Looking at what I think was the paper
https://www.biorxiv.org/content/10.1101/2025.08.15.670559v1.full
In the supplementary documents table S5 seems to indicate that there were 5 placebo subjects and 4 rapamycin subjects which makes getting statistically reliable results hard.
It is also not clear whether their 1mg of rapamycin was compounded or not as they have a placebo.
In “methods” they don’t say how many subjects there were.
A probably with WBC is that it can vary for a number of reasons and actually in S5b they seem to mainly go up for placebo and rapamycin.
They do say “While participant numbers in the rapamycin in vivo study are low, the changes in DNA damage and senescence markers is significant.”
I am not persuaded by this paper.
That is not to say it is wrong, however.
Reading it a bit more the rapamycin levels are interesting in the three subjects who took it.
Sadly they don’t give the values but they are approximately 1.5, 2.75 and 5.5 ng/ml.
That is an interesting range.
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LaraPo
#534
1.5 and 2.75 are unrealistic for 1mg/day for 8 weeks.
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On blowing up the image it is nanoMolar sorry.
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Looking up the conversion 1nM is 0.914 ng/ml so you can sort of treat the figures as the same.
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