#41

Before mTOR modulation changes as we get older, how is mTOR modulated when it is optimal? - This may serve as a template for regulation with Rapamycin.

When does mTOR modulation go from optimal to suboptimal in the aging process?

Thank you for asking and have fun! My father grew up in Novato :slight_smile:

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#42

Have there been significant advances in discrimination of senescent vs non-senescent cells or other improved procedures for measuring effect of senolytics?

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#43

Folks - since I’ll be at the Longevity Summit this coming Tuesday and Wednesday I’ll be asking researchers a lot of questions. If you have specific questions that might help us translate the research into actionable programs, please post your questions and I’ll try to get answers.

Here are the researchers who are presenting at the Longevity Summit:

Schedule below is in Pacific Time.

  • Tuesday12/06

    • 8:00am - 8:40am

Breakfast & Networking Begins

  • 8:45am - 8:50am

Opening Remarks- Dr. Christin Glorioso- Co-founder & CEO, NeuroAge Therapeutics, Longevity SF.

  • 8:50am - 9:20am

Opening Keynote- Eric Verdin

  • 9:25am - 9:45am

Morgan Levine

  • 9:50am - 10:10am

Dr. Antoine Roux- Principal Scientist, Calico Life Sciences. “A Cell Atlas to Decipher Cell-type Aging”

  • 10:15am - 10:35am

Sergio Ruiz

  • 10:40am - 10:55am

Coffee break

  • 10:55am - 11:15am

Dr. Hanadie Yousef - Co-founder & CEO, Juvena Therapeutics. “Harnessing the Regenerative Secretome of Human Pluripotent Stem Cells to Rejuvenate Tissues”

  • 11:20am - 11:40am

Jennifer Garrison

  • 11:45am - 12:05pm

Dr. David Weinkove- CSO, Assoc. Professor, Chair, Magnitude Bio, Durham U., BSRA & Dr. Marc Lucanic- CTO, GeroState Alpha. “Using C. elegans to find new drugs to slow aging”

  • 12:05pm - 1:15pm

Lunch & Networking Break

  • 1:15pm - 1:45pm

Opening Keynote- Dr. Spring Behrouz & Andy Lee- Founders, Vincere Biosciences. “The Path to Developing Selective Mitophagy Enhancing Small Molecules”

  • 1:50pm - 2:10pm

Dr. Priyanka Joshi - Research Fellow, Co-founder, UC Berkeley, NeuroAge Therapeutics. “Targeting Aging to Treat Alzheimer’s Disease”

  • 2:15pm - 2:35pm

Dr. Salah Mahmoudi- Assoc. Director, Alkahest. “Molecularizing the Science of Plasma to Therapeutically Target Diseases of Aging”

  • 2:40pm - 3:00pm

Dr. Marco Quarta- Co-Founder and CEO, Rubedo Life Sciences. “Next Gen Senolytics for Selective Targeting Senescent Cell States to Treat Chronic Diseases of Aging”

  • 3:05pm - 3:20pm

Coffee break

  • 3:20pm - 3:40pm

Nathan Cheng - Director, GP, Founder, ODLB, Healthspan Capital, Longevity List. “The State of Longevity (2022)”

  • 3:45pm - 4:05pm

Dr. Todd Haim- Director of NIA’s Office of Strategic Extramural Programs. “NIA’s Efforts to Foster Diversity in Aging Research and Entrepreneurship”

  • 4:10pm - 4:30pm

Dr. James Peyer- CEO and Co-founder, Cambrian Bio. “Moving Beyond Generics and Supplements in Developing Healthspan-extending Medicines”

  • 4:35pm - 5:05pm

Investors Panel- Maryanna Saenko, Ole Mensching, Max Unfried

  • 5:05pm - 7:00pm

Wine and Hor D’oeuvres- Buck Institute

  • Wednesday12/07

    • 8:00am - 8:40am

Breakfast & Networking Begins

  • 8:45am - 8:50am

Opening Remarks- Dr. Christin Glorioso- Co-founder & CEO, NeuroAge Therapeutics, Longevity SF.

  • 8:50am - 9:20am

Opening Keynote- Dr. Matt Kaeberlein- Professor, University of Washington, CSO, Optispan Geroscience. “The Dog Aging Project: A Template for Companion Animals in Geroscience”.

  • 9:25am - 9:45am

Celine Halioua

  • 9:50am - 10:10am

Dr. Ashley Zehnder- Co-founder & CEO, Fauna Bio. “Hibernation: A Survival Strategy Giving us Clues to Human Longevity”

  • 10:15am - 10:35am

Dr. Marina Martinić Kavur- Head of R&D, GlycanAge. “Turning Back the Glycan Clock”

  • 10:40am - 10:55am

Coffee break

  • 10:55am - 11:15am

Dr. Tim Peterson - Professor, WashU. “The Chemistry that Unites Infectious Disease and Aging.”

  • 11:20am - 11:40am

Dr. Oki O’Connor- Co-Founder and CEO of Scientific Affairs, Cyclarity Therapeutics. “A New Class of Drugs for Removing Toxic Biomolecules that Accumulate with Age”

  • 11:45am - 12:15pm

Media Panel- Stephanie Dainow, Chris Patil, Allison Duettmann

  • 12:15pm - 1:15pm

Lunch & Networking Break

  • 1:15pm - 1:45pm

Opening Keynote- Dr. Stacie Walton & Yvonne Dotson, RN. “Endangered . . Black Women Longevity Disparities”

  • 1:50pm - 2:10pm

Joanna Bensz

  • 2:15pm - 2:35pm

Judy Okten-CEO and Co-Founder, Burgeon Labs. “The Longevity Ecosystem: Unlocking the Digital Patient Journey for Better Outcomes”

  • 2:40pm - 3:00pm

Dr. Charles Brenner- Professor & Chair, City of Hope. “Use Cases for Nicotinamide Riboside in Maintenance of Resiliency in Human Aging”

  • 3:05pm - 3:20pm

Coffee break

  • 3:20pm - 3:40pm

Eric Morgen

  • 3:45pm - 4:05pm

Dr. David Furman- Director, Assoc. Professor, Stanford 1,000 Immunomes, Buck Institute. “Longevity and Space: The Final Frontier”

  • 4:10pm - 4:30pm

Dr. Adam Freund- Founder & CEO, Arda Therapeutics. " Eliminating pathogenic cells that drive chronic diseases and aging"

  • 4:35pm - 5:05pm

Founders Panel: Challenges and Opportunities in Building a Longevity Company- Robin Mansukhani, Dr. Maddalena Adorno, Dr. Francisco LePort, Dr. Joe Rodgers

  • 5:30pm - 8:30pm

Wine and Cheese Party- Mantra Wines