#11

That’s how I would expect dapa to work : blunt glucose spikes when they get above a threshold. I’ve had the same experience. I’ve also noticed that I don’t get any glucose lowering when I eat a low carb meal because there is no spike to begin with.

For me, neither metformin nor jardiance 7.5mg helped lower my A1c, which is in the pre diabetic range. This could be because I’m already eating low carb, but that’s just my guess. The jury is still out on tirzepatide, but I should know soon with my annual tests.

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#12

My HbA1C has always been in the normal range, but I’d like to lower it further. I believe the combination of a GLP-1/GIP receptor agonist and an SGLT2 inhibitor can be effective for most people. Hopefully, I and others can replicate the success of cl-user. I have a test coming up soon, so I’m looking forward to seeing the results

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#13

I was on metformin for a few years and it only had a slight effect on my glucose spikes according to my cgm.

My tiny doses of glp1 don’t do anything I can tell, but that is expected.

Dapagliflozin has made a tremendous difference. I’ll still break through 140 once per day a few times per week, but now it’s only once and it never goes a lot higher (to 170+). My CGM used to look like a rollercoaster. FWIW, these results are with mostly my diet of beans, berries, veggies and not eating bread, oats, rice etc. I recently tried having steel cut oats again now that my spikes are managed so well, but nope, that still sent my numbers soaring, just not as bad.

@qBx123Yk Yes, I’ve noticed no matter what I do, my glucose upon waking is always similar, medication or not. I was hoping it would lower because I live close to 100.

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#14

Glad to hear you’re getting great results from dapagliflozin! I’ve had the same experience with oats. I always heard they were slow-digesting and provided “all-day energy,” but my glucose spikes tell a different story.

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#15

Did you ever have a fasting insulin test? HBA1C is not a precise test. If your RBCs live a little longer (which is not uncommon in low carb diets) you would have an artificially high Hba1c.

#16

I don’t know who you are replying to but I posted the fasted insulin plot in the first post.

#17

I just did that DEXA and it’s pretty cool!
3mg/week of Tirzepatide + exercise reduced my fat (from 18.3% to 14.3%) but increased the lean body mass from 78% to 82%.

image
image1649×389 78.7 KB

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#18

This blog and video explains 16 potential causes of Insulin Resistance. Mario Kratz is an unbiased researcher

#19

This appears to be the case with me as well. Despite incorporating gym workouts + HIIT (and no change to any other variables), my hba1c bumped up from 5.2% to 5.8%, having taken rosuvastatin 5mg/day for 4 weeks in a row… I suspect this could be an amplified response in a highly insulin sensitive individual like me, with Fasting Insulin 2 and Fasting Glucose 90)… In general, Rosuvastatin appears to have a dose-dependent effect on glucose metabolism for the average population (although some people don’t seem to have any/much side effect even at large dose), however, for some people, even a low dose appears to significantly impair glucose homeostatis.

Fortunately for me, Bempedoic Acid + Ezetibime has no impact on my glucose metabolism, liver function and renal function. With Rosuvastatin 5mg + Bempedoic Acid 180mg + Ezetibime 10mg, I can get my LDLc down to <60 mg/dL (while coping up glucose dysregulation). With only Bempedoic Acid 180mg + Ezetibime 10mg, I can get my LDLc down to about 77 mg/dL, I may have to settle for this. Pcsk9i is neither easily accesible nor afforable, but i’ll be keen to do an experiment on it some day… And I haven’t tried Pitavastatin, which appears to have the most neutral effect on glucose metabolism

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#20

You can try adding a low-dose statin every other day (EOD). I find that acceptable in my case where atorvastatin every day was causing muscle spasms. Rosuvastatin was far worse.

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#21

Sure… Will try that (every other day approach)… As I recall, in the past, I used to alternate between Rosuvastatin and Bempedoic/Ezetemibe, and my hba1c was probably fine then… Will need to test and confirm this

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#22

Do you take Rapamycin? I’ve have some bizarre increases in A1C a couple of instances when I was taking weekly (usually 5mg) Rapamycin doses. I’ve had to take a little break and then get back on it but now every two weeks. I don’t know what else could explain the increases.

#23

That or one of the statins for more sensitive people like pitavastatin/fluvastatin/pravastatin which each boast very low rates of myalga compared to other statins, especially at low doses.

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#24

Yeah, this is quite possible. Yes, i do take rapa 5mg/weekly. In the recent past (last year), it didn’t seem to impact my glucose levels, but I need to check again… I’ll consider switching to once in 2 weeks, or take a break for 1-2 months, and see what the difference is

#25

Yea I’m just speculating here but I’ve been taking 5mg rosuvastatin a while now with many blood tests and I don’t seem to notice much of a spike in A1C, so I’m thinking it could be the Rapamycin since I’ve heard similar stories about it raising A1C. I wish I could tell you for sure.

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#26

I got a test back of HbA1c 4.9
Is that good? Or too low? Is there such a thing as too low?

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#27

That’s a good value. If you go near the 4.0 mark you are entering hypoglycemia territory which is too low.

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#28

4.9 is excellent. Keep doing whatever it is you are doing.

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#29

Yes. 4.9 is where you want to be. You can even go up to 5.0-1 and still be doing well. The lower you go, the more effects of hypoglycemia you might feel.

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#30

I have a bit of wiggle room to eat more then.