Actually about Bempedoic Acid, is it really necessary to lower cholestrol? My cholestrol is very low for some strange reason. I thought we need higher cholestrol to live longer? (something I read recently). Plus I love my BBQ and fried foods. If I stop my chocolates for 3 months my LDL will drop.
My historical results above.
BTW, what is CR?
According to your records, your latest LDL would be 96 in American terms. Anything above 50 is building plaque. I’d be taking Bempedoic Acid and it should take you down to 50. I was at 120 and am now at 65. It’s still building plaque but at a slower rate. I’m going to try Atorvastatin to see if I can get it lower, but I’m afraid I won’t be able to tolerate it.
CR is Caloric Restriction.
As an aside, My LDL was at 67 before I started taking Rapamycin, so Bempedoic Acid + Ezetemibe is countering the hyperlipidemia from Rapamycin.
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Started rapamycin on June 3 (5 weeks ago) as 1mg/wk x 2-3 wks, then 2mg/wk x 2 wks, and today 3mg.
PVCs: I noticed increased PVCs (extra heart beats) initially but those have disappeared.
Defecation Reflex: Also noticed (well, struck with) intense defecation urgency the day after a dose. That has improved-- I don’t have to use the park Porta-Potty when exercising, but can wait until I am home.
Exercise Regimen: I have been on the same exercise regimen for years: I arrive at a local dam at 6:30am and do 9000 stair steps over 1.5 hrs. The steps have an 8" rise x 111 steps up. I think I feel better, even on the day-of dosing and the following day than I did before rapa. My stairs are followed by push-ups. I go to exhaustion and could do 45-50 before rapa and that has decreased by 10%, again to exhaustion but we have had a heat wave which means more cardiac output goes to the skin for cooling than when it was cooler. I sweat horribly and drink up to 1/2 gallon of water while doing the steps in this weather.
Infections: Other than a brief episode of subclinical shingles (my diagnosis) initially, I have not had any infections, not even a folliculitis (pencil eraser-sized skin infection at the site of a hair root) common in those who exercise and sweat lots.
Blood sugars: I use a continuous glucose monitor (Dexcom G7), which I calibrate with a glucose meter. I do not eat bread, pasta, anything with added sugars, cereals, ice cream, etc. My fasting and postprandial glucose rose by 10% each based on lots of prior data. Today I am receiving from India remogliflozin (an SGLT2 inhibitor) that is inexpensive and efficacious and not sold in the US.
Plan: Continue to slowly increase dose, probably to 6mg.
Favorite quote: Back when I practiced emergency medicine, we used to joke when a new med came to market, “Be sure to use it in the first three months while it still works!”
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adriank
#1149
Today after taking 20mg of rapamycin… 2.5 hours after GFJ and breakfast… hoping to see a better result for my 24hr blood test. Today in the pool I feel tired… maybe I have been slack but my arms were unusually heavier and fatigue. Anyway, it is winter and I wanted to stay in the heated pool. So how many days do we stop exercising after taking rapamycin? I am thinking of switching to a dinner time dosing but it will screw up my lab data which I cannot do at night for 24 or 48 hours. Unless I start collecting 36 hours or 40 hours data. If I have my rapamycin say at 9pm which should be 3 hours after dinner… my 36 hour test will be at 9am the day after tomorrow. Any suggestions based on your experiences?
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Wow - thats a really high dose. So you’re saying 20mg of actual rapamycin/sirolimus, plus GFJ, so an effective dose of over 60mg+ of rapamycin.
Please let us know the test results.
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ng0rge
#1152
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But he’s encapsulated the Siroboon now, so it’s a really high dose.
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ng0rge
#1154
Hmmm, so without encapsulating, Siroboon is one tenth the potency of Rapacan? But encapsulating makes it the same?
Wouldn’t 16 mg of Rapacan with GFJ likely give you an even higher blood level?
adriank
#1155
My next batch will be Biocon and I’ll compare the data after.
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adriank
#1156
I always have plenty of activated charcoal pills handy… Even if it is just for tummy ache.
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adriank
#1157
This few days I finally realized I am suffering from tonsillitis. Is that a side effect of sirolimus? It is almost dull unlike any tonsillitis I’ve ever had but when I just checked in the mirror I definitely have very inflamed tonsils. This is my first. Anything passing through my throat hurts but otherwise it is weird it is not giving me a bad sore throat…
59vw
#1158
apthous ulcers (caused by rapa) can occur on the tonsils. It feels like tonsillitis. Can you see white flat ulcers on your tonsils?
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adriank
#1159
Actually I went to the doctor. It is unrelated. I have tonsillitis but it is not as painful as it normally is. I got a script of penicillin but I might wait a little longer. So weird.
Update… Anyway this morning it decided not to bother me. Just unusual to have such mild tonsillitis.
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So, today I took 7 mg of Rapamycin + GFJ and about 39 red itchy bumps on my torso that feel like mosquito bites. However the rest of my body is fine.
Has anyone else had a similar reaction?
There’s more on the torso, but you get the picture. It’s only on the torso, so it probably isn’t mosquitoes?
I did take my regular supplement stack as well after being on a two week vacation break.
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Hives? I haven’t had such a reaction from rapa or grapefruit.
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It seems I may have developed an allergy to something.
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From Google:
Hives can appear within 30 minutes to 1 hour after eating a food that triggers an allergic reaction. Common food allergens that can cause hives include peanuts, shellfish, eggs, nuts, milk, soy, and wheat. If you have a latex allergy, hives can also be triggered by bananas, chestnuts, kiwis, or mangos, but they usually appear 12–24 hours after eating.
Hives can appear 12–24 hours after exposure to additives in foods, vitamins, supplements, spices, cosmetics, skin care products, toothpaste, and other products.
Hives can appear immediately, days, weeks, or years after starting to take a medication, such as antibiotics, aspirin, or ibuprofen.
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I think this probably is rapamycin inhibiting an immune response. There are two options as to why I don’t have the same response.
One is that I am not actually taking Rapamycin, but a well fabricated fraudulent drug from two different vendors. Occams Razor says that this is not true.
The other that is with me taking a lot of citrate my cells have already killed off lots of infections which otherwise would require the immune system to create new immune cells. Hence switching off that system (temporarily) has no obvious effects.
To explain this a bit more. Cells have an ability to fight things they wish to fight without bringing in the immune system. This is done by using ROS from the cytosol. That requires acetyl-CoA.
Hence if you have a young cell with lots of acetyl-CoA it can fight things like warts that older cells cannot
Hence, as people get older their cells tolerate things that younger cells would resist. Hence there gets to be a continual battle between the immune system and infections where the infections are never actually got rid of, but just reduced.
However, it is possible to increase the ability to fight this at a cellular level. Hence the infection is got rid of and when the immune system is reduced in an attempt to increase autophagy there are no infections to cause difficulties.
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No side effects I could attribute to Rap in 2 years.
6mg every 2 weeks - grapefruit the night before and taken with spoonful of EVOO the next morning.
I took some Claritin and the itchiness, redness and size decreased. So, the hives definitely appear to be an allergy to something.
