KarlT
#41
And that’s the problem, “you like it or you don’t “ is not scientific. If you don’t like the discussion, don’t discuss.
Goran
#42
I am sorry but I can not help myself, I just have to say that the few studies that Rhonda, Attia and Sinclair are referring to that shows a blunt in muscle mass and some small negative effects on VO2 max when taking metformin during periods of exercise. They are all repeating each other.There are more studies that shows that Metformin is protective of muscle. Strength of muscle does not change, just a bit of mass. A part from the few negatives regarding this issue with metformin, there are so many positives on many other aspects of health.
If you are not bothered to read the papers published then this discussion if useless.
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This is a good paper. It makes me wonder if elevated glucose is a sign of too much rapamycin (inhibited mTORC 2).
For elevated glucose (not increased by rapamycin ), I fire all the barrels: low dose metformin 4 days a week (I take because I couldn’t get acarbose but I’m okay with it now), berberine, slgt2, zero processed sugar and starch, food order, 1 24 fast per week, daily no lunch and early dinner, daily exercise, low AGEs in diet. Working on: stress and sleep mgmt.
Blood work at end of October to see effects.
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KarlT
#44
@Joseph_Lavelle
Have you done self experiments to see what glucose levels do as you add or subtract each of those many meds/supplements.
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KarlT
#45
@Goran I think you kinda comparing apples to oranges. Your quoted articles are mostly talking about muscle retention in non active older people which may be true and makes Metformin useful in those cases.
What Dr Patrick said was that Metformin does not have an additive impact on top of exercise.
I would not dismiss the opinions of Attia as he has a team of researchers to look into all of this. I have no idea what Sinclair is saying as I don’t listen to him.
I do not have a CGM at the moment, so I am relying on “feel”. When I did have a CGM, food order (fat & protein before carbs), added sugar, and moderate exercise (walking) after eating a large meal were the big factors. Harder exercise actually increased blood glucose right before and during exercise, but the effect was temporary. As far as metformin plus berberine, I lower my berberine (1x vs 2x 500mg) on days when I take metformin (500mg slow release). I have used feelings of low blood sugar to work out the dosing schedule that works for me. SGLT2 does not have much impact on my glucose (or anything I can tell), but I’m sticking with it for now out of inertia. The fasting acts as a reset; i just feel better when I have some fasting in the schedule (i fast the day after rapa dosing). AGEs avoidance (no fried/grilled foods) is something I’ve coincidentally done for other reasons for a while so I cannot speak to effects.
There is a very interesting and informative new podcast: How To Reduce Your Pace Of Aging: Understanding Longevity and Biological Aging with Ryan SmithThe Joe Cohen Show
According to the Ryan Smith from Tru Diagnostics, Metformin is one of the best medications/supplements helping with reducing biological age.
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Jonas
#48
Just listened to his video
Have not had time to look into the details but I thought someone may have followed up with this debate?
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