Anyone here have experience/information on Lemborexant (Dayvigo)? Have read that it is a sleep promoting med that now has been shown to have neuro protective capability.
Tim
#348
Hereās list of 78 sleep meds, with a rating for each by users. Back in the good old days, I ordered five from India to experiment with. I may end up alternating between a couple monthly or bi-monthly.
https://www.drugs.com/condition/insomnia.html
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I have used both trazodone and quetiapine (Seroquel) in the past, and I keep some on hand just in caseātrazodone for decreasing sleep onset and quetiapine for increasing sleep duration.
These are sub-therapeutic doses and have few, if any, side effects at the dosages required for sleep improvement.
IMO: They are safer, especially for older people, than anticholinergic otc drugs sold as sleep aids.
For those interested, you can read a description and reviews from users on Drugs.com
https://www.drugs.com/comments/quetiapine/for-insomnia.html#google_vignette
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Tim
#350
I know you take quetiapine, as do I. But I get side effects, even at 25 mg. Accounting for individual differences, I find it to be harsh. Some 32% of users report a weight gain on Seroquel. I havenāt gained any weight because I have a high metabolism, but Iām always hungryāravenously so.
scta123
#351
Be careful with quetiapine for sleep, itās not really meant for that and has been linked to heart issues and even increased risk of sudden death. There are much safer options.
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Cetirizine, an antihistamine that causes drowsiness.
Iāve had a cold that is also combined with allergies, so I decided to try out some antihistamines before bed until I recover from the cold. I went from having trouble getting to sleep and 5 hours sleep to getting to bed early, sleeping easier and getting 8 hours sleep.
Iām going to experiment with low dose ketotifen (0.25mg a night) for a while in the future as Iāve heard some good things here.
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How to get the best nightās sleep: what the science says
Chuck the gadgets, the fads and the alarm. Circadian research reveals how important your bodyās internal clock is to blissful slumber.
https://www.nature.com/articles/d41586-025-03148-8
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Jonas
#354
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Beth
#355
Iāve waxed poetically about my new sleep supplement in the melatonin thread, but after checking out my oura chart, I thought I would mention it over here, too.
Late August (I wish I knew the day), I started taking Solaray ER 10mg melatonin and 1000 mg glycine every night before bed (that is one supplment and not two different ones), and my sleep has hit a new level of consistency and length.
It had already improved tremendously since starting rapa and LDN and a host of other things, but this new sleep is next level.
Note: I had also experimented with other melatonin before bed, or taking it in the middle of the night when I woke to help me fall back to sleep (which worked), but ever since starting this one thing, and being consistent, I might have had only 1 or 2 sub 7 hour nights, and maybe up in the middle of the night once or maybe twice at the most.
I imagine it wonāt work this well for everyone (or it would be in the news!), and I am confident my streak will end by the mere fact Iām posting this, so I hope you appreciate the sacrifice 
There is always a chance it could be a coincidence but I now sleep between 7:30-9 hours each and every nightā¦ this consistency has never happenedā¦ itās CRAZY!
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Bicep
#356
Yes, I think this is possibly the cheapest hack out there. Easy to do and I think it makes a big difference. Possibly pure placebo but I donāt think so.
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LaraPo
#357
My sheets probably have grounding capabilities because as soon as I get in bed I fall asleep almost immediately 
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Tim
#358
I am wired during the day and fight insomnia during the night if I donāt take a pill. Before the tariffs, I ordered some gabapentin from India and found 600 mg to be a wonderful soporific. But since that avenue is now blocked, I made an appointment with my doc, and he prescribed 300 mg/night, which doesnāt do the job. Neither does 600mg. The Indian brandās 600 mg is much stronger than the US-filled Rx. This is kind of a puzzle to me and puts me in a pickle.
Nick1
#359
Yes, having an early meal (at least 3-4 hrs prior to bed time), wind down routine( no screen time for an hour, reading some books), blue lights blockers and Magnesium (l-threonate and citrate) +Taurine does the trick besides cooler room temperature. I also do a 2-minute body scanning (Yoga nidra) as final activity when eyes are shut and lights are out!
I tried glycine and my REM went up at the expense of deep sleep with disturbingly vivid dreams!
Here is the link to cheap blue light blockers I dawn in the eveningā¦they have $80 ones too but i go with larger frames so they fit my prescription glases.
NightFall True Red Lens Blue Blocking Glasses - Dark Black Frame
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There are five types of sleep ā hereās what that means for your health
Scientists have identified five sleep profiles, each of which is linked to distinct mental health symptoms and brain activity patterns
To take a more holistic approach, Valeria Kebets at Concordia University in Montreal, Canada, and her colleagues analysed the association between seven factors related to sleep ā such as sleep satisfaction and the use of sleeping aids ā and 118 other measures, including cognition, substance use and mental health. They collected data including cognitive tests, sleep surveys and brain scans from 770 adults aged between 22 and 36 who lived in the US and had no known health conditions.
From this, the researchers identified five distinct sleep profiles. The first was characterised by a general pattern of poor sleep ā greater sleep disturbances, decreased sleep satisfaction and taking a longer time to fall asleep ā and worse mental health, such as depression and anxiety symptoms, as well as anger, fear and stress.
Read the full story: There are five types of sleep ā hereās what that means for your health (New Scientist)
One thing worth mentioning is that if you are a man past about 50 years of age, Iād be careful about taking GABA for sleep. Iāve seen several articles on the web saying GABA signalling worsens and maybe even initiates prostate cancer. This doesnāt prove taking the supplement will make things worse, but Iād tread carefully.
If you could give some links to these articles that would be helpful.
Hereās a Gemini 2.5 Pro link with some article references:
The links in that didnāt work so I asked Gemini the same question asking for working links. For some reason I could not create a share of the response so I copy it here:
The available research suggests that GABA signaling is associated with a reduced risk and progression of prostate cancer. Studies indicate that GABA, the primary inhibitory neurotransmitter in the central nervous system, can hinder the growth of prostate cancer cells and encourage apoptosis, which is programmed cell death.
The mechanism for this is believed to involve the activation of GABA receptors present on prostate cancer cells. This activation interferes with the signaling pathways that would otherwise promote the cancerās growth and survival. Therefore, rather than increasing the risk, the current scientific understanding points towards a protective or even therapeutic role for GABA signaling in the context of prostate cancer.
So I asked chatGPT and got a response which confirmed in some ways both answers and I have tried to get a share from this, but it has seized up.
If it provides a share later I will edit this post.
voila!
Including the bottom line from that:
Bottom line: Evidence from cells, models, and patient tissue leans pro-progression (not protective) for GABA signalling in prostate cancer. That does not prove that dietary GABA or GABA-acting medicines increase a personās chance of getting prostate cancerārobust human incidence data are lacking. If medication changes are on your mind, discuss with your clinician.
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