Fashion sense? I find that my wardrobe has fallen out of fashion….and I think what is popular now looks silly. I’ll bet that makes me look old, eh?
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I think this is one of the key psychometric biomarkers of aging 
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Alex
#117
What formulations are people planning with respect to Desatanib / quercetin here? It looks very promising for a spot test anyway.
Alex
#118
Consider such clothing to be senescent and purge it!
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Alex
#119
A mundane question please. Where do you buy Transcutol? I am not finding it for sale anywhere online anyway.
Also, I notice many different kinds of Transcutol listed. Transcutol, Transcutol P, Transcutol Gattefosse.
What brand / type are you buying?
More info in the above thread. I buy mine from Lotion Crafters.
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My plan (I’m working this summer on gathering up all the compounds) is dasatinib (no querciten as it likely stains the skin) plus:
Strong potential senolytics including:
- Sertraline
- Fluvoxamine
- Nortriptyline
- Verapamil
- Amiodarone
as per this post here: Senolytics Topically Administered to Skin for Antiaging Effects - #30 by RapAdmin
Mixed with transcutol as done in the DIY rapamycin thread: DIY Rapamycin skin cream
Then added to CeraVe body cream for final application.
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I seem to be the only one pointing out the serious dangers of Vitamin A. I used it topically for several years and got vitamin A poisoning. Most people who develop problems don’t make the connection. See my posts here: Low Carb Diet ⋆ EUREKA (PART 1) ⋆ Carb Wars Cookbooks
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That’s because you are an outlier.
This is the first I have ever heard of this.
Maybe you got too much vitamin A from your diet, carrots, etc, or food supplements.
Retin A (tretinoin) has been used for many decades for teenage acne, sun damage, etc.
It has an excellent safety profile.
Tretinoin, when applied topically, has minimal systemic absorption into the bloodstream.
The amount of tretinoin absorbed through the skin is typically too low to cause vitamin A toxicity or hypervitaminosis A.
Factors Affecting Absorption
Intact skin acts as a barrier, limiting the absorption of topically applied tretinoin.
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Alright, I have the ingredients for the recipe and will begin mixing it up soon, with tests on the back of my hands and sun-damaged neck.
If I am an outlier, there are a LOT of us. Use of retin-A skin treatments may explain why more women than men have autoimmune conditions like Lupus and Fibromayalgia.
Does the skin really act as a barrier to prevent the absorption of vitamin A? It all eventually breaks down to retinoic acid and goes to the liver to be detoxed. When the liver can’t handle any more, it is wrapped in Retinal Binding Protein, made by fat cells, to prevent it from coming into contact with and burning tissues. More fat may be necessary to handle the overload, which may contribute to obesity.
Look at the insert (iPLEDGE REMS) that comes with prescriptions for the acne medication, Accutane, to read about the serious side effects of the drug (Accutane is really just pure retinoic acid, the end metabolite of vitamin A). They are like those of Thalidomide, the drug for morning sickness that caused babies to be born with multiple abnormalities, including missing limbs. The Accutane brochure carries this warning: “There is an extremely high risk that severe birth defects will result if pregnancy occurs while taking isotretinoin in any amount, even for a short period of time.” You must sign 2 legal documents to acknowledge that you are aware of the danger before you can even buy it.
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Please cite any studies that show any studies that show what you say is true.
A systematic review says the side effects are minimal.
Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112391/
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I highly doubt that’s true. We already know that one reason women are more prone to autoimmune diseases than men is because they tend to have a stronger and more aggressive immune system.
As far as the accutane risks such as severe birth defects. That’s because accutane is taken orally. That’s very different from applying vitamin A derivatives to your skin.
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Just curious, why not just use topical tacromilus gel or better yet, Pimecrolimus Topical, which does not have as many sides instead of creating a topical sirolimus? These meds cannot be used on a regular basis, but maybe used intermiitently just as we use the oral rapamycin.
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Hyftor which is sirolimus topical gel 2% is another option, if one can find a way to get a script for it. I would only use this once weekly as with oral rapa.
PYM
#132
Tacrolimus and Pimecrolimus are calcineurin inhibitors. Sirolimus/Rapamycin is an mTOR inhibitor. Despite having similar sounding names, they are quite different and have different effects, ie you cannot substitute Tacrolimus/Pimecrolimus for Sirolimus/Rapamycin.
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Yes - but I don’t think it inhibits mTOR nearly much as the rapamycin and the rapalogs like everolimus and temsirolimus. I’m not sure of the exact comparison, but if you want to inhibit mTOR you probably want the main mTOR inhibitors:
PYM
#135
Thanks for pointing this out. Will look into it.
The only reason to use it would be because it is available as a topical. Hyftor is the only sirolimus topical that I am aware of, and it seems like the logical choice. Hyftor appears on Indiamart by various sellers, but not on Oddway’s portal.
