#169

My (N1) experience with high doses of vitamin K is that if I take K1,K2M4 I get anger issues. (Like the one you show).

I have tried it several times. But K2M7 alone up to 150 mcg is ok. It is weird and unexplained (I have the same issues with Ginko Biloba).

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#170

Its a strange mixture. MK7 improves ATP production by providing an extra electron transport for the ETC. AFAIK MK4 does not have this effect (although you are probably taking a lot more MK4 and K1). All the Ks have a quinone element, however, and I wonder if they all have some effect on ATP.

My own experience (and I don’t deliberately take K1) is that MK7 in even small quantities had the effect of disrupting sleep by boosting ATP production.

I also take MK9 (in a sort of “why not” sense). I may drop the MK9, however, as I am not to clear on why to use it.

Ginko Biloba AFAIK is a Yang Qi supplement which potentially activates AMPK. Hence it should also give a boost to ATP if possibly through autophagy.

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#171

My research says that menaquinone-4 (MK-4) has a relatively short half-life (about 36 hours) and menaquinone-7 (MK-7) lasts much longer. I take MK4 daily, and MK7 every week.

I’m not going to track down that research just now, but here’s one:

The effects of long chain MK-n such as MK-7 on normal blood coagulation is greater and longer lasting than vitamin K1 and MK-4

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#172

My personal experience with MK-7 is that it disrupts my sleep for the night after I take it, but then that problem fades.

Currently I take MK-7 when I am trying to exogenously increase ATP production. I am doing that for a four day sequence during which I am also taking Rapamycin at the moment. (I took Rapamycin in the morning today)

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#173

I found this today. Looks relevant, with a focus on the ill effects of COVID on brain cells.

https://www.reddit.com/r/longevity/comments/17vsjl7/senolytic_therapy_alleviates_physiological_human/

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#174

A post was split to a new topic: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

#175

I found the commentary on Fisetin and more generally on senolytics and senescent cells by Richard Miller in this most recent Peter Attia podcast interesting (and surprising, to be honest).

Check it out. I’ve queued up the video to the start of the senolytics discussion:

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#176

I think HDAC inhibition is an important part of this process (Fisetin is a HDACi), but not the only part.

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#177

John, any thoughts on why Fisetin failed in the ITP study recently?

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#178

I don’t really. I am currently taking between 10 and 20 HDAC inhibitors. It may be that Fisetin out of the combination is in fact useless. However, what am trying to do is to get overall results. If one or more of the molecules I am taking are not helpful I won’t necessarily find that out.

In the end I don’t mind doing some useless things (or even counter productive things) if the overall outcome is an improvement in health status (which is what seems to be happening).

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#179

Yes. This talk about scenescent cells and aging is very similar to the talk with Dr Miller and Dr Kennedy where they essentially agreed that the theory that scenescent cells is a driver of aging has not been proven.

For me, this means I will not try to directly kill scenescent cells but instead focus on not making scenescent cells (avoiding damage) and improving my immune system to clear “bad” scenescent cells that need to be cleared.

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#180

@John_Hemming Do you use a cyclic approach to your HDAC inhibition efforts or just push it down as much as possible?

#181

Personally, I think senescent cells are like a low grade cancer. They not only are malfunctioning cells, but they can travel through your body and convert nearby healthy cells into more senescent cells via SASP. They create inflammation through SASP and your body tries to clear them up on its own.

Senescent cells are not good even though some may be less bad. I will continue to use senomorphics like Rapamycin and taurine. Eventually I’ll use dasatanib and quercetin too.

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#182

I have some that I take all the time and separately a cycling approach. I have also tried different doses at different times on an experimental basis. At the moment I am cycling a high metabolic state with a low metabolic state and when on high metabolism I am also increasing HDAC inhibition.

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#183

@John_Hemming Thanks. That makes sense.

#184

I think there is a substantial difference when it comes to how fisetin is administered.

  • The ITP gave it through the food.
  • Kirkland and others have mostly focused on high doses given intermittently.

I think this difference is something to consider. Personally, First I take some black pepper and then I take fisetin 30 - 40 mg/ kg body weight, consumed with canola oil.

The first time I did these treatments, I got a profound effect. First pain relief, increased sex drive and muscle weakness. After a few days, I got a strong rebound when it comes to muscle strength.

Now, after a few years with taking this 3–4 times a year, the effect from this kind of treatment is reduced. But it still gives me an increased sexual stamina, some pain relief and increased wellbeing for a few days.

I’ll continue doing it. Now, I often mix the fisetin treatments with other substances that are claimed to be “Senolytic”. Quercetin, piperlongumine, theaflavines

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#185

The ITP does check whether the compound in question does get absorbed into the bloodstream so it’s not an issue of bioavailability.
Imo fisetin failed in all regards and is a dead end.

#186

This has been discussed before;

I use Azithromycin.

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#187

What dose? What is your protocol?

#188

What is your protocol, weekly, monthly, semi-annually?

1 Like