HBOT is a HIF 1 alpha thing
2 Likes
From a longevity scientist at the Buck Institute on Aging:
Source: x.com
3 Likes
Apart from the high oxygen under pressure state of HBOT that assists damaged tissue to heal, HBOT is a stress activity for the brain and I believe that is where the magic comes in: when in the chamber,you go from a high oxygen state to a relatively low oxygen state when the 100% oxygen flow is switched off for 5 minutes. This I believe puts a strain on the hypothalamus of the brain which monitors things like blood oxygen concentration and it is the stress of this relative low-oxygen state that probably drives healing processes and stem cell activation.
I believe this is in keeping with other hypothalamic stresses like fasting, sauna, ice bath and high intensity exercise (low oxygen state).
This all still needs to be proven but certainly in HBOT research there is evidence of sirtuin activation in the hypothalamus that is suggestive that it is the hypothalamus that drives the repair.
2 Likes
HBOT is one of the therapies that causes a drop in partial pressure of oxygen from a steady state to a lower state. This does not have to be accompanied by hyperbaric pressures (greater than atmospheric pressures).
It stimulates the HIF 1 alpha response.
It may do other things. Hyperoxia over a period of time can be quite harmful depending upon how high and how long.
I did an analysis on this
3 Likes
are we back to metformin for non diabetes users? I thought Stanfield and the community wasn’t in support
The section of this podcast where they discuss epigenetic measures of aging (bioclocks) is valuable and points to why this paper (mentioned in the first post) is really unhelpful at this time:
3 Likes
KarlT
#27
GOODHART’S LAW: When a measure becomes a target, it ceases to be a good measure.
Biomarkers are easily gamed by pharma treatments that change the # at the expense of hidden risks, e.g. Optimizing:
HbA1c
Hypertension
Cholesterol
Testosterone
Schmokhstsakirfingintfin, etc.
5 Likes
Plus random fluctuations in individual physiology and testing imprecision can lead a person to chase their tail in an effort to “optimize”. …chasing their shadow.
5 Likes
I find it incredibly interesting that in Dr. Salmons experiment with marmosets and Rapamycin, the marmoset median lifespan increased 15% on Rapamycin. However, Steve Horvath tested the epigenetic ages between the control and treated groups and found no difference.
This implies that Rapamycin may not change the epigenetic age although it increases lifespan.
Therefore epigenetic age tests don’t seem useful for determining lifespan if a 15% increase in lifespan doesn’t register on them.
9 Likes
The epigenetic testing has a number of issues. I am not persuaded it provides actionable information.
6 Likes
Agreed about epigenetic tests. This was cristslized for me in the latest Attia roundtable : if I compare the results of a complete metabolic panel with an epigenetic test, which one is more actionable? At least from a clinical POV, these tests are like setting money on fire.
4 Likes
KarlT
#32
These clocks are all for the most part useless. Give it up gang.
6 Likes
AnUser
#33
The people on the leaderboard of Rejuvenation Olympics avoiding taking the tests on bad days is all I need to know about the validity of the current tests.
3 Likes
jnorm
#34
DNA methylation is just one measure of epigenetic age, and there’s no reason to think it’s the ‘best’ one. Even if rapamycin doesn’t appreciably change the dynamics of DNA methylation (still an assumption, as this might only be the case in blood, for example), it might alter epigenetic age according to some other measure (e.g histone modifications, occupancy of nucleosomes or transcription factors, how ‘open’ certain regions of chromatin are, etc).
That said, this is still an area of basic research and acting like the consumer DNA methylation tests have clinical validity is ridiculous.
1 Like
I tried Rapamycin at a low weekly dose. After using 100mgs of it I stopped it because of bad side effects and lipid tests that were not good. I see that Bryan Johnson has stopped taking it. I think that on balance it is harmful and does not slow aging in humans.
I would not necessarily follow what Bryan Johnson does, there are many problems with his rational for stopping rapamycin. I recommend you review this thread… Bryan Johnson stops rapamycin
2 Likes
