#8

I don’t even know how many patients gethealthspan has. My thinking is that there are a lot of people that would be willing to try something new (drug or therapy) if it had to do with Healthspan and longevity, especially a drug that is known to be pretty safe and has a long history of being prescribed to transplant patients with few effects. In last six months I have had literally three random people talk about RAPA . If so many people are made aware of it, I think it is safe that afew of them are already trying it, but 20,000 in 330 Million population is nothing. When New York times and many other publications have already written about it you must know there is a lot of people already using it. Just the way it works IMO

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#9

Interesting. I’m a physician and I’ve never had anyone bring up Rapamycin with me.

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#10

I saw peter attia talk about it on Joe Rogan maybe 3 or 4 years ago, mentioned it to my doctor and he said sure. Gave me a prescription that day. He has no other patients that take it, he doesn’t take it. My family and friends know I take it, don’t want to anyway for various reasons.

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#11

Interesting but it depends on the doctor-patient relationship. I don’t know you but if you are the type of doctor that is very formal a lot of people will feel intimidated to ask things out of the issue at hand. Just saying. One of the three people btw was my sister (she asked me about it out of the blue one day) but I didn’t tell her I’m using it because she has some other health issues and was afraid it might negatively affect her. I just told her it is something I’m watching but I need more info before I dive into it.

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#12

I have spoken to pretty my much every doctor I have met about it. None would prescribe it, none had prescribed it. Of my 30 closest friends, I have shared I am taking it, shared info on it, and maybe 5 are taking rapamycin. But it is changing with the increase in news coverage.

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#13

I agree, I’m yet to see a patient in the ER who indicates they are on rapamycin for longevity. I only have seen it in transplant patients, primarily kidney transplants. It should be more common, and there is the factor that I’d not report it if I were checking into the ER unless it was an infectious issue and I was under significant mTORC1 inhibition at the time of being seen. Otherwise, I’d not mention it as it would be irrelevant to my care and evaluation, and would just confuse the physician seeing me to go down stupid rabbit holes based on this, not understanding cyclic use of rapamycin.

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#14

Exactly! I haven’t told my physician during the last two years that I’ve been taking it, luckily haven’t had to go to the ER either. Actually have only interacted with him 1x during this period, which was to renew my HRT topical estrogen prescription.

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#16

I find it interesting how you can look at interest in rapamycin has grown over time. I was just looking at Google Trends and realized it also is a good way to look that the rapidly growing interest in rapamycin.

You can try yourself: https://trends.google.com/trends/explore?date=today%205-y&geo=US&q=rapamycin,altos%20labs&hl=en

I looked at the growth of interest in rapamycin over the past 5 years, and thought I’d compare it to the biggest news in the longevity field over the past few years, the launch of Altos labs. While Altos has gotten some interest at points in time (like when it was launched), it obviously hasn’t captured peoples interest like rapamycin has (at least so far).

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The only other compound/chemical that I could think of that has gotten similar levels of interest as rapamycin is likely resveratrol; so I compared it too. I was surprised how high the level of interest in resveratrol is, years after its been debunked. Its amazing the staying power of false information in the public’s mind once it gets out there…

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#17

Is it really growing? I feel like I see the same users here talking, and if Rapamycin was growing you’d see a lot more users here. You even got a backlink from the NYT. It looks like there were about 200 new users (+5%) the past month but barely anyone new is posting. I remember previously there were mostly only activity in the cardiovascular thread, and maybe a bit in the Bryan Johnson thread, so activity has increased for sure. It’s a bit boring honestly, not that much new good content, a lot of opinions and speculation though, maybe it’ll change or maybe not. It might be chutzpah, but I feel like I don’t learn anything here anymore, outside of many @adssx posts and when @Neo is talking. It’s also so much activity to comb through just to find their posts, and when you click on a new post you just see someone’s random opinion as if someone cares, annoying. It would be cool if they got their chatroom somewhere else. There’s something bad about sorting about new activity.

It’s more like a place for people to pee and mark their territory rather than share studies and science. I shouldn’t complain, it seems people like it. Keep clicking on new posts and reading someone’s opinion! I’m sure it’ll get better or maybe some new formatting of threads and posts…

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#18

We can’t have more new content here than what is published by academia. And the truth is that you summed up very well what we already know about longevity interventions in this thread: Easy Hacks Guide Targeting Different Biomarkers (BMI, apoB, blood pressure, HbA1c, eGFR, etc) I learned a lot during the last 12 months reading this forum, but at the end of the day what I learned is basically what is in that thread :slight_smile:

The rest is, as you say, just speculations. And n=1 anecdotes (that can still be useful btw). And people arguing. That’s fine.

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#19

I guess there’s just so much basic stuff, not enough Health, Longevity, and Happiness Acceleration. But I don’t know. It is how it is.

sp

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#20

Sometimes we have to wait for the science. It usually comes in bursts. Right now seems like a lull in the research.

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#21

Lustgarten’s videos are an example of continously new content. I’ll pay more attention to him and Bryan Johnson I guess, and anyone else in the future who brings a lot of data and studies.

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#22

This is a good attempt (thank you!); the problem I see with it is that there is a high probability of double-counting: people who initially got a script from one doctor and moved to another, or to an online pill mill telemedicine platform, or to importation from offshore — and every alternative permutation of sequence.

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#23

Double counting is a potential issue. I haven’t polled people on whether they have switched doctors or shifted where they get their prescriptions over time.

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#24

Brian Kennedy estimates up to 100,000 people could be taking rapamycin off label now (in this new video): https://www.youtube.com/watch?v=z4AeCkD2650

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#25

Sounds like Brian Kennedy is positive on rapamycin here. Wonder if he is taking it himself. He also seems to be on NAD supplements.

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#26

That seems unlikely to me, since the Rapamycin thread for buying rapamycin has 137,000 views and that’s includes people who are curious or view it multiple times, not people who take it regularly.

I’d guess it’s like 30% of the registered users here, which is 1433, add a couple of thousand users and it’s maybe 5,000 users in total who use it regularly. That’s also a third of Matt Kaeberlein’s subscribers.

I might be scribbling patterns in the sand looking at astrology signs here, but

100,000 feels way too high.

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#27

FWIW, I have been repeatedly surprised by how many of my friends and even casual acquaintances admit to using rapamycin. Just the other week, I had a brief conversation with a casual acquaintance in the park where I jog - he goes there to walk his dog. Years ago, as an animal lover, I have struck an aquaintence with him based on that dog. Last week he was sharing his worries about the health of the elderly dog. I cautiously ventured that there is this drug, rapamycin which has been shown in dogs to… before I could finish the sentence, he knew all about it, and informed me that in fact he is taking rapamycin himself! And so we had a brief exchange about rapamycin in humans, effects on exercise and so on, lol. Importantly, he was not aware of rapamycin news website, so I don’t think it’s safe to assume most rapa users frequent this place.

I swear this happens so often with random people in random situations, that I started to ponder the meaning of the little factoid Matt Kaeberlein shared in one of his podcasts, that the nickname for rapamycin among those in the know, is “vitamin R”. Hmm, perhaps rapamycin is headed for the frequency of use of common vitamins taken by masses of people in everyday life. Something we laugh about with my wife after learning that yet another person transpires to be a rapa user… it’s just another vitamin to people these days, lol!

Of course, I might be living in a bubble here in West Hollywood, but I’ve had these encounters elsewhere too.

All anecdotal of course, but I feel the rapa cat is well out of the bag, and scratching. This didn’t use to happen as often even a couple of years ago, but I feel rapa has now reached a critical mass and soon it’ll be old hat. The 100K number feels plausible to me, if not an undercount, to be honest. But who knows…

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#28

I tend to agree with @AnUser: 100k seemed way too high to me. But, like @CronosTempi, I had two recent encounters (one in the South of France and one in Dubai) with people in their 30s taking rapa. They only mentioned it when we started to discuss health and longevity. They’re not active on this forum, although I’m sure they read some posts here before making the decision to start it.

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