You have my sympathy.
IMO: I would certainly not pursue alternative medicine or other unproven therapies at the beginning of discovering cancer. But, once it reaches stage four and the doctor’s therapy is not stopping or curing the cancer, all bets are off.
What have you got to lose by trying any alternative solutions?
My wife died from the complications of breast cancer. I am so sorry I did not intervene with the doctors’ therapies when it continued to progress.
10 Likes
ng0rge
#62
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer
New combination therapy approach for pancreatic cancer.
https://www.science.org/doi/10.1126/scitranslmed.adj9366
Unlike other tumor types, existing immunotherapies have not proven very successful for pancreatic ductal adenocarcinoma (PDAC), necessitating the development of additional approaches. Here, Chibaya et al. developed a combination therapy approach that included nanoparticle delivery of STING and TLR4 agonists, which stimulate the immune response, in combination with the MEK inhibitor trametinib and CDK4/6 inhibitor palbociclib, which promote senescence of tumor cells. The combination therapy induced robust antitumor immune responses that controlled tumor burden in implanted and autochthonous PDAC mouse models. These data support further development of this potent combination therapy for PDAC.
Pancreatic ductal adenocarcinoma (PDAC) has quickly risen to become the third leading cause of cancer-related death in the United States. This is in part because of its fibrotic tumor microenvironment (TME) that contributes to poor vascularization and immune infiltration and subsequent chemo- and immunotherapy failure. Here, we investigated an immunotherapy approach combining delivery of stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) innate immune agonists by lipid-based nanoparticle (NP) coencapsulation with senescence-inducing RAS-targeted therapies, which can remodel the immune suppressive PDAC TME through the senescence-associated secretory phenotype.This two-pronged approach produced potent T cell–driven and type I interferon–mediated tumor regression and long-term survival in preclinical PDAC models dependent on both tumor and host STING activation.
Collectively, our results suggest that engineering approaches to target multiple cell types and immune suppressive barriers through induction of type I IFN signaling in the PDAC TME could pave the way for coordinated innate and adaptive immune responses to achieve immunotherapy successes that have thus far been elusive for patients with PDAC.
3 Likes
Ludovic
#63
The antiparasitic drugs fenbendazole and mebendazole can also be considered as a last ditch effort in case of cancer in general;
Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells - PMC.
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Two weeks ago, we celebrated my father-in-law’s 80th birthday at a restaurant. He could walk and manage on his own although he had bouts of pain. It has been 3 years and 3 months since the initial diagnosis.
My father-in-law is now in the hospital. He is too weak to walk or even sit up. He can no longer talk or eat. He survives on an IV drip. He is in constant horrible pain such that he is continually moaning and crying. Only the morphine provides release.
When he is discharged from the hospital, he will be moved to hospice where he will stay until death. This is not how you want to die.
The only shining light is that my wife and her sisters are constantly at his side, holding his hand and talking with him. He is lucky in this sense as no one else in his ward has visitors that are constantly at their side. Too many elderly die alone.
The best treatment for cancer is prevention. That’s a big reason why many of us are taking Rapamycin. Cancer is a horrible way to die.
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He took 1 mg of Rapamycin daily (off and on) since June. It appears that dose had no effect. A higher dose may have worked better, but he didn’t want to try that.
1 Like
Increasingly, researchers are adopting the view that it makes sense to regard and treat cancer as a metabolic disease primarily. Yes, it may be instigated by a mutation of other insult to the cell, but the best way to stop it is to make its environment inhospitable to growth. Witness the research focusing on the TME tumor microenvironment. This is approach is also central to Jason Fong’s view in The Cancer Code, and aligns with the emerging view that most disease has an underlying metabolic component. For a practical and comprehensive approach, Jane Mclelland “How to Starve Cancer without Starving Yourself.” She provides specific strategies including some of the things discussed above: doxicycline and other antibiotics, metformin, melatonin, helminths (dewormers) such as fenbendazole. Why does a dewormer work so well against cancer?
If you read Fong you learn that a cancer cell is a cell that has gone into survival mode and has jettisoned its higher level programming and its role as a cooperative member of a complex eukaryotic multi-cell organism. A cancer cell is in heavy growth, every man for himself mode. Having been “injured,” has dropped back to a level of function that makes it behave like a simple single cell organism, abandoning its specialized higher level functioning and it role in the larger society/organism. So a drug like fenbendazole that attacks a simple organism is effective in attacking a cancer cell.
Mclelland together with Fong are by far the most insightful and also practical books I have read on cancer genesis, behavior, and treatment. Cannot recommend highly enough.
9 Likes
I tend to agree with the view that it is a failure of OxPhos leading in the main to aberrant splicing.
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For general interest purposes:
A specific variant of pancreatic cancer:
4 Likes
For future consideration - certain foods can prevent or diminish the anti-cancer action of statins:
https://pubmed.ncbi.nlm.nih.gov/35111242/
4 Likes
Karel1
#70
The publication @Chronos Tempi mentions contains valuable info on which food stuffs diminish the effect of statins. Especially geranylgeraniol present in may common things we may eat or drink like green tea, lettuce and many more may be damaging if statins are needed.
The full article is also in europepmc.org if you type 35111242 .
It makes me reconsider the use of green tea as an anti-oxidant
4 Likes
ng0rge
#71
This is important because Geranylgeraniol (GG) Supplements have been recommended here when taking statins to relieve muscle discomfort and fatigue, if CoQ10 doesn’t work. GG is promoted as a more effective CoQ10. Pitavastatin is supposed to have little (or no) muscle effects. From the paper:
We have previously shown that the potential activity of statins as a cancer treatment depends on the reduced production of geranylgeraniol. However, several human foods have been reported to contain geranylgeraniol, potentially bypassing the effect of the statins on the cancer cells.We have previously shown that geranylgeraniol, but not farnesol, reverses the activity of pitavastatin or simvastatin (6,8). Here we extended this and tested other products of the mevalonate pathway whose biosynthesis would also be anticipated to be blocked by statins. However, addition of coenzyme Q, dolichol or cholesterol had no effect on the activity of pitavastatin whereas geranylgeraniol did. Thus, we acknowledge that it remains a formal possibility that the ingestion of foods containing geranylgeraniol has minimal effect on the activity of statins as anti-cancer agents because insufficient geranylgeraniol reaches the systemic circulation from dietary sources.
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José
#72
Review Thomas Seyfried published work, He “has over 150 peer-reviewed publications and is the author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012).”
In my view he is correct.
A quote he uses in his lectures / presentation…
“It is difficult to get anybody to understand something, when their salary depends on them not understanding it.”
~ Upton Sinclair
Video of the September 21, 2024, presentatin at a BSI Medical Society event in Boston.
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The link between prostate cancer and aberrant splicing is well documented
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José
#74
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José
#75
Link this as it is about DON Dosing…
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My father in law has just passed.
The doctor was accurate in his prediction of 4-6 months until death. It was nearly 5 months.
He died in the hospital.
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I extend my condolences, may he rest in peace.
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RapMet
#78
My condolences to you and your family, may he rest in peace
2 Likes
LaraPo
#79
My condolences to your family.
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