#1210

I have been able to eliminate my itchy hives by alternating between 4 mg + GFJ + EVOO and 3 mg + GFJ + EVOO every other week. I guess this is as high as I can go without any side effects.

3 Likes
#1211

Me too. That is the exact dose that I have come to use. Otherwise I don’t get any symptoms, but my numbers go stinky bad and (even though it’s unproven that this is a bad thing) I get nervous about it and decide to reduce my dose rather than use MORE PHARMA.

3 Likes
#1212

I decided to try 6 mg + GFJ + EVOO today after taking a break last week. I am having a gut-wrenching stomachache. I think my body is telling me to stay at 5 mg + GFJ and below. I don’t think I want to go through this pain again. :stuck_out_tongue:

7 Likes
#1213

I am now wondering if it wouldn’t be more effective to aim for much smaller but more constant concentrations of rapamycin over time for purposes of controlling increasing mTOR activity associated with ageing while limiting off-target effects. I had to drop down to 2 mg/month to avoid dose limiting effects, for me aphthous ulcers and carbuncles, and had been tolerating that dose without problems. I attribute those side effects to mild immune disruption. I am now on 1 mg every two weeks and I am avoiding what are for me dose limiting effects. I wish I could experiment with 100 - 200 mcg/day.

Daily pterostilbene may be an alternative but the issue is lack of human studies on dose for adequate mTOR suppression.

1 Like
#1214

Have you tried 0.5mg to experiment with?

1 Like
#1215

I would consider it but being somewhat conservative, I prefer to use Pfizer’s rapamycin due to its well studied pharmacokinetics. It’s only available in 1 mg doses from my supplier. I just saw they do make a 0.5 mg dose as well as an oral solution. The oral solution would work.

2 Likes
#1216

Pfizer produced 0.5 Rapamune pills (as well as 1 mg and 2 mg), however it discontinued production and sale in the U.S. on Dec 31, 2024 (patent expires and generic sirolimus is available). Are you sure you receive brand- name Rapamune by Pfizer from your supplier?

1 Like
#1217

Yes, it is sourced from Pfizer / Turkey. Thanks for your concern as there is a lot of contraband out there!

#1218

Below is a link to the LAM foundation letter regarding discontinued Rapamune in the U.S.

1 Like