Btw are you taking SGLT2i?
Yup, 6.25mg empagliflozin daily but considering upping it to 25mg a day for weight loss. With my new salary I think I can afford the full dose 
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Is this equivalent to a 25 mg tablet split into quarters? I’ve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control. But I still need to take the plunge. How long have you been taking it? Can you share any pros and cons? the unpredictability of caloric output can be frustrating… #controlfreak 
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Correct.
I’ve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control.
Most of the benefit is seen at the 10mg dose already though the 25mg dose seems to cause increased weight loss so that what I’m considering.
How long have you been taking it?
2 months now.
Can you share any pros and cons?
Pros: I don’t seem to put on much weight anymore despite eating like a pig on weekends.
Contras: at higher doses I crave sugar.
Overall, if it wasn’t for the price, a great drug for kidney protection and weight control. I prefer it over acarbose.
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The high bio-available Curcumin knocked my platelets to below the lower level of the blood test range. It took some figuring but I narrowed it down to the Curcumin I was taking. I stopped the supplement and my platelet level moved back up. Something to be cognizant of. Cheers
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Neo
#106
Which one were you using?
Life Extension - Advanced Curcumin Elite [Life Extension, Advanced Curcumin Elite, Turmeric Extract, Ginger & Turmerones,] This was a few years ago and the product name may have changed. From what I remember it was the Curcumin elite. I was on it 1 a day for nearly 60 days. Cheers
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Bicep
#108
I use a couple tbs of ground flax in my breakfast, used to do the psyllium but I think flax is better now.
I try to get some green every day, but found moringa is tough to grow here. Rabbits love it, it can’t take flame, etc… I’m learning but it’s slow. I think I have only like 4 plants still alive.
I was thinking CLA was the solution for colorectal cancer. A certain one that is made by BB12+Flax oil.
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Bicep
#110
Great article, it looks like they have known for a while that metformin does something to cancer because these guys use it too, and there is a whole pile of studies on it here:
They also use statins for several cancers here, and of course the dewormer mebendazole or fenben.
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Neo
#111
The paper below and summary:
Simple Summary
Metformin, a primary treatment for type 2 diabetes, is known to reduce colorectal cancer (CRC) risk. This study explores the molecular mechanisms behind metformin’s anti-tumour effects in CRC cells. The research identifies specific microRNAs (miRNAs) influenced by metformin, revealing their role in regulating genes associated with cell proliferation and key signalling pathways. The findings provide valuable insights into how metformin disrupts CRC cell growth through post-transcriptional control, impacting both metabolism and cell proliferation.
Abstract
Background: Metformin is a first-line therapy for type 2 diabetes as it disrupts cellular metabolism. Despite the association between metformin and lower cancer incidence, the anti-tumour activity of the drug in colorectal cancer (CRC) is incompletely understood. This study identifies underlying molecular mechanisms by which metformin slows colorectal cancer cell proliferation by investigating metformin-associated microRNA (miRNA) and target gene pairs implicated in signalling pathways. Methods: The present study analysed changes in miRNAs and the coding transcriptome in CRC cells treated with a sublethal dose of metformin, followed by the contextual validation of potential miRNA–target gene pairs. Results: Analyses of small RNA and transcriptome sequencing data revealed 104 miRNAs and 1221 mRNAs to be differentially expressed in CRC cells treated with metformin for 72 h. Interaction networks between differentially expressed miRNAs and putative target mRNAs were identified. Differentially expressed genes were mainly implicated in metabolism and signalling processes, such as the PI3K-Akt and MAPK/ERK pathways. Further validation of potential miRNA–target mRNA pairs revealed that metformin induced miR-2110 and miR-132-3p to target PIK3R3 and, consequently, regulate CRC cell proliferation, cell cycle progression and the PI3K-Akt signalling pathway. Metformin also induced miR-222-3p and miR-589-3p, which directly target STMN1 to inhibit CRC cell proliferation and cell cycle progression. Conclusions: This study identified novel changes in the coding transcriptome and small non-coding RNAs associated with metformin treatment of CRC cells. Integration of these datasets highlighted underlying mechanisms by which metformin impedes cell proliferation in CRC. Importantly, it identified the post-transcriptional regulation of specific genes that impact both metabolism and cell proliferation.
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However, don’t rely on Metformin alone to save you from colon cancer. I take Metformin daily and every 3 years I have a colonoscopy where they remove 2-3 pre-cancerous polyps. Each polyp has a 10% chance of turning into a malignant tumor. Considering I have had 5 colonoscopies and about 8-12 polyps removed, the odds are I’d be in trouble. If I relied on Metformin and didn’t have the colonoscopies, I’d probably be fighting cancer by now or deceased.
If you don’t have polyps, great! Then you don’t need colonoscopies as frequently. If you do, the colonoscopies and polyp removal will save your life. They did for me.
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SNK
#113
when I hear these stories, I’m almost convinced to do a colonoscopy, but then again, I’m like, nah not happening- give me death or give me freedom! 
LaraPo
#114
My former classmate had exactly the same approach until being diagnosed with stage 3 colon cancer. Going through chemo now. Had no signs.
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SNK
#115
I hear you and I guess could happen to anyone, but my bloodline is fortified against cancers. I’d have to go maybe 20 generation/cousins removed to find one that ever had or has cancer. We do however are VERY prone to cardio decease, and as luck has it, I’m doing everything I can to get a heart attack:joy: e.i. for lunch today I had four large egg size balls of Burrata-yummy, and use organic butter very liberally. Oh well, as saying goes we are born once, and will die once so who cares when that happens. If what we/one does makes us die say five times as opposed to once, then I’d be really careful.
Interesting how that works. My ancestors never had a single case of diabetes but instead there are many cases of cardiovascular disease, cancers and alzheimers.
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SNK
#117
Yeah, I find it very interesting also that in our very extended family I literally don’t recall one single person dying of cancer at any age, whereas a lot of them had passed away from heart disease and I currently have 4-5 second cousins with heart problems. Actually, when I think of it in our town of maybe 30,000 people, I don’t recall more than 2-3 cases of people dying of cancer (in last 50 years) and plenty of them passed of heart problems. Also, diabetes not an issue whatsoever, so much so that I don’t have one single person in all my extended friends and family that had or has diabetes. Weird indeed. Maybe we had our bootcamp training against diabetes (while living in communism) when we had nothing else to eat (breakfast, lunch and dinner) but sugar (melted in warm water) and bread. LOL
Alzheimer’s to this day is an unknown disease for us. Never heard of anyone to have had it nor a single one (that I know of) has it now. Some of us might have dementia, but I think we are born with it as opposed to getting it later in life…
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Neo
#118
The issue is that they might just have died of heart disease, etc BEFORE they got cancer if they just would have lived a bit longer.
So if our efforts in health and longevity helps us live past where our relatives would have died of something specific that the family normally died (eg csvd for you, cancer/AD for @Virilius) since a by then you’ll be an aged individual and will hence start to face the exponentially increasing risks of even the things your family did not die of historically.
Your family may not be immune to cancer or @Virilius to diabetes, it’s just that other things could get you earlier
- and those other things with the knowledge here on rapa news you can avoid or at least substantially delay
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