#21

Sinclair is the worst. His MO of taking a supplement that is readily available and lobbying the FDA to make it a patented prescription drug for personal profit is truly slimy. His $720,000,000 fraud with Glaxo ends up costing us all money.
Matt Kaeberlein has given me no reason not to trust him so far.
Brad Stanfield seems to do a pretty good job reviewing the efficacy of supplements.
Rhonda Patrick makes too many far fetched, unsupported claims.
Peter Attia is hit and miss. His biases do not allow him to be objective enough for me, and he is making a fortune promoting AG1.
I am not aware of everyone, but it mostly gets worse from here.

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#22

What do you mean with this?

#23

Sinclairs company based on Resveratrol was sold to Glaxo for $720m and Glaxo subsequently wrote it all off as completely worthless. I forget which year they did this but it is in their Annual Report & Accounts from several years ago.
(Sinclair himself trousered a double digit $ million amount as by then he was only a minority shareholder).

4 Likes
#24

I can’t wait for your interview of VLMD. Her favorite cell is the macrophage. I know it’s too late but did you by chance get to ask her about beta cyclodextrin?

#25

Yes… here is the info. I think calling it “fraud” is too strong a term (at least given what I’ve read). Most small molecule R&D efforts end in failure, and Glaxo is a sophisticated company that did its due diligence. Did Sinclair overstate the potential, did the earlier studies his lab do have problems… you can decide for yourself.

https://www.nature.com/articles/nbt0310-185

https://www.science.org/content/blog-post/sirtris-compounds-worthless-really

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#26

The science on Resveratrol was junk. Are we to assume Sinclair did not know this? Anyhow, he is not a friend of the longevity community when he lobbies to remove supplements from the market.

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#27

I’ll never forget kaeberlein saying that he (and others) tried and failed multiple times to replicate Sinclair’s research.

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#28

How many compounds was in Sirtris Pharmaceuticals?

Which supplement was removed from market?

#29

I am not here to debate or do research for others that is available with a quick Google search. You are entitled to your own opinion in regards to Sinclair.
Sinclair created market demand for Resveratrol and MNM, then lobbied FDA to ban as supplements for monetary gain.

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#30

Well technically MNM was not removed from the market. He just wanted it to be sourced by companies that he had a financial interest in.
IMO: David Sinclair is more interested in fame and profit than science.

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#31

Which is very sad. Why can’t we ever get someone who cares about money and their own life?

#32

I think most scientists in the aging field are pretty good in this regard, Sinclair is the outlier. If you look at Kaeberlein, Brian Kennedy and the NUS scientists, the Buck Institute scientists, etc. most of them are very focused on moving the science forward with science that can be duplicated by other labs, and in helping the broader populace.

Generally this group of researchers is quite good. Some are getting more involved in commercial efforts, but the good ones don’t over-hype the results of their studies and acknowledge the limitations of their research.

5 Likes
#33

U.S. Food and Drug Administration (FDA) banned NMN in 2022 from being sold as a dietary supplement.

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#34

Yes - see this story

FDA Bans NMN as a Dietary Supplement: Why and What Happened?

Healthnews has compiled the timeline of events leading up to and after the FDA banned NMN. We detailed the twists, turns, and unexpected roadblocks for consumers and companies hoping to market the anti-aging compound.

However, the U.S. Food and Drug Administration (FDA) banned NMN in 2022 from being sold as a dietary supplement after initially allowing one company to market it as a dietary supplement, sending shockwaves through the supplement industry and organizations that support natural health products.

https://healthnews.com/longevity/longevity-supplements/fda-b-nmn-can-no-longer-be-sold-as-a-dietary-supplement-in-the-us/

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#35

There are many loopholes in this ruling.
There are still many ways to get NMN if you actually want some.
It is still being sold in the U.S. and can be imported from many countries like Japan.

“As of January 2024, the FDA has not enforced the ban on Nicotinamide Mononucleotide (NMN) supplements in the U.S”

“As of January 2024, the FDA has ruled that nicotinamide mononucleotide (NMN) cannot be legally marketed as a dietary supplement”

Some are even ignoring the "supplement’ ruling.
"Lawsuits Against FDA’s NMN Ban Could Be Coming Soon

“Healthnews
https://healthnews.com › News
Has the FDA enforced the ban on NMN supplements? from healthnews.com
Dec 4, 2023 — The FDA had previously accepted NMN as a New Dietary Ingredient (NDI), which allowed supplement manufacturers to market it.
It is currently still being sold in the U.S.”

https://www.muscleandstrength.com/store/ff-nmn.html?___store=default

P.S. I am only beating this to death because I have already been to the gym and done my chores, so for the moment I have nothing better to do. :grin:

3 Likes
#36

Well, I normally shop Amazon out of convenience, not that I like to support them, and they do not sell it anymore.
It’s OK, I have already read many of your posts and appreciate the knowledge and experience you share here.

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#37

Funny - It was David Sinclair who convinced me to try Rapamycin. I saw an interview with him where he was asked if he took it. His answer was something like “I tried it, but then I got a cold and I never get colds and this convinced me not to continue.” This seemed way to unscientific of an explanation from someone who is supposed to be a real scientist. I read this as Sinclair secretly does not want people to take Rapamycin. It must run counter to his business interests. So, then I sent an email to Dr Green and signed myself up for Rapamycin.

There was one more data point I should mention. I saw an interview with Brian Kennedy where he was asked about Rapamycin. He very uncomfortably answered that it was the most promising intervention at the time. It was clear that he had a reason not to promote Rapamycin but was not quite able to get himself to lie about it and discourage others from trying. We now know why he avoided the endorsement. He is peddling urolithin, which would be interesting were it not for the existence and easy availability of Rapamycin.

6 Likes