Might as well share my numbers, since I meet those criteria. These are averages from at lest 3 readings, taken over at least 3 month intervals (i.e. each results is a Jan, April, Sept or similar):
Untreated:
LDL-C: 180 mg/dl
HDL-C: 53 mg/dl
Trigs: 70.4 mg/dl
HBA1C: 5.0%
ALT: 42
I have familial hypercholesterolemia, and likely the “hyper absorption” type. As you can see, my trigs were low, HDL-C was good, metabolic health great, but I had some fatty liver and sky high LDL-C.
After treatment with Rosuvastatin 10mg:
LDL-C: 177 mg/dl
HDL-C: 60 mg/dl
Trigs: 67 mg/dl
HBA1C: 5.2%
ALT: 25.0
So for me, the statin alone did very little for LDL-C, but did seem to help with the liver.
Rosuvastatin 5mg, and Ezetimide 5 mg: (half doses of each. Only 1 time for this result):
LDL-C: 93 mg/dl
HDL-C 58 mg/dl
Trigs 59 mg/dl
HBA1C: 5.0%
ALT: didn’t measure
Rosuvastatin 10 mg, and Ezetimibe 10 mg: (using the proper doses)
LDL-C: 71 mg/dl
HDL-C: 45 mg/dl
Trigs: 56 mg/dl
HBA1C: 5.2%
ALT: 31.4
So addition of Ezetimibe was incredibly effective at LDL-C lowering. The 5mg is definitely very effective, but 10 mg is still better. The statin at 10 mg does seem to add 0.2% onto my HBA1C. You can see when I reduced the statin to 5 mg, my A1C went back down again. None of the medications has any measurable negative effects on the liver either. In fact, all the results are better than pre-treatment, and ultrasound showed that a small amount of fatty liver totally resolved once I started treatment.
And for reference, I now use 10 mg Rosu, 10 mg Ezet, and Repatha (injectable PCSK9i):
LDL-C: 43 mg/dl
HDL-C: 58 mg/dl
Trigs: 62 mg/dl
HBA1C: 5.2%
ALT: 28.3
Pretty happy with this. And I totally agree with the others that 5 mg Ezetimibe is very powerful in combination with a statin, and 10 mg gets you some incremental additional benefit. I can’t see any value in going higher. If you want to lower LDL-C more, just add a different drug.