#183

Stoked to see glynac especially since they’ve already done glycine alone

2 Likes
#184

I have a feeling we are going to see a really good result here, as long as they use a high enough dose.

3 Likes
#185

I hope they are measuring such that we can rule out my hypothesis that the effect is just from NAC making the food taste bad resulting in caloric restriction

#187

This 1997 study is probably the strongest evidence
Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice - PubMed (nih.gov)

#188

I have a feeling that we will see similar results to what we saw with astaxanthin, i.e. male median lifespan +12%, male maximum lifespan +6% (not statisticaly significant).

2 Likes
#189

I would like to test Harmine and GLP-1 as antagonists for increased insulin production/ potentially increased Beta Cell regeneration. There was a comment above that the ITP does not test injectables. Rybelsus is a semaglutide in pill form – perhaps that can be used?
Would also like to test Berberine.

1 Like
#190

Oral semaglutide has a super low absorption, that’s why it’s not tested. We need better oral GLP-1RAs and the ITP will test them.

1 Like
#191

Agree we need better oral GLP meds. But to compensate for the poor absorption, Rybelsus pills are dosed far higher than injectables, with the 7 and 14 mg pills supposedly comparable to the two most often prescribed doses of the injectable semaglutide.

1 Like
#192

I know but I think they’re afraid mice could not eat all of that.

1 Like
#193

How about mifepristone? This study showed lifespan extension in fruit flies - and combining with rapamycin, the combination didn’t do better, implying some overlap in their mechanism of action. It’s the drug used for early-stage abortions (combined with another drug), so with the new administration in Washington DC, I wonder if access to the drug might be restricted.

#194

In regard to it being restricted, this is a state issue, not a federal issue. In my state of TN, everything is extremely restricted. Edited per @ng0rge 's wise advice!

1 Like
#195

Careful…that’s a banned word and so are the “other guys”. I think you can still say “Washington, DC”, but we’ll see how @RapAdmin feels tomorrow.

1 Like