#68

Please do! What parts of your body would you use this on? I think Brian Johnson does it all over his body (please correct me if I’m wrong on this).

At a price of only $1600, this would seem to be a very good financial investment if it works well, and you use it consistently over time.

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#69

@RapAdmin, as far as I understand, Tixel is primarily meant to be used for the face, neck, and décolleté + problem areas at body. Treating the face only will require 300-500 pulses, and the aforementioned areas together will need about 1000 pulses. Handling the entire body with Tixel would be challenging, and I have not seen any reports or studies on whole body treatments. The original Tixel device has two handles: one for the face and one dedicated to the periorbital area (smaller surface). The OEM version has one or two handles; the second option includes an additional handle for the body, which costs an extra $400-500 (I have decided for one handle version mainly because of price). As far as I understand, the body handle is meant to be used mainly for problem areas like scars…

Economics of the machine: One original handle can handle 500,000 pulses, but everything above 25,000 should be acquired from the producer. The OEM handle has a limit of 50,000 pulses. So, in fact, you are purchasing 50-100+ Tixel procedures with the OEM machine, which is still a good choice, considering that a single procedure costs around $400-500 at a cosmetic salon.

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#70

There appear to be slightly differing opinions on that…

This therapy is ideal for the delicate skin on the eyes, face, neck, chest, and hands.

Source: https://www.bellasanteclinic.com/tixel

Tixel is suitable for treating fine lines, wrinkles, sun damage, age spots, active acne, acne scars, pore size, lip lines, forehead lines, crepey skin on the eyelids, crow’s feet and neck folds among others. Body parts such as abdomen, knees and arms also get great results

Source: Med Spa - Tixel Skin Resurfacing – Estetica Spa

Seems like it could be used anywhere you want to tighten skin or improve skin health or “quality”.

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#71

This seems like something that a few friends could get together to purchase and then pass the device around between them, perhaps every month.

At $1600 to $2000 per device it would only be approximately, $500 to $700 per person.

Talk to your friends… And report back your results…

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#72

Thanks so much for sharing : I pulled the trigger on mine as well ( from Alibaba ) but to reduce costs I asked oversea shipping so will only arrive end of June or beginning July : since am away travelling for the moment I will look further into it again the next weeks but very much looking forward to your updates and will obviously do the same . I have another appointment when am back with the doctor who did the first treatment on me to see results after 8 weeks ( with professional fotos, my cell phone pictures are not clear enough ) but I can see improvements myself already (on one side of my mouth the lines practically seem to have disappeared when I look in the mirror ; on the other side - with more lines-, result is less spectacular/ visible). But curious to see the doctor’s precise pictures in a couple of weeks.

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#73

Great, look forward to your experience! I will experiment with pushing the neocollagenesis from inside and outside on a certain day: Tixel procedure, + activate MTOR before the procedure to push the building of new collagen (Efficient Combination of Longevity Strategies - #32 by SilentWatcher) (but no workout after tixel), + support the neocollagenesis with supplementation of collagen peptides / hyaluron / ceramides and apply mesotherapy complex on open channels → having inside/outside triggers (holistic approach). Will share experience.

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#74

I still have not received my machine but went today to get some professional “ after” pictures taken and the difference with the “ before” pictures was visible ( and should still improve I was told in the next 2 months).

Results are not dramatic but good enough to wanting to repeat: best visible results are around eyes and neck wrinkles ; but overall, all wrinkles, pores and skin quality improved. unfortunately the quality of my mobile pictures diminished the visibility of the results so I d rather not attach them
( still if someone wants to see them just ask and I can send them privately).

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#75

Are you just seeing reduction in wrinkles or have you noticed any skin tightening?

#76

I particularly noticed constant skin tightening in the weeks afterwards ( as if I had constantly a mask on that tightened the skin) am not sure if I got used to it and that it is still there , or whether it decreased . From what I was told and read it is probably still there but one gets used to it ?

Anyway am pleased with the results and look forward to seeing results after a next session ( just hope I will be able to do it on myself without accidents :sweat_smile::crossed_fingers:)

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#77

Yes. Always hard to tell I think. Good luck. I’ve been planning on doing it, but have a have 2 and a half hour drive to find a clinic that doesn’t charge an arm and an exorbitant amount.

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#78

Recent studies on Tixel use for skin improvement:

The Efficacy of Thermal Mechanical Fractional Injury System for Facial Rejuvenation: Subjective, Objective and Image Analysis Study

J Cosmet Dermatol. 2025 Feb;24(2):e70063. doi: 10.1111/jocd.70063. (Open Access)

Background: Facial aging is the result of a number of factors, including the resorption of skeletal tissue, the atrophy of fat pads, and the laxity of connective tissue. These factors contribute to a reduction in facial volume and the development of skin changes. Thermal mechanical fractional injury (TMFI) represents a minimally invasive solution, stimulating collagen production and enhancing the delivery of topical formulations via epidermal microcraters.

Aim: This study seeks to evaluate the effects of TMFI on skin quality and introduce quantifiable methods to assess improvements.

Patients and methods: Adult patients seeking facial rejuvenation underwent three TMFI sessions, with a one-month interval between each session. The assessment of skin quality was conducted using the Scientific Assessment Scale of Skin Quality (SASSQ), which was completed by blinded experts. Patient satisfaction was evaluated using the FACEQ scale. Additionally, objective texture analysis was performed using the MAZDA program, which quantified surface irregularities.

Results: The objective assessments demonstrated statistically significant improvements in the following parameters: roughness, wrinkles, pore size, elasticity, pigmentation, and erythema (p < 0.001). The FACE-Q results demonstrated high patient satisfaction, with a response rate of 68.4%. The MAZDA analysis confirmed significant texture improvements across most facial zones, with the exception of the medial forehead.

Conclusions: The findings of this study indicate that TMFI is an effective intervention for improving skin quality in a diverse range of patients. This study contributes to the existing literature on TMFI, which supports its use as a valuable tool in the field of skin rejuvenation.

Clinical Efficacy and Safety of a Thermomechanical Fractional Injury Device for Neck Rejuvenation

Abstract

Background: Neck rejuvenation has consistently become a popular cosmetic procedure. While various treatment modalities have been used, a novel fractional thermomechanical skin rejuvenation system was recently developed to create dermal coagulation through direct heat transfer with subsequent neocollagenesis.

Objective: A prospective clinical trial evaluated the efficacy and safety of a thermomechanical fractional injury device (Tixel 2, Novoxel, Netanya, Israel) for neck rhytides.

Materials and methods: Subjects with moderate to severe neck rhytides were enrolled for 4 monthly treatments.

Results: Twenty-six subjects were enrolled and completed all study visits. The mean age was 58.4 years, and 100.0% were women. Fitzpatrick skin types I to IV were included. For Fitzpatrick Wrinkle Classification System (FWCS), the mean baseline score was 6.3. As per investigator, there was a mean 1.5-grade improvement in FWCS at 1-month follow-up ( p < .00001) and 1.4-grade improvement in FWCS at 3-month follow-up ( p < .00001). For physician Global Aesthetic Improvement Scale, all subjects (100%) had improvement at both 1- and 3-month follow-up visits. There were no severe adverse events, and subjects experienced minimal pain.

Conclusion: A novel thermomechanical fractional injury device is effective and safe for the treatment of neck rhytides.

Comprehensive Review of Thermomechanical Fractional Injury Device: Applications in Medical and Cosmetic Dermatology

Objective: Our aim was to review the current and emerging dermatological applications of the novel thermomechanical fractional injury (TMFI) device, Tixel® (Novoxel, Netanya, Israel).

Methods: A systematic review of PubMed using the search terms of “Tixel”, “thermomechanical fractional”, [“thermomechanical ablation” and “skin”], and [“thermomechanical ablation” and “dermatology”].

Results: Thirty-six articles matched our inquiry. Fifteen articles did not meet inclusion criteria. Of the remaining 21 articles, eight were related to device-assisted drug delivery, seven related to photoaging, and seven related to scientific/ preclinical exploration. Preclinical studies have shown ablative and non-ablative microchannel formation similar to that of CO₂ laser but without charring, with clinical studies demonstrating efficacy for a wide range of applications including rhytides, hypertrophic scarring, infantile hemangiomas, and acne/rosacea. The treatment is well tolerated with minimal discomfort and downtime, showing promise for pain-averse and pediatric populations. Few adverse events have been reported, with a high degree of safety demonstrated in all Fitzpatrick types.

Limitations: Heterogeneous result reporting among studies. Limited number of randomized controlled trials.

Conclusion: Tixel® is an emerging TMFI device with a wide range of current and potential applications, including device-assisted drug delivery and treatment of rhytides, photoaging, and scars among other conditions. The device has both ablative and non-ablative settings and has been safely used in all Fitzpatrick skin types. Larger and randomized controlled trials are needed to compare this device to current standard of care treatments.

and

Retrospective study on the safety and tolerability of clinical treatments with a novel Thermomechanical Ablation device on 150 patients

Introduction: There are currently not many publications on the safety of thermomechanical ablation (TMA) devices, and those that are published only have small numbers of subjects. This treatment is gaining popularity in Europe and Asia, and thus there is a need to look at the safety of this treatment.

Objective: The purpose of this retrospective study was to evaluate the safety of the clinical use of the novel TMA system (Tixel, Novoxel, Israel) for facial rejuvenation and treatment of acne scars.

Methods: We did a retrospective review of our first 150 patients who were treated with the TMA device.

Results: One hundred and fifty consecutive patients aged 20 years to 82 years with Fitzpatrick skin types I to V treated with the TMA device were included in this study. The total number of treatment sessions was 327 (average 2.18 treatment per patient). The total number of pulses delivered to these patients was 1 48 856 (average 455 pulses per session). The indications for the treatment were photodamaged skin (n=145) and acne scarring (n=5). All patients were able to use makeup immediately after the treatment at lower settings, thus needing no real recovery time. Patients treated at higher settings were able to use makeup after 2 days. There were four reported complications: post-inflammatory hyperpigmentation (n=2), impetigo (n=1), and dermatitis (n=1).

Conclusions: Using the TMA device in the treatment of photodamage and acne scarring is safe in skin types I to V and has a low incidence of temporary side effects with no permanent side effects.

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#79

Have you ever had a Tixel treatment?

#80

Not me. All I know is what I have read here. Others here have positive results.

#81

Not me either. There has to be a reason to use it and I still have a pretty good skin at 70 which surprises even me bc everyone I know who are my age are not that lucky. I still think it’s diet or could be rapamycin. Wondering when Im going to see real changes. At 75 maybe? :grinning:

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#82

I keep thinking: if Tixel is really just about raising the temp of the skin enough to force it to re-heal but not enough to burn, why couldn’t one accomplish this at home with, say, a hot washcloth and 20 minutes? :stuck_out_tongue_winking_eye:

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#83

From the looks of it (given my cursory review of the literature) it seems much closer to the common laser skin treatment approaches (fractional laser) with micro-injuries to stimulate collagen growth… so hot wash clothes won’t do it…

Study design/materials and methods: Six female participants were treated with Tixel© on healthy skin of the dorsal side of the right forearm in a single session with a 600 µm protrusion and 12 milliseconds pulse. The treated area was examined with confocal laser scanning microscopy on day 1, 2, 7, and 14 after treatment. Clinical symptoms were evaluated at the same time-points.

Results: All patients developed erythema and mild edema on the treated areas, which completely disappeared within 14 days. No post-inflammatory hyperpigmentation or scarring was observed. Thermomechanical skin ablation resulted in the formation of homogeneous micro-ablation zones. Two weeks after ablation, the honeycomb patterns of the epidermis in all examined layers was thoroughly restored. Thus, wound-healing was completed.

Conclusions: Wound healing after thermomechanical skin ablation is much faster compared with other fractionated ablation methods. Treatment intervals of 2-4 weeks could be recommended. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.

and

Comprehensive Review of Thermomechanical Fractional Injury Device: Applications in Medical and Cosmetic Dermatology

Methods: A systematic review of PubMed using the search terms of “Tixel”, “thermomechanical fractional”, [“thermomechanical ablation” and “skin”], and [“thermomechanical ablation” and “dermatology”].

Results: Thirty-six articles matched our inquiry. Fifteen articles did not meet inclusion criteria. Of the remaining 21 articles, eight were related to device-assisted drug delivery, seven related to photoaging, and seven related to scientific/ preclinical exploration. Preclinical studies have shown ablative and non-ablative microchannel formation similar to that of CO₂ laser but without charring, with clinical studies demonstrating efficacy for a wide range of applications including rhytides, hypertrophic scarring, infantile hemangiomas, and acne/rosacea. The treatment is well tolerated with minimal discomfort and downtime, showing promise for pain-averse and pediatric populations. Few adverse events have been reported, with a high degree of safety demonstrated in all Fitzpatrick types.

Limitations: Heterogeneous result reporting among studies. Limited number of randomized controlled trials.

Conclusion: Tixel® is an emerging TMFI device with a wide range of current and potential applications, including device-assisted drug delivery and treatment of rhytides, photoaging, and scars among other conditions. The device has both ablative and non-ablative settings and has been safely used in all Fitzpatrick skin types. Larger and randomized controlled trials are needed to compare this device to current standard of care treatments.

1 Like
#84

And now for something completely different (and unanticipated)… found this as I was researching Tixel on Pubmed:

Treatment of port wine stain with Tixel-induced rapamycin delivery following pulsed dye laser application

Although pulsed dye laser (PDL) is considered the gold standard treatment for port wine stains (PWS), post PDL revascularization is one of the main causes of incomplete regression and recurrence. Recently, topical sirolimus have been shown to improve treatment outcome probably through minimizing post-laser revascularization. We sought to evaluate the added value of the Tixel drug delivery system (DDS) to the PDL and topical rapamycin treatment for PWS. This case series includes three teenager patients with previously treated PWS with PDL. Upon enrollment, every stain was divided into A and B halves for treatment assignments to the following regimens: (A) PDL + DDS + rapamycin; (B) PDL + rapamycin. Subjects were instructed to apply rapamycin topically over the PWS twice daily for the entire treatment period. Assessment of the treatment and adverse reactions as well as photographs was performed at baseline and before every PDL treatment. There were clinically significant differences in blanching responses favoring PWS receiving PDL + DDS + rapamycin as compared to PDL + rapamycin alone. Transient hyperpigmentation was noted in one patient. Two patients developed mild transient irritation and dermatitis following the treatment on both halves. The use of drug delivery system combined with topical rapamycin has no remarkable adverse effects, improves the results of PDL treatment for port wine stains, and can reduce the total number of required PDL sessions.

and

So, perhaps we can improve skin response (anti-aging effects) combining rapamycin with Tixel.

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#85

Dermoelectroporation would be superior to Tixel for the transdermal delivery part. Just sayin. :wink:

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#86

2 posts were merged into an existing topic: Dermoelectroporation for Aging Skin Health

#87

The “secret sauce” behind ­Tixel® is its tiny titanium tip that’s flash-heated to ≈ 400 °C (don’t think you will manage that with washcloth). The tip only touches the skin for 4-10 ms, but in that split-second it evaporates micro-columns in the stratum corneum without burning deeper tissue. Those micro-channels stay open for hours, giving topicals a direct highway into the viable epidermis and upper dermis:

  • Hydrophilic actives such as verapamil, diclofenac and vitamin C (lab work showed up-to-ten-fold penetration boosts).
  • Peptides & proteins – the standout example is topical botulinum-toxin A (“BoNT-A”) for rosacea flushing or peri-orbital lines;
  • Rapamycin, ALA, corticosteroids, growth factors, and other compounds
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