Urolithin A experiment - does it do anything?

[John_Hemming]

I am not sure the major supplement companies want to take on the risk at this stage. If you are a new company only selling UA on a drop shipping basis then setup costs are quite low. If Nestle take legal action and this causes the business to cease then profits will have been taken out in the mean time and there is no big loss.

If you are a major supplement company then there is something to lose.

[mondagai]

Embrace risk

I’ve had it for months but have been hesitant to actually try it. It did bring my Temu order price up enough to get free shipping, and it was either this or a butt plug

[Tom_C]

A good choice! Butt plugs are riskier

[John_Hemming]

Oddly enough I have not tried a butt plug. What does that do for gene expression?

[CronosTempi]

Does more for jeans expression, and especially facial expression.

[John_Hemming]

My Dexcom session has ended. I am not persuaded that UA had much of an effect here. I am happy to post the glucose charts if anyone wants them. These are the averages by day

2025-01-28 Average			6.534285714
2025-01-29 Average			5.883272727
2025-01-30 Average			5.958680556
2025-01-31 Average			5.575694444
2025-02-01 Average			5.634615385
2025-02-02 Average			5.346689895
2025-02-03 Average			5.326071429
2025-02-04 Average			5.596350365
2025-02-05 Average			5.332269504
2025-02-06 Average			5.349090909
2025-02-07 Average			5.235

Because my food and activity is not exactly the same every day I don’t think the movements are that significant. I ate the UA on 31/1/25.

Whether the trend down is linked to the sensor error varying or is a real trend I am unsure.

[Olafurpall]

@John_Hemming

I think its IC50 for mTOR is in the micromolar range whilst rapamycin is in the nanomolar range, but on the other hand people eat grams of UA comparing to milligrams of rapamycin.

ChatGPT came up with similar results on the IC50s for UA (10-50 microMolar) and Rapamycin (0.1-1 nM). It was also vague about whether UA really inhibits mTOR. That actually only the lower figures gives a ratio of 10mcM to 0.1nM viz 100,000. Ie to have the same effect as 1mg of Rapamycin you would need to eat 100g of UA.

If that’s the IC50 then it’s almost certain you won’t get significant inhibition with urolithin A. Urilithin A is a polyphenol and you almost never reach micromolar concentrations in plasma from ingesting polyphenols even at high doses. This is because they are heavily metabolized in the intestines and liver so they have poor bioavailability.

[John_Hemming]

As it stands UA is not on my list of interesting molecules and i probably wont look at it again.