AnUser
#30
Praluent is dosed at 300 mg one time a month.
However 150 mg one time a month reduces LDL cholesterol by 50%
Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study
https://www.ahajournals.org/doi/full/10.1161/JAHA.116.003421
What is the cost of 1x 150 mg autoinjector of praluent?
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KarlT
#31
$500 dollars without insurance.
AnUser
#32
I’m pretty sure that’s two autoinjectors. No difference in price for dose.
On Amazon, price is $1075 for 6 autoinjectors or $179 for one (bought 6 at a time).
scta123
#33
It costs in local pharmacy around 350 eur for two 150 mg pens. Was just getting another thing and asked. I am currently vacationing in Croatia.
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AnUser
#34
It’s not too expensive if 150 mg 1 time a month is enough. If they lower the prices more in the coming years.
I take Repatha. 70 mg twice a month. I split each 140mg inj dose in two using a sterile vial, both to stockpile in case insurance decides to balk-as I have seen w friends on this drug- and also bc my LDLC is 31 and ApoB is 42, good enough for now. Also on Zetia 10mg/night. 48M
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Hi, I read somewhere I think, that if you have issues with normal Statins (muscle pain) and the doctor has tried various options, if you then try a PCSK9 the drug maker would sometimes cover the extra cost?
I’m not sure - part of it is likely the fact that the populations in these countries have much lower earnings on average (GDP per capita): Naturally, few in these countries could afford these drugs at US prices.
GDP per capita: Countries by GDP: The Top 25 Economies in the World
USA: $69,287
Turkey: $9,586
India: $2,277
But, many national healthcare systems (other than the USA) are allowed to negotiate the prices with the Pharma companies, so they negotiate lower costs. These lower prices would may be what are reflected in the sales channels in these countries, though I have no special knowledge of the intersection of national regulations and sales channel pricing in these other countries.
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AnUser
#38
Where did you get $200 price quote in instanbul from? That is even cheaper than 19 000 rupees x 1 on indiamart (near half the price of the medicine in India).
What is the effect of 140 mg Repatha 1 x a month?
Unfortunately I think the price is about $200 per PEN everywhere, meaning it is $400/month from India at two pens a month.
That was posted in the Facebook rapamycin group forum.
AnUser
#40
I found this website on reddit to check for prices: https://www.ilacrehberi.com/
You can type in top right corner the medicine and press enter. Then choose the medicine in the list.
Use barcode number and put it here to see historical prices too: İlaç Fiyatları | 14 Ağustos 2023 tarihli İlaç Fiyat Listesi
Current price for 2 x 140 mg Repatha is 6,865.68TL or 253,29 $
Current price for 1 x 150 mg Praluent is 3,946.69 TL or 145,60 $
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Those are really good prices! Hopefully having it sent would not degrade it too much of these semi summer months. As I said above, I take a half dose every two weeks instead of the full dose with 10 mg per day of Ezetimibe…LDLC is 31 and ApoB is 42, so for me the half dose makes sense, u could do that w Praluent and get it for $150 a month, very doable!!
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Could use some advice for those of you who are more well-versed in this stuff than me.
BACKGROUND: 46yo APOE 3/4 and cardiologist put me on statins for ApoB in the low 100s. Pravastatin didn’t move the needle much, so he put me on rosuvastatin 20mg (which I understand now is a relatively high dose) for last three months. Just got my EmpowerDX results back:
REALLY BAD desmosterol levels! So, looks like I should stop statins entirely, right? Get on ezetimibe and maybe PCSK9? Is there anything I should be doing to bring desmosterol levels up (other than quitting statins)? Thanks so much for any ideas!
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Lower your rosuvastatin dose to 5-10mg and add ezetimibe on top of that instead of quitting it altogether.
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scta123
#44
Seems you are an overabsorber so ezetimbe is the way to go. This should be very effective stand alone therapy in your case. If not consider low dose statin as proposed by @Virilius and possibly PCSK9i or Bempedoic acid as a replacement for statins.
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Yes, I agree. It seems like Ezetimibe would be very beneficial to you.
AnUser
#46
Ezetimibe alone won’t lower apoB enough though, if that is what you mean.
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Ezetimibe seems like a no-brainer, for sure, but worried that it won’t be enough. I suppose I could try it alone for a few months to see what happens before trying to add something like Praluent. Given my very low levels of desmosterol, I don’t think I’m comfortable taking any amount of rosuvastatin.
I previously asked my cardiologist to prescribe a PCSK9 inhibitor and ezetimibe, but he wouldn’t do it. I’m hoping the Boston lab results change his mind, else I guess I’m in the market for a new doctor.
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Why don’t we have massive dose dependent data on hydrophobic Vs lipophilic, Atorvastatin, rosuvastatin 1,2.5,5,10mg etc. And the effect on desmosterol, lathosterol, absorption markers?
Perhaps it is lack of knowledge about desmosterol by cardiologists. My cardiologist did not even know what this was. Crazy.
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