Top 5 - Which Currently Available Longevity Interventions Do You Think Are the Best

[CronosTempi]

Thank you. And remember, don’t count words, make sure the words count.

[Bicep]

You’re a good writer and I enjoy reading. Also your enthusiasm is good. In the long run I’m not sure interventions are good.

I think obesity and alcoholism and things of that nature should be bred out. Taking injections daily or weekly is crazy. Over time we can get better solutions maybe, with understanding. Certainly it’s important to understand that cross breeding and maintaining institutions to properly prepare the next generation is more important. This way we maintain the ability to adapt long term. The world is changing and our inputs are changing already faster than our bodies are. If the rate of change slows down even more that could be bad.

I see some value in keeping geezers healthy till they go. I’m not sure we should hang around too long.

[Pat25]

The hesitation I have about those very wordy texts that, it’s my humble impression, say the same thing ~10-20 times in different words, is that I start to wonder what if ultimately Rapa were to give me an extra year of life, and what if I ultimately spent that time reading on this forum.
More in general someone mentioned taking time off of the forum, and that’s also what I commonly do. But still it would be easier if it were possible to somehow have a better oversight of posts that really matter to individual readers.

[Pat25]

@CronosTempi

Somehow you imagine that your anti-polypharmacy stance is novel or informative.

Just like you accused another member in a lengthy post of something he certainly hadn’t said/written (to ‘not take any medication’); you now accuse me of something I have certainly never written or suggested. The rest of that lengthy post aside, I much agree with your suggestion to ‘leave it at this’.

[CronosTempi]

I apologize for my wrong assumption (not accusation!) of the purpose of your posts. I assumed that, you, like I, only post what is either novel or informative. I may fail somtimes (or often!) to be sufficiently informative, but it is always my sole intent, perhaps imperfectly accomplished. Isn’t that the purpose of this site, what other reason would there be to post, unless it’s novel, informative or both? I didn’t realize that you DID NOT intend for your posts to be either novel or informative, and in fact take that as an accusation that I’d even presume to imagine that that was your intent. My bad.

I am however glad that we have reached some point of agreement: this subject should be dropped. Peace!

[LaraPo]

Just recently I ran out of my melatonin supply, then forgot to re-order, and couple weeks later realized that my sleep without melatonin is exactly the same as with it. 7-8 hours, with I interruption around 6 am. So, do I really need it?

[John_Hemming]

Melatonin does more than just handle sleep processes.

[Joseph_Lavelle]

I’m up to 10mg of melatonin at night (when I get up to use bathroom). I’m still a bit extra groggy in the AM….hoping that fades.

[Virilius]

@Bicep

I think obesity and alcoholism and things of that nature should be bred out. Taking injections daily or weekly is crazy.

I don’t think this is an eugenics forum? If interventions help us overcome our natural instinct of overeating when possible that is desirable.

I see some value in keeping geezers healthy till they go. I’m not sure we should hang around too long.

From a purely eugenistic point of view, what is the point in keeping pensioners around?

[Bicep]

I’m not in favor of ever telling people what to do, so eugenics are out. I just think naturally people that are healthier should thrive and eventually optimum should come. If we lengthen lives and have fewer babies, then it will take much longer to naturally adapt.

The solution may not be obvious to us, so I would not put anybody from the government in charge of any of this.

[AnUser]

Immortality is rejecting a lot of evolutionary change over time either way and adapting with medications, non-somatic gene therapy (not passed on), etc.

[Virilius]

@Bicep

I just think naturally people that are healthier should thrive and eventually optimum should come.

Why not use therapies to make people “perfect” instead of relying on perfect people breeding? Besides, the uber-educated urbanite has a <1.0 fertility rate while some religious farmer has 8 children by age 36.

[ng0rge]

@Pat25

I start to wonder what if ultimately Rapa were to give me an extra year of life, and what if I ultimately spent that time reading on this forum.

Good point! So I might gain an extra year of life if I just got off this damn forum…I guess I’m hoping that it’s a form of brain exercise that might help and occasionally I gain a little info or entertainment… and I can throw in my 2 cents…so it’s kinda like a social engagement mimetic. That’s good, right? Otherwise I’d be down at the pub. Although it’s true that conversation here does occasionally descend into the equivalent of a drunken rant, at least it’s easy to skim over that if you’re not in the mood. I’m glad we have the freedom to ramble a bit (you don’t have to read it) and you get to see a lot of different personality types (sometimes incomprehensible…ahem…@AnUser and @Virilius ) but it should be all in good fun…we’re certainly not here for the stress.
***by the way @CronosTempi you might consider a little softer approach, a little less quick to take offense.

[sunshine4]

Its not just about sleep, some/many (?) believe it to be highly anti-cancer and heart disease and beneficial to a lot of disease processes. Though I understand the arguments that supplemental melatonin might not be beneficial

I just googled melatonin heart disease and the first thing I got back was this article referencing studies Melatonin’s role in protecting the heart – the evidence so far.

Given that heart disease is the leading cause of death in the world, killing around 17.9 million people each year, this action is of particular interest to researchers.

Research shows that people with cardiovascular disease have lower levels of melatonin in their blood compared with healthy people. And there is a strong inverse relationship between melatonin levels and cardiovascular disease. In other words, the lower a person’s melatonin level, the higher their risk of cardiovascular disease.

and some feel its highly anti-cancer. In the glycine is an mtor1 activator thread about colon cancer a user named JuanDaw posting this study Nutrients | Free Full-Text | Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis

3.3. Change in Tumor Volume

We observed an 8.7% (−17.5; 40.9) increased tumor volume in the control group and a 63.2% (−3.1; 71.1) decreased tumor volume in melatonin, 43% (−12.6; 70.1) in glycine, and 47.7% (−116.9; 60.6) in combined supplementation with melatonin and glycine at day 8 vs. day 14.

Now there are arguments about exogenous and endogenous melatonin and the differences, synthetic or not, and other issues concerning melatonin. Some people feel taking the supplemental melatonin disrupts the body’s natural processes, so its only guesswork I guess that supplemental melatonin is great

[desertshores]

As pointed out in this and other threads, taking melatonin has several benefits. I think it is especially true for women.

N=1: My daughter takes 20 mg/daily and says it dramatically reduces PMS and cramps.

There seems to be an increasing amount of evidence that melatonin might reduce the risk of breast cancer.

Melatonin: an inhibitor of breast cancer. (Endocrine-related cancer, 2015)
Melatonin: A Potential Therapeutic Option for Breast Cancer. (Trends in endocrinology and metabolism: TEM, 2020)
Melatonin and breast cancer: Evidences from preclinical and human studies. (Critical reviews in oncology/hematology, 2018)
The Intricate Relationship between Melatonin and Breast Cancer: A Short Review. (Chirurgia (Bucharest, Romania : 1990), 2021)
Melatonin, an inhibitory agent in breast cancer. (Breast cancer (Tokyo, Japan), 2017)
Protective role of melatonin in breast cancer: what we can learn from women with blindness. (Cancer causes & control : CCC, 2022)
Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms. (Journal of cellular biochemistry, 2019)
Melatonin: A Potential Antineoplastic Agent in Breast Cancer. (Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2022)
Circadian Rhythm and Concentration of Melatonin in Breast Cancer Patients. (Endocrine, metabolic & immune disorders drug targets, 2021)
Breast cancer cells: Modulation by melatonin and the ubiquitin-proteasome system–a review. (Molecular and cellular endocrinology, 2015)

[Bicep]

You might really enjoy “Idiocracy”. It’s a classic.

[RapAdmin]

I saw @Boldi 's post in the Rapamycin Facebook group today (I don’t check there too much, but found this interesting). He’s still using 17AE and I like his approach to improve absorption. I think I may try this approach this year:

[Boldi]

Thanks! I misspelled the company name in the FB comment. It’s Alfatradiol by Ell-Cranell.

[LukeMV]

Mind sharing the dosages and specific drugs you’re taking for what you listed? (For instance which SGLT2, PDE, dosages, etc)

[Jonas]

@desertshores

Rapamycin
Metformin
Acarbose
Lithium
Atorvastatin

How long have you been on Metformin and why?