#901

My BP was improved with nitric oxide and potassium. Worth a try if you haven’t. Good luck.

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#903

On my new dose of 6 mg + GFJ + EVOO + Metformin (21 mg equivalent) bi-weekly. The first couple of days after dosing, my feet and ankles were mildly swollen upon waking from sleep.

Also had a weird headache in the lower left side of my head while sleeping which I am not sure if it is related. It lasted only one day, but it seemed to go away if I turned my head to the left and came back if I turned it to the right. Quite strange as I have never had that before. Anyone else have this?

I am not getting the fatigue any more (thanks taurine!) but it appears I am not getting as much euphoria as before either. I do have a general sense of well being though.

Also, definitely slow wound healing. Of course, the night after I took my dose, I scratched up my wrist and palm pretty badly. The four open wounds are all red, irritated, inflammed and infected even though I applied neosporin and bandages. (although the bandages fall off quickly. Hard to stick on an active joint!) They are healing, but at a noticeably slower rate than if I didn’t have as much Rapa in my system.

2 Likes
#904

Rapamycin, if overdosed, can be hard on kidneys. You may be overdosing with GFJ. Your swollen ankles point to possible kidney problems. And if you have kidney problems, there’s a greater risk of lactic acidosis with Metformin. Have you checked your kidneys recently?

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#905

I have checked my kidneys via blood tests. They are fine. But, it’s good to know and watch out for. If I continue to have this problem, I will cut down on my Rapamycin dosage.

The point of this experiment is to see how a high dose of Rapamycin affects my health over a 2-month period. I’ll be getting a complete physical and blood work at the end of December. I was originally going to try 40 mg over 3 weeks, but I didn’t want to risk rebound, so decided to try 21 mg. It is possible that it is higher beyond the calculation, but without a Rapamycin blood test here, I’m using the computed values.

1 Like
#906

17 posts were merged into an existing topic: Improve Bioavailability of Rapamycin (2)

#909

Why do you think you are having a problem with mTORC2? Are you experiencing increased infections, etc?

2 Likes
#910

Immunosupression. Lowered neutrophils and in particular lowered lymphocytes. Mild pneumonia, solved with an antibiotic.

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#911

Mostly theoretical. I have had neck acne a few times (a single pimple each time), a couple mouth ulcers, and a single instance of gum inflammation that lasted a few days. I worry more about what is happening that I can’t feel.

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#913

life extension has a blood test for rapamycin levels. unfortunately, they only do it in the Fort Lauderdale lab. the last time I did it there it was $95

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#914

There are a few companies in the US that provide inexpensive blood sirolimus level testing: How to get a Rapamycin (sirolimus) Blood Level Test

In Europe and elsewhere it can be more difficult. If you find one outside of the US, please post information about the lab and cost.

People have said that in the UK this is an option: Doctap.co.uk charges £134 (plus the £50-£70 consultation fee - obviously not extra if having other tests done) in the UK.

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#915

There is still some swelling in the bottom of my left foot which is odd. I think I may need to dial down my Rapamycin dosage to 5 mg + GFJ when I take my next dose in 2 weeks.

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#919

The ITP had one arm where they cycled the mice on and off. Besides that, I think most other studies use rapamycin in food and a continuing feeding.

2 Likes
#920

Usually I take rapamycin without any supplements or food and never have mouth sores. Last week though, I was taking it with reserveratrol mixed in EVOO (wanted to see if resevatrol has any effect on glucose spike). The result: 2 mouth sores after taking 0.5 mg/day for only 3 days.

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#921

Rapamycin = Senomorphic
Rapamycin + Resveratrol = Senolytic

When you add Resveratrol, it kills off senescent cells instead of rejuvenating them.

2 Likes
#922

I thought Resveratrol was debunked. Thought there is a lot of reading on it NOT being beneficial?

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#923

I recently read on this forum that if combined with Rapa, reseveratrol prevents glucose spike.

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#924

Ah, I see wasn’t aware of that. Makes sense if true. Any paper or source that you can remember, or just anecdotal?

#925

Unfortunately don’t remember besides it was recently within 2 weeks. So I decided to try but it immediately resulted in 2 mouth sores. For me it’s a negative feature, so I stopped reseveratrol.

1 Like
#934

There’s a whole thread on Rapamycin plus GFJ. GFJ has been tested with Rapamycin. It provides around a 3-3.5X increase in bioavailability and the effects of GFJ lasts only 4 hours and not 3 days.

5 Likes
#935

I listened to your podcast re: nitric oxide but I don’t even want to get the test strips before I know what to do about it. Was disappointed that that was the only product they offered, then just general guidelines. So for example, assume that I am deficient as you were. Assume that I’ve already ditched mouth rinse. What toothpaste is friendly to the ammonia oxidizing bacteria in our mouths? I already see the foods to incorporate but you can’t start drying yourself when you’re still in the shower with the water running. I’m surprised that woman’s company hadn’t at least launched a toothpaste that ticks all the boxes. Have you found one? What else have you done re: intervention?