… used last capsule last night. Not reordering.
Why the members on this site rock. Honest reliable feedback.
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50mg was the dose that Dr. Garcia in Las Vegas (recently retired) put me on.
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Senescent cells are typically associated with aging and health problems, but a new study adds to the growing evidence that “zombie” cells can actually be beneficial.
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I think a lot of senescent cells are stuck in differentiation
