Turmeric Linked to Liver Damage, Decrease in Rapamycin Bioavailability

[RapamycinCurious]

@Connor

Sorry if I am waking up a topic that people feel is closed, but I am wondering if taking the Longvida form of curcumin would have the same effect on rapamycin as has been reported for most forms of curcumin/turmeric.

The absolute dose of curcumin in Longvida is a small fraction of the doses typically given: that alone should reduce the risk. Plus, its higher systemic bioavailability is due to avoiding metabolism in the liver (and also the intestine), which I would think would mean a further reduction in hepatic exposure and therefore tox potential.

[Dr.Bart]

I just tried Theracurmin for past few days and took my rapamycin yesterday. It hit me hard. Lots of fatigue and trouble sleeping.
I am so confused reading this thread because from what I read - multiple studies, curcumins can inhibit cytochrome p450 and thus increase rapa level. Also increased tamoxifen, steroids, etc.
Unfortunately I don’t have the time to get my blood levels checked.

[CronosTempi]

I stopped curcumin/turmeric supplementation a couple of months before taking rapamycin, because I read that c/t affects rapa, but there are conflicting claims about in what way and in what direction. I therefore stopped c/t, because there’s too much confusion here. Rapa is the intervention I’m interested in, so anything that strongly affects it, but nobody can clearly explain in what way, is not worth the risk of unfavorable interference. YMMV.

[John_Hemming]

I take both Berberine and Curcumin which have effects in both directions. Hence I take Rapamycin a few hours before them.