shc
#163
Vaccine for pancreatic cancer. Publication in Nature shows how the T-cells derived from vaccination lasts for a long duration meaning prolonged protection.
https://www.nature.com/articles/s41586-024-08508-4
Thread on Twitter/X: https://x.com/TheVinodLab/status/1892245578446184873
1 Like
AnUser
#164
I don’t take Rapamycin myself right now, but maybe this might be important? I’ll get it for other reasons anyway.
Study from last year in The Lancet:
We investigated the effectiveness of pneumococcal vaccination in preventing morbidity and mortality associated with pneumonia in patients with immune-mediated inflammatory diseases.
In the multivariable analysis, pneumococcal vaccination was negatively associated with hospitalisation due to pneumonia (adjusted odds ratio 0·70 [95% CI 0·60–0·81]), death due to pneumonia (0·60 [0·48–0·76]), and lower respiratory tract infection treated with antibiotics (0·76 [0·72–0·80]).
Pneumococcal vaccination is associated with protection against hospitalisation and death due to pneumonia in patients with immune-mediated inflammatory diseases
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00128-0/fulltext
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KiwiGuy
#165
I’m double triple vaxxed and happy to be a pin cushion… some of my best mates aren’t vaxxed - it’s entirely up to them!
I even offered to get a vax for one of my anti-vax mates (turn up, say I was him & take his jab) (so he wouldn’t have employment issues). He wanted to take a moral stand and wouldn’t let me (lost his job, but seems happier in his new one).
We’ve all survived Covid. Let’s see if we can work together and also survive CVD, Cancer, Diabetes, Neuro-degeneration etc…
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AnUser
#166
For some reason I thought the Shingles vaccine couldn’t be taken together with pneumococcal, but that’s incorrect. I wouldn’t anyway but worried about interactions and order of vaccination:
E.g. from AUSG:
Can the Shingrix vaccine be given at the same time as other vaccines?
Shingrix® can be given at the same time as most other vaccines, including influenza and pneumococcal. However, it is best to have it by itself if possible. This can reduce the reactions experienced from having multiple vaccines. Talk to your doctor or other vaccination provider for advice.
shc
#167
I have taken the shingles vaccine with another vaccines. And in general, vaccines can be taken with each other which is why they are combined (MMR, TDAP, HepA/B, etc.).
However if you have the luxury of being able to take them seperately, that may be a good idea, especially for the second dose of shingles which can elicit a pretty large immune response. Gulian Barr syndrome is a rare side effect of shingles vaccines (1-2 additional cases per million doses for Shingles). And it isn’t known if this can be reduced by number of vaccines taken at once or by lowering the dose — but maybe it could lower risk in the margin.
As for me, I took it with another vaccine because it was more convenient…
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adssx
#169
Paper: A natural experiment on the effect of herpes zoster vaccination on dementia 2025
Using these comparison groups in a regression discontinuity design, we show that receiving the zoster vaccine reduced the probability of a new dementia diagnosis over a follow-up period of 7 years by 3.5 percentage points (95% confidence interval (CI) = 0.6–7.1, P = 0.019), corresponding to a 20.0% (95% CI = 6.5–33.4) relative reduction. This protective effect was stronger among women than men.
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adssx
#170
I just got shingles 
32yo male. It’s pretty mild but I wish I had taken the jab (I tried to but I couldn’t in London…)
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shc
#171
Oh no! I believe there are antivirals that you’d want to look into – the sooner you take them the more they help…
Btw, the earlier shingles vaccine before shingrix - Zostovax was just a higher dose of the chickenpox vaccine,Varivax. Based on this, I did a full course of the chickenpox vaccine a couple years back hoping it’d prevent shingles. A year later though, I was able to get access to Shingrix in Canada and took that (age: 37), because I was about to move countries.
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adssx
#172
Yes I’ve just started aciclovir. Unfortunately rather late in the course of the disease. Indeed I asked ChatGPT and it said it was a fungal infection so I put anti fungal cream… until the (mild) stabbing pain arrived and I went to the doctor…
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?? Childhood vaccination against chickenpox standard in France in the early 90’s?
Epidemiology of chickenpox in France (1991-1995)
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That’s so rare at this age. My buddy was in his later 40s going thru a nasty divorce when I diagnosed him with Ramsay-Hunt syndrome. Bell’s palsy, hearing loss, vertigo, balance issues… did physical therapy, improved some but couple of year later still has neurologic damage (persistent 80% unilateral hearing loss and mild facial paralysis). This virus is no joke.
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adssx
#175
No, chickenpox vaccination only started in 2004 in France. I got chickenpox, not the vax.
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adssx
#176
I thought as well but it’s actually not that rare: Shingles Facts and Stats | Shingles (Herpes Zoster) | CDC
The rate in people aged 55–65 (6/1000) is “only” 4 times the rate in people aged 25–35 (1.5/1000). I thought it would be 10x or even 100x:
It’s actually increasing in young people (30–39yo) while it’s decreasing in people aged 70+ and plateauing in other groups. The rate in people aged 30–39 in 2019 was almost identical to the rate in people aged 50–59 in 1998!
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Beth
#177
JFC, you can’t catch a break!!!
I’m sorry to hear this. Sending hugs!!!
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Neo
#178
Good write up by Dr Topol
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Neo
#179
hope you feel better soon @adssx !
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AnUser
#180
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shc
#181
Well, old smallpox vaccines were initially used to help with monkeypox (mpox) when it started surging
But Jynneos is a new vaccine dedicated to mpox (and also works against smallpox). I see little harm in taking this and probably much easier to get this than some old smallpox vaccine.
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Its relatively inexpensive:
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Hmm, $300 for an old vaccine is not exactly what I would call cheap.
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