In the end, I decided to try Telmisartan first before Tadalafil (I couldn’t find a reasonable price from a reputable supplier in India, and I don’t want to deal with US prescriptions).
I’ll start at a dose of 20 mg of Telmisartan daily and then move up to 40 mg. My BP is in the 106-128 SBP range, so to be optimal, it can be a bit lower, and I do like the extra insulin sensitivity and mitochondrial boost it provides. Also, the price was quite reasonable at:
Telmisartan 40mg Tablet= 1.5 USD for 10 tablets (Sun Pharma)
Is there any reason I should not add this med to my longevity stack?
elena
#43
Here’s a shortlist of medications often associated with promoting longevity:
- Rapamycin: A drug with anti-aging properties, showing promise in extending lifespan in various studies, though still under research.
- Metformin: Commonly used to treat type 2 diabetes, it shows promise in extending lifespan and delaying age-related diseases.
- Statins: Prescribed to lower cholesterol levels and reduce the risk of heart disease, potentially contributing to longevity.
- ACE Inhibitors: Medications used to treat high blood pressure and heart failure, with potential benefits for longevity and cardiovascular health.
- Resveratrol: Found in red wine and grapes, it’s believed to have anti-aging effects and promote longevity.
Always consult with a healthcare professional before starting any new medication or supplement regimen, especially for longevity purposes.
I am not myself persuaded that Metformin should be on that list, nor Resveratrol. I think there is some evidence that they should not be.
Statins maybe. I have no idea about ACE inhibitors. (I was prescribed one about 20 years ago and stopped taking it after a few months).
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elena
#45
Statins have shown promising results in reducing cardiovascular risk, which is linked to longevity, but their overall impact on lifespan is still debated. ACE inhibitors, like any medication, have potential benefits and risks that should be carefully considered based on individual health circumstances.
I understand your concern regarding the inclusion of Metformin and Resveratrol on the list. It’s essential to acknowledge that opinions on these medications’ efficacy for longevity vary among people.
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@Elena did you use ChatGPT (or other Ai bot) for this? Resveratrol has been disproven many times by scientists, the only person really pushing it still is David Sinclair. If you are still positive on resveratrol, you may want to view this video: https://youtu.be/jOE7VsjuFP8?si=_E11cGX0WBED8K_q&t=450
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I would argue that Metformin should definitely be on that list – for pre-diabetic and diabetic individuals. Getting your blood sugar into the ideal range should do wonders for longevity.
Unfortunately, I would argue that most older folk in the Western world are more likely to be pre-diabetic or diabetic than not. Therefore, it is a longevity drug for most.
However, empagliflozin would be even better.
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I will agree only for pre-diabetic and diabetic individuals. Hence I do not think it is a general pro longevity drug even if many people may benefit from it.
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Beth
#49
I’m sure this is of no help!, but there is also something about telmisartan that can be supportive to kidneys. Perhaps this is only in those with existing disease.
Why do I know this? My cat has just been put on this for his kidney disease, and fwiw, my cat has better doctors than I do.
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FWIW: I love metformin, but can only take 500mg/day because it causes a stomach gripe, in me, at higher levels. I will be switching to a timed-release version.
I agree with others that the resveratrol hype turned out to be untrue.
Metformin has been on several lists of compounds synergistic with rapamycin in prolonging life.
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Ulf
#51
Despie me posting that warning on the risks of combining supplements, I have continued missing out on this. The allure of the great promise of each supp has been too great. I try to narrow my list but am there at around 15. Hope to work through each one for combination and side effects. Writing this to strengthen my resolve.
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I know, the urge to “do something” about the problem of aging is powerful. But it is also good to keep in mind that the ultimate irony would be paying and doing things, and spending time on activities and purchases that might actually reduce our longevity.
It doesn’t take too much research to reveal that 20 years ago lots of people were dosing high levels of vitamin E and beta-carotene for health purposes, only to find out it probably increased risks of cancer, etc. Vitamin E and Beta-Carotene Supplements Not Recommended - Tufts Health & Nutrition Letter
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It is extremely frustrating when someone posts about their stack of medications and supplements and asks for advice on taking even more when the most fundamental approaches to good health are being ignored. If you are admittedly overweight and don’t exercise in a way that increases your aerobic capacity and muscle strength, then you’re just swimming against the tide with all those meds. Spend any money you were going to devote to new medicines and find a personal trainer and a nutritionist and start there. The one med addition that you might want to consider is a semaglutide analog such as ozempic that will help you lose weight and has now been shown to decrease cardiac mortality and morbidity.
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Those are all very valid points. However, we all have our own weaknesses due to our choices and circumstances. Some of us drink alcohol, some eat unhealthy foods, others don’t get enough sleep, and yet others are more sedentary. I have the latter problem as I don’t have a lot of time to hit the gym and motivation is also an issue. I do get in at least 6,000 steps a day and try to use the stairs as much as possible. I also do soleus pushups daily and eat mostly a healthy diet, but I do have a hunger issue and eat a bit too much. Too much of a good thing is still bad. (Ex. My breakfast is a bowl of steel-cut oatmeal and black coffee. My lunch is a homemade chopped vegetable salad with protein. Dinner is usually steamed fish, stir-fried vegetables and a protein. Snacks are almonds or walnuts.) I probably eat too many almonds.
I have maintained my body weight for many years, but I would like to shed some pounds. My body seems to increase my hunger levels whenever I start to lose weight. I do hope that when I retire at 60, I can really start to lose weight because I really enjoy hiking and cycling, and I expect to do either of those two activities instead of going to work in retirement. However, until then, when I get home, it’s hard to do anything except take a shower, eat dinner, spend some time with my family, and crash.
For now, the meds help me to remain healthy (4.9 HBA1C, 65 LDL, etc…) until I can change my lifestyle to be even healthier naturally. I would rather be healthy with meds than unhealthy without meds.
A semaglutide analog is looking better and better each day though. It’s probably what I need most to be honest. I’m just afraid of losing muscle mass.
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Neo
#55
When I travel or during unusually busy weeks when I have to cut down on strength training sessions I use the Katalyst Suit that Bob Nelson, Peter Diamandis have praised.
It takes a bit of time to set up (but that is a time where you can chill or where you could be on a call or listen to a podcast or something).
And then you get like a 2 hour workout in 20 min (I def feel the effects and it seems likes others here on the forum and on Reddit see real results too).
Even if you just did the 20 min session once a week you might see some meaningful progress
(It’s not cheap up front, but a gym would also cost each month and in many cases more over time).
It’s FDA approved
And one an award by Time for 2023:
They describe the science of EMS and their latest gen version of it here
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Neo
#56
Btw, no affiliation but it seems like they have a 25% off offer right now.
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I hear you, it is tough to live life perfectly. Good luck in your quest!
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I have been thinking of getting a Katalyst. For now I have just bought a weighted vest which goes from 0-30Kg. I am thinking of using this on my walks to and from my son’s school.
The Katalyst website seems to be not working properly at the moment.
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@DeStrider you are smart to keep the biomarkers healthy while you search for lifestyle improvements. You might find some hunger management tricks in this talk with Dr Livingston.
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Neo
#60
I’ve been using. Go-ruck weighted backpack for walks and it def turns them into much more of a workout.
Been thinking of a weighted vest to just wear round the house / office - which one did you get?
Having said above, EMS is really in a different category than weighted walks, so the effects would be more complementary and synergistic than substitutes.
What is the issues with the webpage? The one on science above works for me when I re-click. Here is also their landing page: https://www.katalyst.com/
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I accept that EMS is a different league.
This is what I bought:
https://www.amazon.co.uk/dp/B0C94S19MB?ref=ppx_yo2ov_dt_b_product_details&th=1
As I see it it has the potential of adding benefit to routines I do normally.
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