#430

Great idea, and thank you! I’ll do the same if there is anything to share.

I’ve always struggled with lack of energy and I assume it’s due to my lifelong thyroid issues, but I will say the week since my first 1mg dose has been good energy-wise. I wouldn’t think 1mg once would do ANYTHING, and sometimes I do just feel more energetic than others, but thought that was worth sharing just incase it’s related, which I doubt!

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#431

On the short-term impact on immune function:

I’m sorry if it’s a newbie question and this is covered elsewhere, but is there good data on whether there is a transient drop in the immune function (e.g., on the day rapamycin is taken, assuming the standard ~6 mg once a week cycle). If so, do we know how long this drop lasts?

I’ve seen that it might have long-term immune modulating effects, but I’m curious if one should be more careful on the day they take rapamycin and maybe for a few more days afterward.

Thanks!

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#433

One good way to determine a correct dosage would be to measure the mTOR inhibition in human adipose tissue (fat cells). If mTOR was being inhibited in adipose tissue, I would assume that the dose would be effective. Anyone care to be the guinea pig for this?

Maybe Bryan Johnson could help us out here?

#434

This is a good question, but I’ve not seen any good data on it.

It would depend on the actions that drive immune suppression; is it mTORC1 inhibition, or mTORC2 inhibition that drives the immune suppression. I’ve not studied up on this, but perhaps other people here have.

Here are some papers that seem likely to be covering this issue. I don’t have time right now - but this is an interesting issue and area.

Immunoregulatory Functions of mTOR Inhibition

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847476/

New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061789/

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#435

Dear Agetron,

Why do you think that the high dosing of Rapamycin caused the clogged eye duct?

I experienced Blefaritis (clogged tear duct) myself some weeks ago and this coincidentally occurred after I increased my dose (6mg weekly with GF juice on the first 3 days).

Never thought that Rapa could be a cause.

Doctor told me Blefaritis is chronic.

I increased my dose even further about 4 weeks after the symptoms started and the symptoms (inflammation, dry eye, pain) went away.

Not experienced more symptoms although I feel “something is not right”, but it may be the regular pollen allergies.

Is there any literature that states that Rapa can cause these type of problems with the eyes / eye lids (Blefaritis) & clogged eye duct, or do you suspect Rapa is the cause?

Thank you very much for sharing your experiences.

Sincerely

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#436

Yes, I had eye duct blockage, when using high doses of rapamycin 10 mg plus GFJ…52 ng/mL.

This occureed on 3 occasions and no amount of prescription eye drops. Antibiotic ointment or antibiotics seem to have any effect on it. Once it began, it was something you’d have to live with for about a week and a 1/2. It looked a lot like pink eye.

Since redixing my dosage of rapamycin, I have not have any issues with eye ducts for over a year. It was awful. Dr. Blogsklonny said that more rapamycin was better, but I think he was wrong on that. What I discovered was that I was overdosinge, ankle swelling and eye ducts isdues was some silent pathology.

I’d also read somewhere that overdosing could cause duct blockage, but I forget where that was. I was truly baffled the first time the second time it was crazy and the third time it happened. I knew there was something to do with the rapamycin.

Again, I never had this issue in my entire life and to have it 3 times within a year. During high. Rapamycin Dosing confirms in my mind. That it was the problem, especially since it has never occurred again on average doses for over a year and a half.

Hope this helps.

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#437

Thank you very much for your feedback. This is really helpful!

Best regards

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#438

I appreciate that the majority of physicians work in a “system” with rules, procedures, and hard guidelines. I’m over 65 and not very wealthy so SS adds an additional layer of regulation. I’m having difficulty finding a primary care physician. Mention astaxanthin, or methylene blue, or even something as basic as D3 supplementation and you’re on the “crazy list” and with SS that mean you’re on minimal care. If you end up in the hospital, its not the primary’s problem. And I appreciate that if a patient is taking weird substances, there is no way to know how anything, even something as simple as an antibiotic would react, so yeah they put you on the crazy ignore list. I might do the same if I was in their shoes.

But that leaves me “treating myself”. Sometimes it turns out well. I started rapa and had read it helped with periodontal issues, i.e. gingivitis. I’ve had problems with it over the years and hoped it might be a “bonus”.

While researching rapa/periodontal issues I read that azithromycin can “cure” pero also. So I did rapa and started azithromycin, a heavy dose 2x500mg a day for 4 days. It worked, my pero seems to be gone, my gums are great. As a side benefit, I’d had a pain in my left mid quadrant for decades. Doctors just blew it off since I wasn’t doubled over in pain.

The azithromycin (possibly with help of the rapa) cleared up the mysterious pain I was having in my gut. I think it must have been pylori, but this is a serendipitous result. Most of the time, flying solo, is a scary, dangerous trip, and I’ve screwed up a few times over the years.

I could keep bouncing around till I find a doc that was flexible, but I’ve got access to most classes of drugs and can treat myself fairly well. Its weird I spend $30K a year on health insurance (private, family, SSb&d) and the actual benefit to me is zip, maybe its the cost of being free and healthy, idk.

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#440

Periodontal gum disease?

I completely understand your frustration with healthcare being really sick care, not working very hard to help optimize somebody already healthy. Yet we are paying for this. I eventually got concierge and am happy with this, though it’s another $2000 but the doc is very good and flexible.

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#441

For that much money, I should hope they are good. :smile: For most people, that is just unaffordable.

MHO, the technology isn’t really developed enough to make that worth doing unless $2k/month is peanuts in your budget.

#442

It’s actually more like $1600/year. He does a complete physical and 4 partials for that. I go for it because I like him and hate shopping for a doc, I’ve been lucky a couple times but unlucky several too.

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#443

Just don’t tell your primary care doctor what you do on your own, and more times than not throw in garbage meds they give you. You get much better info out of websites and youtube than from them. Use them just to order lab results and explain them to you.

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#444

Don’t give up. It took me years to find my first integrative practice primary care physician. When he retired 12 years later, it took 3 more years and a couple of unsatisfactory choices before I found another one.

If your requests are reasonable, and your conversations show that you are fairly well informed, the right doctor will work with you. I’m not sure how many will be approving of methylene blue, for example, but you should be able to find someone who will be accepting of rapamycin and willing to prescribe meds that are commonly prescribed off label for preventive use even when insurance companies dont agree.

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#445

Telehealth makes this much easier. Here are a quick list of medical doctors I’ve interviewed recently who offer telehealth services.

Dr Vyvyane Loh (internal medicine)
Dr Michael Twyman (cardiologist plus)
Dr Scott Sherr (internal medicine plus, including MB)
Dr Doug Lucas (bones and more)
Dr Rick Cohen (testosterone and more)

And others who frequent this forum:
Dr Grant (longevity medicine)
Who else?

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#447

Just to piggy back on this…. I have had a couple of brief chats with @DrFraser, and if someone is looking for a doc, I would not hesitate contacting him to see if it’s a match. I’ve been impressed with his knowledge base but also his guidance by science and a long time in practice.

I have a concierge doc so adding other people doesn’t make financial sense for me, but if I didn’t, I would definitely reach out to him.

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#448

Beth, I just saw this but figured I’d reply. I’m female, 54y/o-post menopausal for 7 years and 5’1/98.5 pounds. I’ve been on rapa since early Jan 2023 and have settled on a 3mg dose. Ideally I’d prefer to take 3.5mg but my current stock is 1mg pills. 4mg seems a bit too strong for me and even 1mg with standardized grapefruit pills feel like too much so I just use 3mg without anything else.

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#449

Would it possible to start a new poll on dosing? I’m curious how/whether things have changed as forum members try to optimize their dosing pattern
thanks

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#450

I think you’re right. Most of us on this rapamycin journey have to figure out what our best dose is.

From going too low… to going too high… to finding that sweet spot where things are just right.

As a 4 year early adopter. I finally centered on it, and hopefully blood tests and biological tests will prove me right. I found my sweet spot to be 4 mg, one week, 6 mg, the next week.

I tried very high for as long as seven months - and found that was actually biologically a bad choice. Now, having settled down to a lower amount… more like my original, those of six meg, once a week for the first year and a half… things were best.

Now all seems to be going as good as it can at 66.5 years… muscle, strength, mental ability… all good and continues to increase.

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#451

I’m trying 5mg rapacan with gfj every 14 days for 3 months. In an effort to try one blast at relatively high dose to increase chance of blood-brain crossing. Theory being that even one period could have lasting benefits.

Half way through and no sides. No noticeable benefits either…

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#452

I’m only taking it once in a while and then I use doses between 20 and 30mg, taken with olive oil on an empty stomach.

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