#41

This is a interesting article;

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#42

This too… regarding Colchicine…

Its a serious and rather scary drug in today’s news:

A poison specialist and former medical resident at Mayo Clinic in Minnesota is charged with fatally poisoning his wife, a 32-year-old pharmacist who died days after she went to a hospital in August with stomach distress.

Authorities say Connor Bowman, 30, tried to stop the autopsy on his wife, Betty Bowman - arguing she should be cremated immediately and claiming she had a rare illness, which hospital tests did not confirm. The medical examiner’s office halted the order for cremation, citing suspicious circumstances, according to a criminal complaint, and an autopsy showed Betty Bowman died from toxic effects of colchicine, a medicine used to treat gout.

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#43

thanks @RapAdmin for bringing this to our attention, I might take a pass on Colchicine for now. I’m afraid it might interfere with other longevity substances I’m taking :slight_smile:

#44

Colchicine is deadly if you take too much of it. I thought that was known already?

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#45

When it says in the wikipedia entry “Colchicine has a narrow therapeutic index, so overdosing is a significant risk.” it still sounds somewhat benign. I mean “overdose” could mean a bad reaction of some sort ( I’m not sure of the exact definition of “overdose”)…

and “narrow therapeutic index” doesn’t quite convey that its the drug of choice for poison experts to kill their victims with… which it seems it is.

Anyway - obviously not a drug to play around with.

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#46

I think we need to put this in context. The lethal dose of colchicine according to the CBS article is 0.8mg/kg so for a 60kg adult that’s a dose of 48mg. Low dose colchicine tablets are 0.5mg. How many pharmaceutical drugs would you be willing to take nearly 100x the recommended dose and not expect a potentially fatal result?

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#47

Sorry not for me. I’ll stick with RAPA for now!

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#48

But please don’t take 600mg of Rapa - with or without grapefruit :rofl:

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#49

2mg weekly wit EVOO and GFJ is good for time being. 600mg might make me into superman :joy:

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#50

Yes, I think we should give colchicine a pass… :skull:

#51

What doesn’t kill you makes you stronger :smiley:

#52

Sorry for the slow reply, we’re in the middle of harvest here and finally today got a rain day. Spent it all working on the machine. Not complaining, just explaining.

#53

Living to 120 by decreasing apoB (making sure it never goes above 30-40 mg/dl starting in their 30’s), cancer and neurodegeneration aside.

I like the synergy between Peter and his squire, he asks good questions.

Darren probably helped with the camera work because the picture and lighting look great now.

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#54

They edit out all the pauses. Thanks for saving me time, but it’s not very natural. I’ve noticed he also speeds up the tape for us at times during the weekly podcast. I suppose it helps to waste less time there too.

#55

Background

The lipid hypothesis postulates that lower blood cholesterol is associated with reduced coronary heart disease (CHD) risk, which has been challenged by reports of a U‐shaped relation between cholesterol and death in recent studies. We sought to examine whether the U‐shaped relationship is true and to assess the impact of age on this association.

Conclusions

The cholesterol paradox, for example, higher CHD death in patients with a low cholesterol level, was a reflection of reverse causality, especially among older participants. Our results support the lipid hypothesis that lower blood cholesterol is associated with reduced CHD. Furthermore, the hypothesis remained true when TC was low due to use of statins or other lipid‐lowering medication.

Serum Cholesterol and Impact of Age on Coronary Heart Disease Death in More Than 4 Million Veterans

https://www.ahajournals.org/doi/10.1161/JAHA.123.030496

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