SCFAs are produced in higher quantities by Acarbose usage.
6 Likes
The larger message is a healthy gut microbiome is good for you. A healthy gut microbiome makes more SCFA. A diet with lots of fiber, resistant starch and phytonutrients encourages more good bugs to out compete bad bugs in the gut. Acarbose may help with gut microbiome composition (presumably by sending more food into the bowel for the bugs to eat). Eating celery is also good for you.
7 Likes
Bicep
#4
Jerusalem artichoke. My attempt at increasing SCFA. As I read about it, it seemed like a cheat code because it is mostly fructoligosaccharides (sp). Also a complete protein. I’ve eaten a few and they are delicious and a little like a water chestnut. Best in salad.
Grows like crazy. I put them by the road because gravel roads send a cloud of dust every time somebody drives by. These guys were supposed to slow that down.
9 Likes
How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
Open Access Paper:
Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better understand the function of these modifications, we used chromatin immunoprecipitation followed by sequencing to map the genome-wide location of four short-chain acyl histone marks, H3K18pr, H3K18bu, H4K12pr and H4K12bu, in treated and untreated colorectal cancer (CRC) and normal cells as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions and gene expression to access the function of the target regions. Our data demonstrate that propionate and butyrate bind and act as promoters of genes involved in growth, differentiation and ion transport. We propose a mechanism involving direct modification of specific genomic regions by SCFAs resulting in increased chromatin accessibility and, in the case of butyrate, opposing effects on the proliferation of normal versus CRC cells.
https://www.nature.com/articles/s42255-024-01191-9
Paywalled paper:
Divergent roles for propionate and butyrate in colorectal cancer epigenetics
https://www.nature.com/articles/s42255-024-01186-6
2 Likes
Acarbose increases SCFA as well. This is probably one of the mechanisms as to why mice (little cancer factories) live longer when taking Acarbose + Rapamycin.
Bicep
#7
Acarbose sends glucose to the colon, which feeds all bacteria and when present there the bad guys do well. This is according to papers I have read about XOS. Xos feeds only the lacto, bifido, and a couple other good guys, but does not feed the bad guys. I wonder if that’s why acarbose causes so much discomfort, while the xos really doesn’t. I’ve had a tub full now and there is really no side effect so far.
Amazing paper…amazing product.
1 Like
Bicep
#8
Notice on this site:
Price barely moves when you go from 100 to 500. You want to buy the big bags…most of the cost is putting it into the bag and sending it to you.
1 Like
And inulin is also a good product class for SCFA:
and
jnorm
#10
Does nobody supplement the SCFA butyrate? I thank my lucky stars for tributyrin, as I partially credit it with healing me from a terrible 3 year case of gastritis. I’d really love to see it tested in the ITP.
Bacterially produced butyrate is also the primary energy source of coloncytes, which I find a remarkable fact. 
And inulin is also a good product class for SCFA:
Also, it extends mean+max lifespan in female mice (dosage unknown) relative to long-lived controls, according to METHODS AND COMPOSITIONS FOR EXTENDING LIFESPAN
3 Likes
Yes, tributyrin is interesting, but I can’t find it among any supplement brands I trust, such as NOW, Jarrow etc., instead it’s sold by either brands completely unknown to me, or scammers like Dr. Gundry. Given the extremely high levels of fraud in the supplement industry, I’m loath to experiment with some mystery brand; you never know what you’re getting or worse. YMMV.
3 Likes
Yes - I saw exactly the same thing… lots of 3rd rate (or unknown to me) suppliers… so I think I’ll just avoid it rather than waste my money.
1 Like
jnorm
#13
Good point. I’ve been taking it for a few years now, so I might have some tested to make sure my supplier legitimate. NuMega Resonance in San Diego is <$100 for quantitative NMR, so it’s not bad for something I plan on taking long-term.
1 Like
Butyrate is an HDAC inhibitor and acetate increases cellular levels of acetyl-CoA via ACSS2. However, ACSS2 operates a cellular level homeostasis so it can only go so far.
2 Likes
What about this compound… I wonder if its worthwhile, potentially? Anyone have thoughts?
I don’t know about propionate (3). Acetate (2) and butyrate (4) are known to be helpful, but in different ways.
Given that there are limits as to what one can eat in total I am not personally of the view that I would add this to inputs as I don’t know of any good reason for doing so.
1 Like
PBJ
#17
I agree with you on reputable brands, however I would feel pretty comfortable buying a trademarked product such as CoreBiome.
Triacetin is an interesting molecule that converts to acetate. It was at one stage thought of as something to provide nutrition to astronauts.
I have eaten a bit of it, but cannot make any comment about any effects. It is probably a less harmful way of getting acetate than either vinegar or alcohol.
JuanDaw
#19
How about Nutricology?
https://nutricology.com/privacy-policy/
6. Ownership
NutriCology® is a wholly-owned subsidiary of KI NutriCare, Inc., a wholly-owned subsidiary of Kikkoman Corporation.
PBJ
#20
That product is just a prebiotic. I would just take Inulin instead.
I use Designs for Health Tri-Butyrin Supreme sometimes if I can find it for around $35 for 60 capsules. It uses CoreBiome which is trademarked. There are some other brands that use CoreBiome also.
ButyraGen
-
Active Ingredients: Prebiotic blend designed to stimulate butyrate production by gut bacteria.
- Includes fibers like resistant starch, beta-glucans, and fructooligosaccharides (FOS).
1 Like
